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BioLiP
Download all results in tab-seperated text for 94 receptor-ligand interactions, whose format is explained at readme.txt.
  • Hover over PDB to view the title of the structure. Click PDB to view the structure at the RCSB PDB database. Resolution -1.00 means the resolution is unavailable, e.g., for NMR structures.
  • Click Site # to view the binding site structure. Hover over Site # to view the binding residues.
  • Hover over Ligand to view the full ligand name. Click Ligand to view the 2D diagram and other detail information of the ligand.
  • Hover over EC number to view the full name of enzymatic activity.
  • Hover over GO terms to view all GO terms.
  • Hover over UniProt to view the protein name.

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    # PDB
    (Resolution Å)     		Site # Ligand EC number GO terms UniProt PubMed Binding
    affinity
    1 1azm:A (2.0) BS02 AZM 4.2.1.1
    4.2.1.69    		 GO:0004064 ... P00915 7932756 PDBbind: -logKd/Ki=6.10, Ki=0.8uM
    BindingDB: Ki=250nM, Kd=1400nM, IC50=5.8nM
    2 1dmy:A (2.45) BS02 AZM 4.2.1.1 GO:0004089 ... P23589 7479916 BindingDB: Ki=60nM
    3 1dmy:B (2.45) BS02 AZM 4.2.1.1 GO:0004089 ... P23589 7479916 BindingDB: Ki=60nM
    4 1jd0:A (1.5) BS02 AZM 4.2.1.1 GO:0004089 ... O43570 11493685 PDBbind: -logKd/Ki=8.24, Ki=5.7nM
    BindingDB: Ki=5.7nM, Kd=130nM, IC50=60nM
    5 1jd0:B (1.5) BS02 AZM 4.2.1.1 GO:0004089 ... O43570 11493685 BindingDB: Ki=5.7nM, Kd=130nM, IC50=60nM
    6 1rj6:A (2.9) BS02 AZM 4.2.1.1 GO:0004089 ... Q9WVT6 14660577
    7 1rj6:B (2.9) BS02 AZM 4.2.1.1 GO:0004089 ... Q9WVT6 14660577
    8 1yda:A (2.1) BS02 AZM 4.2.1.1
    4.2.1.69    		 GO:0002009 ... P00918 7696263 MOAD: Kd=280nM
    PDBbind: -logKd/Ki=6.55, Kd=280nM
    BindingDB: Ki=12nM, Kd=17nM, IC50=10nM
    9 1ydb:A (1.9) BS02 AZM 4.2.1.1
    4.2.1.69    		 GO:0002009 ... P00918 7696263 MOAD: Kd=5.8nM
    PDBbind: -logKd/Ki=8.24, Kd=5.8nM
    BindingDB: Ki=12nM, Kd=17nM, IC50=10nM
    10 1ydd:A (2.1) BS02 AZM 4.2.1.1
    4.2.1.69    		 GO:0002009 ... P00918 7696263 MOAD: Kd=86nM
    PDBbind: -logKd/Ki=7.07, Kd=86nM
    BindingDB: Ki=12nM, Kd=17nM, IC50=10nM
    11 1zsb:A (2.0) BS02 AZM 4.2.1.1
    4.2.1.69    		 GO:0002009 ... P00918 8639494 MOAD: Kd=250mM
    PDBbind: -logKd/Ki=0.60, Kd=250mM
    BindingDB: Ki=12nM, Kd=17nM, IC50=10nM
    12 2h4n:A (1.9) BS03 AZM 4.2.1.1
    4.2.1.69    		 GO:0002009 ... P00918 9398308 MOAD: Kd=0.002nM
    PDBbind: -logKd/Ki=8.70, Kd=2nM
    BindingDB: Ki=12nM, Kd=17nM, IC50=10nM
