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BioLiP
Download all results in tab-seperated text for 834 receptor-ligand interactions, whose format is explained at readme.txt.
  • Hover over PDB to view the title of the structure. Click PDB to view the structure at the RCSB PDB database. Resolution -1.00 means the resolution is unavailable, e.g., for NMR structures.
  • Click Site # to view the binding site structure. Hover over Site # to view the binding residues.
  • Hover over Ligand to view the full ligand name. Click Ligand to view the 2D diagram and other detail information of the ligand.
  • Hover over EC number to view the full name of enzymatic activity.
  • Hover over GO terms to view all GO terms.
  • Hover over UniProt to view the protein name.
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    # PDB
    (Resolution Å)
    Site # Ligand EC number GO terms UniProt PubMed Binding
    affinity
    1 1aib:A (2.8) BS02 AKG 2.6.1.1 GO:0003824 ... P00509 7819232
    2 1aib:B (2.8) BS02 AKG 2.6.1.1 GO:0003824 ... P00509 7819232
    3 1bl5:A (2.5) BS01 AKG 1.1.1.42 GO:0000287 ... P08200 9783749
    4 1cw4:A (2.1) BS03 AKG 1.1.1.42 GO:0000287 ... P08200 10623532
    5 1drt:A (2.1) BS03 AKG 1.14.11.21 GO:0005506 ... Q05581 10655615
    6 1dry:A (1.4) BS03 AKG 1.14.11.21 GO:0005506 ... Q05581 10655615
    7 1ds1:A (1.08) BS02 AKG 1.14.11.21 GO:0005506 ... Q05581 10655615
    8 1e5i:A (2.1) BS02 AKG 1.14.20.1 GO:0005506 ... P18548 11352583
    9 1ea0:A (3.0) BS03 AKG 1.4.1.13 GO:0004355 ... Q05755 11188694
    10 1ea0:B (3.0) BS03 AKG 1.4.1.13 GO:0004355 ... Q05755 11188694
    11 1gp4:A (2.1) BS01 AKG 1.14.20.4 GO:0007033 ... Q96323 11796114
    12 1gp5:A (2.2) BS01 AKG 1.14.20.4 GO:0007033 ... Q96323 11796114
    13 1gqw:A (3.0) BS02 AKG 1.14.11.17 GO:0000908 ... P37610 11955067
    14 1gqw:B (3.0) BS02 AKG 1.14.11.17 GO:0000908 ... P37610 11955067
    15 1gvg:A (1.54) BS02 AKG 1.14.11.21 GO:0005506 ... Q05581 12062399
    16 1gy9:A (2.5) BS03 AKG 1.14.11.17 GO:0000908 ... P37610 11955067
    17 1gy9:B (2.5) BS02 AKG 1.14.11.17 GO:0000908 ... P37610 11955067
    18 1h2l:A (2.25) BS03 AKG 1.14.11.30
    1.14.11.n4
    GO:0003714 ... Q9NWT6 12446723
    19 1h2n:A (2.84) BS02 AKG 1.14.11.30
    1.14.11.n4
    GO:0003714 ... Q9NWT6 12446723
    20 1hwy:A (3.2) BS01 AKG 1.4.1.3 GO:0004352 ... P00366 11254391
    21 1hwy:B (3.2) BS02 AKG 1.4.1.3 GO:0004352 ... P00366 11254391
    22 1hwy:C (3.2) BS01 AKG 1.4.1.3 GO:0004352 ... P00366 11254391
