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BioLiP
Download all results in tab-seperated text for 41 receptor-ligand interactions, whose format is explained at readme.txt.
  • Hover over PDB to view the title of the structure. Click PDB to view the structure at the RCSB PDB database. Resolution -1.00 means the resolution is unavailable, e.g., for NMR structures.
  • Click Site # to view the binding site structure. Hover over Site # to view the binding residues.
  • Hover over Ligand to view the full ligand name. Click Ligand to view the 2D diagram and other detail information of the ligand.
  • Hover over EC number to view the full name of enzymatic activity.
  • Hover over GO terms to view all GO terms.
  • Hover over UniProt to view the protein name.

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    # PDB
    (Resolution Å)     		Site # Ligand EC number GO terms UniProt PubMed Binding
    affinity
    1 1epb:A (2.2) BS01 9CR ? GO:0005576 ... P06911 8069623
    2 1epb:B (2.2) BS01 9CR ? GO:0005576 ... P06911 8069623
    3 1fby:A (2.25) BS01 9CR ? GO:0003677 ... P19793 10835357 MOAD: Kd=1.5nM
    BindingDB: EC50=100nM, Ki=583nM, IC50=32nM, Kd=240nM
    4 1fby:B (2.25) BS01 9CR ? GO:0003677 ... P19793 10835357 MOAD: Kd=1.5nM
    BindingDB: EC50=100nM, Ki=583nM, IC50=32nM, Kd=240nM
    5 1fm6:A (2.1) BS02 9CR ? GO:0003677 ... P19793 10882139 BindingDB: EC50=100nM, Ki=583nM, IC50=32nM, Kd=240nM
    6 1fm6:U (2.1) BS02 9CR ? GO:0003677 ... P19793 10882139 BindingDB: EC50=100nM, Ki=583nM, IC50=32nM, Kd=240nM
    7 1fm9:A (2.1) BS02 9CR ? GO:0003677 ... P19793 10882139 BindingDB: EC50=100nM, Ki=583nM, IC50=32nM, Kd=240nM
    8 1k74:A (2.3) BS02 9CR ? GO:0003677 ... P19793 11698662 BindingDB: EC50=100nM, Ki=583nM, IC50=32nM, Kd=240nM
    9 1tyr:A (1.8) BS01 9CR ? GO:0005179 ... P02766 8536704 MOAD: Kd=0.1uM
    10 1tyr:B (1.8) BS01 9CR ? GO:0005179 ... P02766 8536704 MOAD: Kd=0.1uM
    11 1xdk:A (2.9) BS02 9CR ? GO:0003677 ... P28700 15528208 BindingDB: IC50=82nM, Kd=32nM, EC50=200nM
    12 1xdk:B (2.9) BS02 9CR ? GO:0003677 ... P22605 15528208 BindingDB: Kd=7nM
    13 1xdk:E (2.9) BS02 9CR ? GO:0003677 ... P28700 15528208 BindingDB: IC50=82nM, Kd=32nM, EC50=200nM
    14 1xdk:F (2.9) BS02 9CR ? GO:0003677 ... P22605 15528208 BindingDB: Kd=7nM
    15 1xiu:A (2.5) BS02 9CR ? GO:0003677 ... Q8T5C6 16274693
    16 1xiu:B (2.5) BS02 9CR ? GO:0003677 ... Q8T5C6 16274693
    17 1xls:A (2.96) BS02 9CR ? GO:0003677 ... P19793 15610733 BindingDB: EC50=100nM, Ki=583nM, IC50=32nM, Kd=240nM
    18 1xls:B (2.96) BS03 9CR ? GO:0003677 ... P19793 15610733 BindingDB: EC50=100nM, Ki=583nM, IC50=32nM, Kd=240nM