    13 2uy4:A (1.75) BS01 AZM 3.2.1.14 GO:0004553 ... P29029 17524989 MOAD: Ki=21uM
    PDBbind: -logKd/Ki=4.68, Ki=21uM
    BindingDB: Ki=21000nM
    14 2xtk:A (2.0) BS01 AZM 3.2.1.14 GO:0004553 ... B0Y2Y2 21044846 MOAD: ic50=164uM
    PDBbind: -logKd/Ki=3.79, IC50=164uM
    15 2xtk:B (2.0) BS01 AZM 3.2.1.14 GO:0004553 ... B0Y2Y2 21044846 MOAD: ic50=164uM
    16 3czv:A (2.0) BS02 AZM 4.2.1.1 GO:0004089 ... Q8N1Q1 18618712 MOAD: Ki=16nM
    PDBbind: -logKd/Ki=7.80, Ki=16nM
    BindingDB: Ki=17nM, Kd=50nM
    17 3czv:B (2.0) BS02 AZM 4.2.1.1 GO:0004089 ... Q8N1Q1 18618712 MOAD: Ki=16nM
    BindingDB: Ki=17nM, Kd=50nM
    18 3dc3:A (1.7) BS02 AZM 4.2.1.1
    4.2.1.69    		 GO:0002009 ... P00918 19170619 MOAD: Ki=4.9nM
    PDBbind: -logKd/Ki=8.31, Ki=4.9nM
    BindingDB: Ki=12nM, Kd=17nM, IC50=10nM
    19 3hs4:A (1.1) BS03 AZM 4.2.1.1
    4.2.1.69    		 GO:0002009 ... P00918 19851004 MOAD: Ki=10nM
    PDBbind: -logKd/Ki=8.00, Ki=10nM
    BindingDB: Ki=12nM, Kd=17nM, IC50=10nM
    20 3hs4:A (1.1) BS04 AZM 4.2.1.1
    4.2.1.69    		 GO:0002009 ... P00918 19851004 MOAD: Ki=10nM
    PDBbind: -logKd/Ki=8.00, Ki=10nM
    BindingDB: Ki=12nM, Kd=17nM, IC50=10nM
    21 3hs4:A (1.1) BS05 AZM 4.2.1.1
    4.2.1.69    		 GO:0002009 ... P00918 19851004 MOAD: Ki=10nM
    PDBbind: -logKd/Ki=8.00, Ki=10nM
    BindingDB: Ki=12nM, Kd=17nM, IC50=10nM
    22 3iai:A (2.2) BS02 AZM 4.2.1.1 GO:0004089 ... Q16790 19805286 BindingDB: Ki=25nM, IC50=1520nM, Kd=20nM
    23 3iai:B (2.2) BS02 AZM 4.2.1.1 GO:0004089 ... Q16790 19805286 BindingDB: Ki=25nM, IC50=1520nM, Kd=20nM
    24 3iai:C (2.2) BS02 AZM 4.2.1.1 GO:0004089 ... Q16790 19805286 BindingDB: Ki=25nM, IC50=1520nM, Kd=20nM
    25 3iai:D (2.2) BS02 AZM 4.2.1.1 GO:0004089 ... Q16790 19805286 BindingDB: Ki=25nM, IC50=1520nM, Kd=20nM
    26 3ml5:A (2.05) BS02 AZM 4.2.1.1 GO:0004089 ... P43166 20688517 PDBbind: -logKd/Ki=8.52, Ki=3.0nM
    BindingDB: Ki=2.5nM, Kd=17nM, IC50=3440nM
    27 3ucj:A (1.85) BS02 AZM 4.2.1.1 GO:0004089 ... Q96554 22162771 MOAD: Ki=1uM
    PDBbind: -logKd/Ki=6.00, Ki=1uM
    28 3ucj:A (1.85) BS03 AZM 4.2.1.1 GO:0004089 ... Q96554 22162771 MOAD: Ki=1uM
    PDBbind: -logKd/Ki=6.00, Ki=1uM
    29 3ucj:B (1.85) BS01 AZM 4.2.1.1 GO:0004089 ... Q96554 22162771 MOAD: Ki=1uM
    PDBbind: -logKd/Ki=6.00, Ki=1uM
    30 3ucj:B (1.85) BS03 AZM 4.2.1.1 GO:0004089 ... Q96554 22162771 MOAD: Ki=1uM
    PDBbind: -logKd/Ki=6.00, Ki=1uM
    31 3v2j:A (1.699) BS02 AZM 4.2.1.1
    4.2.1.69    		 GO:0002009 ... P00918 N/A BindingDB: Ki=12nM, Kd=17nM, IC50=10nM
    32 3v2m:A (1.471) BS02 AZM 4.2.1.1