    23 1hwy:D (3.2) BS01 AKG 1.4.1.3 GO:0004352 ... P00366 11254391
    24 1hwy:E (3.2) BS02 AKG 1.4.1.3 GO:0004352 ... P00366 11254391
    25 1hwy:F (3.2) BS02 AKG 1.4.1.3 GO:0004352 ... P00366 11254391
    26 1ika:A (2.7) BS02 AKG 1.1.1.42 GO:0000287 ... P08200 8369301
    27 1llw:A (2.7) BS03 AKG 1.4.7.1 GO:0006537 ... P55038 11967268
    28 1mdx:A (1.96) BS02 AKG 2.6.1.87 GO:0000271 ... Q8ZNF3 12429098
    29 1mzf:A (2.4) BS02 AKG 1.14.11.30
    1.14.11.n4
    GO:0003714 ... Q9NWT6 12432100
    30 1nx4:A (2.4) BS02 AKG 1.14.20.3 GO:0005737 ... Q9XB59 12611886
    31 1nx4:B (2.4) BS02 AKG 1.14.20.3 GO:0005737 ... Q9XB59 12611886
    32 1nx4:C (2.4) BS02 AKG 1.14.20.3 GO:0005737 ... Q9XB59 12611886
    33 1nx8:A (2.3) BS02 AKG 1.14.20.3 GO:0005737 ... Q9XB59 12611886
    34 1nx8:B (2.3) BS02 AKG 1.14.20.3 GO:0005737 ... Q9XB59 12611886
    35 1nx8:C (2.3) BS02 AKG 1.14.20.3 GO:0005737 ... Q9XB59 12611886
    36 1ofd:A (2.0) BS03 AKG 1.4.7.1 GO:0006537 ... P55038 12818206
    37 1ofd:B (2.0) BS03 AKG 1.4.7.1 GO:0006537 ... P55038 12818206
    38 1ofe:A (2.45) BS03 AKG 1.4.7.1 GO:0006537 ... P55038 12818206
    39 1ofe:B (2.45) BS03 AKG 1.4.7.1 GO:0006537 ... P55038 12818206
    40 1oii:A (2.19) BS02 AKG 1.14.11.77 GO:0005737 ... Q9WWU5 15023059
    41 1oii:B (2.19) BS02 AKG 1.14.11.77 GO:0005737 ... Q9WWU5 15023059
    42 1oii:C (2.19) BS02 AKG 1.14.11.77 GO:0005737 ... Q9WWU5 15023059
    43 1oii:D (2.19) BS02 AKG 1.14.11.77 GO:0005737 ... Q9WWU5 15023059
    44 1oij:A (2.1) BS01 AKG 1.14.11.77 GO:0005737 ... Q9WWU5 15023059
    45 1oij:B (2.1) BS01 AKG 1.14.11.77 GO:0005737 ... Q9WWU5 15023059
    46 1oij:C (2.1) BS01 AKG 1.14.11.77 GO:0005737 ... Q9WWU5 15023059
    47 1oij:D (2.1) BS01 AKG 1.14.11.77 GO:0005737 ... Q9WWU5 15023059
    48 1oik:A (2.06) BS02 AKG 1.14.11.77 GO:0005737 ... Q9WWU5 15023059
    49 1oik:D (2.06) BS01 AKG 1.14.11.77 GO:0005737 ... Q9WWU5 15023059
    50 1os7:A (2.5) BS02 AKG 1.14.11.17 GO:0000908 ... P37610 12741810
    51 1os7:B (2.5) BS02 AKG 1.14.11.17 GO:0000908 ... P37610 12741810
    52 1os7:C (2.5) BS02 AKG 1.14.11.17 GO:0000908 ... P37610 12741810
    53 1os7:D (2.5) BS02 AKG 1.14.11.17 GO:0000908 ... P37610 12741810
    54 1rxg:A (1.5) BS02 AKG 1.14.20.1 GO:0005506 ... P18548 9723623
    55 1unb:A (1.5) BS02 AKG 1.14.20.1 GO:0005506 ... P18548 14718929
    56 1uob:A (1.7) BS03 AKG 1.14.20.1 GO:0005506 ... P18548 14718929
    57 1yba:A (2.24) BS02 AKG 1.1.1.399
    1.1.1.95
    GO:0004617 ... P0A9T0 15823035
    58 1yba:B (2.24) BS01 AKG 1.1.1.399