    19 1xls:C (2.96) BS02 9CR ? GO:0003677 ... P19793 15610733 BindingDB: EC50=100nM, Ki=583nM, IC50=32nM, Kd=240nM
    20 1xls:D (2.96) BS02 9CR ? GO:0003677 ... P19793 15610733 BindingDB: EC50=100nM, Ki=583nM, IC50=32nM, Kd=240nM
    21 2nnh:A (2.6) BS02 9CR 1.14.14.1 GO:0002933 ... P10632 18413310
    22 2nnh:A (2.6) BS03 9CR 1.14.14.1 GO:0002933 ... P10632 18413310
    23 2nnh:B (2.6) BS02 9CR 1.14.14.1 GO:0002933 ... P10632 18413310
    24 2nnh:B (2.6) BS03 9CR 1.14.14.1 GO:0002933 ... P10632 18413310
    25 3dzu:A (3.2) BS06 9CR ? GO:0000122 ... P19793 19043829 BindingDB: EC50=100nM, Ki=583nM, IC50=32nM, Kd=240nM
    26 3dzy:A (3.1) BS04 9CR ? GO:0000122 ... P19793 19043829 BindingDB: EC50=100nM, Ki=583nM, IC50=32nM, Kd=240nM
    27 3e00:A (3.1) BS06 9CR ? GO:0000122 ... P19793 19043829 BindingDB: EC50=100nM, Ki=583nM, IC50=32nM, Kd=240nM
    28 3lbd:A (2.4) BS01 9CR ? GO:0003677 ... P13631 9501913 BindingDB: EC50=45nM, Kd=148nM, Ki=20nM, IC50=17nM
    29 3oap:A (2.05) BS02 9CR ? GO:0003677 ... P19793 21049972 MOAD: Kd=14nM
    BindingDB: EC50=100nM, Ki=583nM, IC50=32nM, Kd=240nM
    30 3uvv:B (2.95) BS01 9CR ? GO:0003677 ... P19793 22474364 BindingDB: EC50=100nM, Ki=583nM, IC50=32nM, Kd=240nM
    31 4nqa:A (3.102) BS04 9CR ? GO:0003677 ... P19793 24561505 BindingDB: EC50=100nM, Ki=583nM, IC50=32nM, Kd=240nM
    32 4nqa:H (3.102) BS04 9CR ? GO:0003677 ... P19793 24561505 BindingDB: EC50=100nM, Ki=583nM, IC50=32nM, Kd=240nM
    33 5ji0:A (1.98) BS02 9CR ? GO:0003677 ... P19793 N/A BindingDB: EC50=100nM, Ki=583nM, IC50=32nM, Kd=240nM
    34 5m24:A (1.69) BS01 9CR ? GO:0003677 ... P13631 28125680 BindingDB: EC50=45nM, Kd=148nM, Ki=20nM, IC50=17nM
    35 5uan:A (3.508) BS05 9CR ? GO:0003677 ... P19793 29021580 BindingDB: EC50=100nM, Ki=583nM, IC50=32nM, Kd=240nM
    36 5z12:B (2.75) BS02 9CR ? GO:0003677 ... P19793 29934308 BindingDB: EC50=100nM, Ki=583nM, IC50=32nM, Kd=240nM
    37 5z12:C (2.75) BS02 9CR ? GO:0003677 ... P19793 29934308 BindingDB: EC50=100nM, Ki=583nM, IC50=32nM, Kd=240nM
    38 6a5y:D (2.1) BS02 9CR ? GO:0003677 ... P19793 30275017 BindingDB: EC50=100nM, Ki=583nM, IC50=32nM, Kd=240nM
    39 6a5z:D (2.95) BS02 9CR ? GO:0003677 ... P19793 30275017 BindingDB: EC50=100nM, Ki=583nM, IC50=32nM, Kd=240nM
    40 6a5z:L (2.95) BS02 9CR ? GO:0003677 ... P19793 30275017 BindingDB: EC50=100nM, Ki=583nM, IC50=32nM, Kd=240nM
    41 6a60:D (3.05) BS02 9CR ? GO:0003677 ... P19793 30275017 BindingDB: EC50=100nM, Ki=583nM, IC50=32nM, Kd=240nM
    Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).

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