    4.2.1.69    		 GO:0002009 ... P00918 N/A BindingDB: Ki=12nM, Kd=17nM, IC50=10nM
    33 3w6h:A (2.964) BS03 AZM 4.2.1.1
    4.2.1.69    		 GO:0004064 ... P00915 N/A BindingDB: Ki=250nM, Kd=1400nM, IC50=5.8nM
    34 3w6h:B (2.964) BS04 AZM 4.2.1.1
    4.2.1.69    		 GO:0004064 ... P00915 N/A BindingDB: Ki=250nM, Kd=1400nM, IC50=5.8nM
    35 4g0c:A (2.0) BS02 AZM 4.2.1.1
    4.2.1.69    		 GO:0002009 ... P00918 22928733 PDBbind: -logKd/Ki=7.92, Ki=12nM
    BindingDB: Ki=12nM, Kd=17nM, IC50=10nM
    36 4g7a:A (1.8) BS02 AZM N/A GO:0004089 ... N/A 23695259 BindingDB: Ki=4.5nM
    37 4g7a:B (1.8) BS02 AZM N/A GO:0004089 ... N/A 23695259 BindingDB: Ki=4.5nM
    38 4k0s:A (1.802) BS02 AZM 4.2.1.1
    4.2.1.69    		 GO:0002009 ... P00918 N/A BindingDB: Ki=12nM, Kd=17nM, IC50=10nM
    39 4lu3:A (2.0) BS02 AZM 4.2.1.1 GO:0004089 ... Q9ULX7 24374484 BindingDB: Ki=41nM, Kd=11nM, IC50=224nM
    40 4uov:A (1.85) BS02 AZM 4.2.1.1 GO:0004089 ... E8T502 25286845
    41 4uov:B (1.85) BS02 AZM 4.2.1.1 GO:0004089 ... E8T502 25286845
    42 4uov:C (1.85) BS02 AZM 4.2.1.1 GO:0004089 ... E8T502 25286845
    43 4uov:D (1.85) BS02 AZM 4.2.1.1 GO:0004089 ... E8T502 25286845
    44 4uov:E (1.85) BS02 AZM 4.2.1.1 GO:0004089 ... E8T502 25286845
    45 4uov:F (1.85) BS02 AZM 4.2.1.1 GO:0004089 ... E8T502 25286845
    46 4x5s:A (1.95) BS02 AZM 4.2.1.1 GO:0004089 ... C1DTU5 25817590
    47 4x5s:B (1.95) BS02 AZM 4.2.1.1 GO:0004089 ... C1DTU5 25817590
    48 4xiw:A (2.6) BS02 AZM 4.2.1.1 GO:0004089 ... Q39588 25617045
    49 4xiw:B (2.6) BS02 AZM 4.2.1.1 GO:0004089 ... Q39588 25617045
    50 4xiw:C (2.6) BS02 AZM 4.2.1.1 GO:0004089 ... Q39588 25617045
    51 4xiw:D (2.6) BS02 AZM 4.2.1.1 GO:0004089 ... Q39588 25617045
    52 4xiw:E (2.6) BS02 AZM 4.2.1.1 GO:0004089 ... Q39588 25617045
    53 4xiw:F (2.6) BS02 AZM 4.2.1.1 GO:0004089 ... Q39588 25617045
    54 4xiw:G (2.6) BS02 AZM 4.2.1.1 GO:0004089 ... Q39588 25617045
    55 4xiw:H (2.6) BS02 AZM 4.2.1.1 GO:0004089 ... Q39588 25617045
    56 4ygf:A (2.0) BS02 AZM ? GO:0004089 ... A0A0M3KL20 26010545 MOAD: Ki=21nM
    PDBbind: -logKd/Ki=7.68, Ki=21nM
    57 4ygf:B (2.0) BS02 AZM ? GO:0004089 ... A0A0M3KL20 26010545 MOAD: Ki=21nM
    58 4ygf:C (2.0) BS02 AZM ? GO:0004089 ... A0A0M3KL20 26010545 MOAD: Ki=21nM
    59 4ygf:D (2.0) BS02 AZM ? GO:0004089 ... A0A0M3KL20 26010545 MOAD: Ki=21nM
    60 4ygf:E (2.0) BS02 AZM ? GO:0004089 ... A0A0M3KL20 26010545 MOAD: Ki=21nM
    61 4ygf:F (2.0) BS02 AZM ? GO:0004089 ... A0A0M3KL20 26010545 MOAD: Ki=21nM
    62 4ygf:G (2.0) BS02 AZM ? GO:0004089 ... A0A0M3KL20 26010545 MOAD: Ki=21nM