    1.1.1.95
    GO:0004617 ... P0A9T0 15823035
    59 1yba:C (2.24) BS01 AKG 1.1.1.399
    1.1.1.95
    GO:0004617 ... P0A9T0 15823035
    60 1yba:D (2.24) BS01 AKG 1.1.1.399
    1.1.1.95
    GO:0004617 ... P0A9T0 15823035
    61 2a1x:A (2.5) BS02 AKG 1.14.11.18 GO:0001561 ... O14832 16186124
    62 2brt:A (2.2) BS02 AKG 1.14.20.4 GO:0007033 ... Q96323 16106293
    63 2cjh:A (2.0) BS02 AKG 2.6.1.36 GO:0003867 ... P9WQ77 16950391
    64 2fct:A (1.6) BS04 AKG 1.14.20.15 GO:0016491 ... Q9RBY6 16541079
    65 2fct:B (1.6) BS03 AKG 1.14.20.15 GO:0016491 ... Q9RBY6 16541079
    66 2fcu:A (1.6) BS02 AKG 1.14.20.15 GO:0016491 ... Q9RBY6 16541079
    67 2fcu:B (1.6) BS01 AKG 1.14.20.15 GO:0016491 ... Q9RBY6 16541079
    68 2fcv:A (1.8) BS03 AKG 1.14.20.15 GO:0016491 ... Q9RBY6 16541079
    69 2fcv:B (1.8) BS02 AKG 1.14.20.15 GO:0016491 ... Q9RBY6 16541079
    70 2fd8:A (2.3) BS03 AKG 1.14.11.33 GO:0005515 ... P05050 16482161
    71 2fdf:A (2.1) BS03 AKG 1.14.11.33 GO:0005515 ... P05050 16482161
    72 2fdh:A (2.1) BS03 AKG 1.14.11.33 GO:0005515 ... P05050 16482161
    73 2fdi:A (1.8) BS03 AKG 1.14.11.33 GO:0005515 ... P05050 16482161
    74 2fdk:A (2.3) BS03 AKG 1.14.11.33 GO:0005515 ... P05050 16482161
    75 2gp5:A (2.28) BS03 AKG 1.14.11.66
    1.14.11.69
    N/A O75164 16677698
    76 2gp5:B (2.28) BS03 AKG 1.14.11.66
    1.14.11.69
    N/A O75164 16677698
    77 2ilm:A (2.3) BS04 AKG 1.14.11.30
    1.14.11.n4
    GO:0003714 ... Q9NWT6 18611856
    78 2iuw:A (1.5) BS04 AKG 1.14.11.33
    1.14.11.54
    GO:0006281 ... Q96Q83 16858410
    79 2j9e:C (1.62) BS03 AKG ? GO:0005515 ... Q60381 17203075
    80 2jjh:A (2.7) BS02 AKG 2.6.1.36 GO:0003867 ... P9WQ77 26003725
    81 2q8c:A (2.047) BS03 AKG 1.14.11.66
    1.14.11.69
    N/A O75164 17589523
    82 2q8c:B (2.047) BS03 AKG 1.14.11.66
    1.14.11.69
    N/A O75164 17589523
    83 2qfx:A (2.7) BS03 AKG 1.1.1.42 GO:0000287 ... P21954 18552125
    84 2qfx:B (2.7) BS03 AKG 1.1.1.42 GO:0000287 ... P21954 18552125
    85 2qfx:C (2.7) BS03 AKG 1.1.1.42 GO:0000287 ... P21954 18552125
    86 2qfx:D (2.7) BS04 AKG 1.1.1.42 GO:0000287 ... P21954 18552125
    87 2qfx:E (2.7) BS03 AKG 1.1.1.42 GO:0000287 ... P21954 18552125
    88 2qfx:F (2.7) BS04 AKG 1.1.1.42 GO:0000287 ... P21954 18552125
    89 2qfy:A (2.1) BS01 AKG 1.1.1.42 GO:0000287 ... P21954 18552125
    90 2qfy:B (2.1) BS01 AKG 1.1.1.42 GO:0000287 ... P21954 18552125
    91 2qfy:C (2.1) BS01 AKG 1.1.1.42 GO:0000287 ... P21954 18552125
    92 2qfy:D (2.1) BS01 AKG 1.1.1.42 GO:0000287 ... P21954 18552125
    93 2qfy:E (2.1) BS01 AKG 1.1.1.42 GO:0000287 ... P21954 18552125
    94 2qfy:F (2.1) BS01 AKG 1.1.1.42 GO:0000287 ... P21954 18552125
    95 2rdn:A (1.35) BS02 AKG 1.14.11.35 GO:0005506 ... Q82IZ1 17942405
    96 2rdq:A (1.31) BS02 AKG 1.14.11.35 GO:0005506 ... Q82IZ1 17942405
    97 2vdc:A (9.5) BS03 AKG 1.4.1.13 GO:0004355 ... Q05755 18199747
    98 2vdc:B (9.5) BS03 AKG 1.4.1.13 GO:0004355 ... Q05755 18199747
    99 2vdc:C (9.5) BS03 AKG 1.4.1.13 GO:0004355 ... Q05755 18199747
    100 2vdc:D (9.5) BS03 AKG 1.4.1.13 GO:0004355 ... Q05755 18199747
    101 2vdc:E (9.5) BS03 AKG 1.4.1.13 GO:0004355 ... Q05755 18199747
    102 2vdc:F (9.5) BS03 AKG 1.4.1.13 GO:0004355 ... Q05755 18199747
    103 2xgx:A (2.85) BS01 AKG ? GO:0003677 ... P29283 20716687
    104 2xgx:B (2.85) BS01 AKG ? GO:0003677 ... P29283 20716687
    105 2xhk:A (2.3) BS01 AKG ? GO:0003677 ... P29283 20716687
    106 2xhk:B (2.3) BS01 AKG ? GO:0003677 ... P29283 20716687
    107 2xko:A (2.25) BS01 AKG ? GO:0003677 ... P29283 20716687
    108 2xko:B (2.25) BS01 AKG ? GO:0003677 ... P29283 20716687
    109 2xkp:A (3.05) BS01 AKG ? GO:0003677 ... P29283 20716687
    110 2xkp:B (3.05) BS01 AKG ? GO:0003677 ... P29283 20716687
    111 2xkp:C (3.05) BS01 AKG ? GO:0003677 ... P29283 20716687
    112 2xkp:D (3.05) BS01 AKG ? GO:0003677 ... P29283 20716687
    113 2xkp:E (3.05) BS01 AKG ? GO:0003677 ... P29283 20716687
    114 2xkp:F (3.05) BS01 AKG ? GO:0003677 ... P29283 20716687
    115 2xue:A (2.0) BS03 AKG 1.14.11.68 N/A O15054 22842901
    116 2xue:B (2.0) BS03 AKG 1.14.11.68 N/A O15054 22842901
    117 2xul:A (2.2) BS02 AKG ? GO:0000166 ... P0A3F4 21041661
    118 2xul:B (2.2) BS03 AKG ? GO:0000166 ... P0A3F4 21041661
    119 2xul:C (2.2) BS03 AKG ? GO:0000166 ... P0A3F4 21041661
    120 2xul:D (2.2) BS02 AKG ? GO:0000166 ... P0A3F4 21041661
    121 2xul:E (2.2) BS03 AKG ? GO:0000166 ... P0A3F4 21041661
    122 2xul:F (2.2) BS03 AKG ? GO:0000166 ... P0A3F4 21041661
    123 2xzw:A (1.95) BS02 AKG ? GO:0000166 ... P0A3F4 21041661 PDBbind: -logKd/Ki=5.29, Kd=5.1uM
    124 2xzw:B (1.95) BS03 AKG ? GO:0000166 ... P0A3F4 21041661 PDBbind: -logKd/Ki=5.29, Kd=5.1uM
    125 2xzw:C (1.95) BS03 AKG ? GO:0000166 ... P0A3F4 21041661
    126 2xzw:F (1.95) BS03 AKG ? GO:0000166 ... P0A3F4 21041661
    127 2xzw:H (1.95) BS03 AKG ? GO:0000166 ... P0A3F4 21041661
    128 2xzw:I (1.95) BS03 AKG ? GO:0000166 ... P0A3F4 21041661
    129 2y0i:A (2.28) BS03 AKG 1.14.11.30
    1.14.11.n4