    63 4ygf:H (2.0) BS02 AZM ? GO:0004089 ... A0A0M3KL20 26010545 MOAD: Ki=21nM
    64 5jn8:A (1.85) BS01 AZM 4.2.1.1 GO:0004089 ... P22748 28975383 PDBbind: -logKd/Ki=7.30, Kd=50nM
    BindingDB: Ki=74nM, Kd=100nM, IC50=17.5nM
    65 5jn8:B (1.85) BS01 AZM 4.2.1.1 GO:0004089 ... P22748 28975383 BindingDB: Ki=74nM, Kd=100nM, IC50=17.5nM
    66 5jn8:C (1.85) BS01 AZM 4.2.1.1 GO:0004089 ... P22748 28975383 BindingDB: Ki=74nM, Kd=100nM, IC50=17.5nM
    67 5jn8:D (1.85) BS01 AZM 4.2.1.1 GO:0004089 ... P22748 28975383 BindingDB: Ki=74nM, Kd=100nM, IC50=17.5nM
    68 5nek:B (3.057) BS02 AZM 3.5.1.104 GO:0005886 ... Q81EJ6 29257674
    69 5nek:D (3.057) BS02 AZM 3.5.1.104 GO:0005886 ... Q81EJ6 29257674
    70 6im3:A (2.0) BS02 AZM 4.2.1.1 GO:0004089 ... C0QRB5 31250619
    71 6im3:B (2.0) BS02 AZM 4.2.1.1 GO:0004089 ... C0QRB5 31250619
    72 6im3:C (2.0) BS02 AZM 4.2.1.1 GO:0004089 ... C0QRB5 31250619
    73 6im3:D (2.0) BS02 AZM 4.2.1.1 GO:0004089 ... C0QRB5 31250619
    74 6im3:E (2.0) BS04 AZM 4.2.1.1 GO:0004089 ... C0QRB5 31250619
    75 6im3:F (2.0) BS04 AZM 4.2.1.1 GO:0004089 ... C0QRB5 31250619
    76 6mwj:A (2.05) BS02 AZM 4.6.1.12 GO:0008299 ... Q3JRA0 N/A
    77 6qeb:A (-1.00) BS02 AZM 4.2.1.1
    4.2.1.69    		 GO:0002009 ... P00918 30688395 BindingDB: Ki=12nM, Kd=17nM, IC50=10nM
    78 6yma:A (2.5) BS02 AZM 4.2.1.1
    4.2.1.69    		 GO:0002009 ... P00918 32737395 BindingDB: Ki=12nM, Kd=17nM, IC50=6.7nM
    79 7coj:A (2.0) BS02 AZM 4.2.1.1 GO:0004089 ... Q4WQ18 32975213
    80 7coj:A (2.0) BS03 AZM 4.2.1.1 GO:0004089 ... Q4WQ18 32975213
    81 7coj:B (2.0) BS01 AZM 4.2.1.1 GO:0004089 ... Q4WQ18 32975213
    82 7coj:B (2.0) BS03 AZM 4.2.1.1 GO:0004089 ... Q4WQ18 32975213
    83 7coj:C (2.0) BS02 AZM 4.2.1.1 GO:0004089 ... Q4WQ18 32975213
    84 7coj:C (2.0) BS03 AZM 4.2.1.1 GO:0004089 ... Q4WQ18 32975213
    85 7coj:D (2.0) BS01 AZM 4.2.1.1 GO:0004089 ... Q4WQ18 32975213
    86 7coj:D (2.0) BS03 AZM 4.2.1.1 GO:0004089 ... Q4WQ18 32975213
    87 8dpo:A (2.6) BS01 AZM 4.2.1.1 GO:0004089 ... Q50940 N/A
    88 8dpo:C (2.6) BS01 AZM 4.2.1.1 GO:0004089 ... Q50940 N/A
    89 8dpo:E (2.6) BS01 AZM 4.2.1.1 GO:0004089 ... Q50940 N/A
    90 8dpo:G (2.6) BS01 AZM 4.2.1.1 GO:0004089 ... Q50940 N/A
    91 8dyq:A (2.15) BS01 AZM 4.2.1.1 GO:0004089 ... Q50940 36655133
    92 8dyq:C (2.15) BS01 AZM 4.2.1.1 GO:0004089 ... Q50940 36655133
    93 8dyq:E (2.15) BS01 AZM 4.2.1.1 GO:0004089 ... Q50940 36655133
    94 8dyq:G (2.15) BS01 AZM 4.2.1.1 GO:0004089 ... Q50940 36655133
    Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).

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