    GO:0003714 ... Q9NWT6 21251231
    130 2ykx:A (1.85) BS02 AKG ? GO:0008483 ... A3EYF7 22745123
    131 2ykx:A (1.85) BS04 AKG ? GO:0008483 ... A3EYF7 22745123
    132 2ykx:B (1.85) BS02 AKG ? GO:0008483 ... A3EYF7 22745123
    133 2ykx:B (1.85) BS04 AKG ? GO:0008483 ... A3EYF7 22745123
    134 2ykx:C (1.85) BS02 AKG ? GO:0008483 ... A3EYF7 22745123
    135 2yu1:A (2.7) BS02 AKG 1.14.11.27 N/A Q9Y2K7 N/A
    136 2ze3:A (1.65) BS01 AKG N/A GO:0003824 ... N/A 18433062 MOAD: Ki=0.9mM
    137 2ztj:A (1.8) BS01 AKG 2.3.3.14 GO:0003824 ... O87198 19996101
    138 2zyf:A (2.15) BS01 AKG 2.3.3.14 GO:0003824 ... O87198 19996101
    139 3al6:B (2.8) BS01 AKG 1.14.11.42 GO:0000049 ... A2RUC4 20972222
    140 3al6:D (2.8) BS01 AKG 1.14.11.42 GO:0000049 ... A2RUC4 20972222
    141 3aow:C (1.56) BS01 AKG 2.6.1.7 GO:0008483 ... O57946 N/A
    142 3aow:C (1.56) BS03 AKG 2.6.1.7 GO:0008483 ... O57946 N/A
    143 3ath:A (1.69) BS02 AKG 2.6.1.7 GO:0008483 ... O57946 N/A
    144 3ath:A (1.69) BS03 AKG 2.6.1.7 GO:0008483 ... O57946 N/A
    145 3ath:C (1.69) BS02 AKG 2.6.1.7 GO:0008483 ... O57946 N/A
    146 3bi3:A (1.9) BS04 AKG 1.14.11.33 GO:0005515 ... P05050 18432238
    147 3bie:A (1.68) BS04 AKG 1.14.11.33 GO:0005515 ... P05050 18432238
    148 3bkz:A (1.65) BS04 AKG 1.14.11.33 GO:0005515 ... P05050 18432238
    149 3bn1:A (1.8) BS01 AKG 2.6.1.102 GO:0000271 ... Q9A9H3 18247575
    150 3bn1:B (1.8) BS01 AKG 2.6.1.102 GO:0000271 ... Q9A9H3 18247575
    151 3bu0:A (2.5) BS03 AKG 1.14.11.33 GO:0006281 ... Q6NS38 18432238
    152 3buc:A (2.59) BS04 AKG 1.14.11.33 GO:0006281 ... Q6NS38 18432238
    153 3d8c:A (2.1) BS03 AKG 1.14.11.30
    1.14.11.n4
    GO:0003714 ... Q9NWT6 18611856
    154 3gjb:A (2.2) BS02 AKG ? GO:0016491 ... D0VX22 19281171
    155 3gjb:A (2.2) BS03 AKG ? GO:0016491 ... D0VX22 19281171
    156 3gjb:B (2.2) BS02 AKG ? GO:0016491 ... D0VX22 19281171
    157 3gr9:A (2.2) BS01 AKG ? GO:0000271 ... B1B4V9 19402712
    158 3gr9:A (2.2) BS02 AKG ? GO:0000271 ... B1B4V9 19402712
    159 3gr9:B (2.2) BS01 AKG ? GO:0000271 ... B1B4V9 19402712
    160 3gr9:B (2.2) BS02 AKG ? GO:0000271 ... B1B4V9 19402712
    161 3gr9:C (2.2) BS01 AKG ? GO:0000271 ... B1B4V9 19402712
    162 3gr9:C (2.2) BS02 AKG ? GO:0000271 ... B1B4V9 19402712
    163 3gr9:D (2.2) BS01 AKG ? GO:0000271 ... B1B4V9 19402712
    164 3gr9:D (2.2) BS02 AKG ? GO:0000271 ... B1B4V9 19402712
    165 3gr9:E (2.2) BS01 AKG ? GO:0000271 ... B1B4V9 19402712
    166 3gr9:F (2.2) BS01 AKG ? GO:0000271 ... B1B4V9 19402712
    167 3gr9:G (2.2) BS01 AKG ? GO:0000271 ... B1B4V9 19402712
    168 3gr9:H (2.2) BS01 AKG ? GO:0000271 ... B1B4V9 19402712
    169 3hww:A (1.95) BS01 AKG 2.2.1.9 GO:0000287 ... P17109 19703421 MOAD: Kd=75nM
    PDBbind: -logKd/Ki=7.12, Kd=75nM
    170 3hww:D (1.95) BS01 AKG 2.2.1.9 GO:0000287 ... P17109 19703421 MOAD: Kd=75nM
    PDBbind: -logKd/Ki=7.12, Kd=75nM
    171 3i2o:A (1.7) BS02 AKG 1.14.11.33 GO:0005515 ... P05050 19706517
    172 3i3m:A (1.5) BS02 AKG 1.14.11.33 GO:0005515 ... P05050 19706517
    173 3i3q:A (1.4) BS01 AKG 1.14.11.33 GO:0005515 ... P05050 19706517
    174 3i3q:B (1.4) BS01 AKG 1.14.11.33 GO:0005515 ... P05050 19706517
    175 3i49:A (1.6) BS02 AKG 1.14.11.33 GO:0005515 ... P05050 19706517
    176 3inm:A (2.1) BS02 AKG 1.1.1.42 GO:0000287 ... O75874 19935646
    177 3inm:B (2.1) BS03 AKG 1.1.1.42 GO:0000287 ... O75874 19935646
    178 3inm:C (2.1) BS02 AKG 1.1.1.42 GO:0000287 ... O75874 19935646
    179 3ivt:A (2.67) BS02 AKG 2.3.3.14 GO:0003824 ... Q9Y823 19776021
    180 3ivt:B (2.67) BS02 AKG 2.3.3.14 GO:0003824 ... Q9Y823 19776021
    181 3ivu:A (2.72) BS02 AKG 2.3.3.14 GO:0003824 ... Q9Y823 19776021
    182 3ivu:B (2.72) BS02 AKG 2.3.3.14 GO:0003824 ... Q9Y823 19776021
    183 3k3o:A (2.1) BS01 AKG 1.14.11.27
    1.14.11.65
    N/A Q9UPP1 20101266
    184 3khb:A (2.9) BS02 AKG 1.14.11.33 GO:0005515 ... P05050 20084272
    185 3khb:B (2.9) BS02 AKG 1.14.11.33 GO:0005515 ... P05050 20084272
    186 3khc:A (2.2) BS02 AKG 1.14.11.33 GO:0005515 ... P05050 20084272
    187 3khc:B (2.2) BS03 AKG 1.14.11.33 GO:0005515 ... P05050 20084272
    188 3kt7:A (1.77) BS02 AKG 1.14.11.- GO:0000288 ... P40032 20040577
    189 3kv6:A (2.89) BS04 AKG 1.14.11.65 N/A Q6ZMT4 20023638
    190 3kv6:D (2.89) BS04 AKG 1.14.11.65 N/A Q6ZMT4 20023638
    191 3kva:A (2.79) BS03 AKG 1.14.11.65 N/A Q6ZMT4 20023638
    192 3la2:A (2.6) BS01 AKG ? GO:0003677 ... P0A4U6 20616047
    193 3la2:B (2.6) BS01 AKG ? GO:0003677 ... P0A4U6 20616047
    194 3ldb:A (2.7) BS01 AKG 1.14.11.- N/A Q6NYC1 20679243
    195 3mhy:A (1.4) BS02 AKG ? GO:0005524 ... P70731 20493877
    196 3mhy:B (1.4) BS02 AKG ? GO:0005524 ... P70731 20493877
    197 3mhy:C (1.4) BS03 AKG ? GO:0005524 ... P70731 20493877
    198 3nnf:A (2.201) BS02 AKG ? N/A Q6DNF2 20660778
    199 3nnl:A (2.883) BS02 AKG ? N/A Q6DNF2 20660778
    200 3o1m:A (1.75) BS04 AKG 1.14.11.33 GO:0005515 ... P05050 21068844

    Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).
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