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BioLiP
Download all results in tab-seperated text for 817662 receptor-ligand interactions, whose format is explained at readme.txt.
  • Hover over PDB to view the title of the structure. Click PDB to view the structure at the RCSB PDB database. Resolution -1.00 means the resolution is unavailable, e.g., for NMR structures.
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  • Hover over Ligand to view the full ligand name. Click Ligand to view the 2D diagram and other detail information of the ligand.
  • Hover over EC number to view the full name of enzymatic activity.
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    # PDB
    (Resolution Å)
    Site # Ligand EC number GO terms UniProt PubMed Binding
    affinity
    16201 1h1c:B (2.85) BS01 PLP 2.6.1.9 GO:0000105 ... Q9X0D0 15007066
    16202 1h1c:C (2.85) BS01 PLP 2.6.1.9 GO:0000105 ... Q9X0D0 15007066
    16203 1h1c:D (2.85) BS01 PLP 2.6.1.9 GO:0000105 ... Q9X0D0 15007066
    16204 1h1d:A (2.0) BS01 MG 2.1.1.6 GO:0000287 ... P22734 12237326
    16205 1h1d:A (2.0) BS02 SAM 2.1.1.6 GO:0000287 ... P22734 12237326
    16206 1h1d:A (2.0) BS03 BIA 2.1.1.6 GO:0000287 ... P22734 12237326 MOAD: Ki=6nM
    PDBbind: -logKd/Ki=8.22, Ki=6.0nM
    16207 1h1h:A (2.0) BS01 A2P 3.1.27.- GO:0001530 ... P12724 12356310 MOAD: Ki~6.5uM
    PDBbind: -logKd/Ki=5.22, Ki=6uM
    16208 1h1i:A (1.75) BS01 CU 1.13.11.24 GO:0008127 ... Q7SIC2 12486225
    16209 1h1i:A (1.75) BS02 QUE 1.13.11.24 GO:0008127 ... Q7SIC2 12486225
    16210 1h1i:B (1.75) BS01 CU 1.13.11.24 GO:0008127 ... Q7SIC2 12486225
    16211 1h1i:B (1.75) BS02 QUE 1.13.11.24 GO:0008127 ... Q7SIC2 12486225
    16212 1h1i:C (1.75) BS01 CU 1.13.11.24 GO:0008127 ... Q7SIC2 12486225
    16213 1h1i:C (1.75) BS02 QUE 1.13.11.24 GO:0008127 ... Q7SIC2 12486225
    16214 1h1i:D (1.75) BS01 CU 1.13.11.24 GO:0008127 ... Q7SIC2 12486225
    16215 1h1i:D (1.75) BS02 QUE 1.13.11.24 GO:0008127 ... Q7SIC2 12486225
    16216 1h1l:A (1.9) BS01 CFM 1.18.6.1 GO:0005524 ... P00466 12133839
    16217 1h1l:A (1.9) BS02 CLF 1.18.6.1 GO:0005524 ... P00466 12133839
    16218 1h1l:B (1.9) BS01 CLF 1.18.6.1 GO:0005524 ... P09772 12133839
    16219 1h1l:B (1.9) BS02 MG 1.18.6.1 GO:0005524 ... P09772 12133839
    16220 1h1l:B (1.9) BS03 MG 1.18.6.1 GO:0005524 ... P09772 12133839
    16221 1h1l:C (1.9) BS01 CFM 1.18.6.1 GO:0005524 ... P00466 12133839
    16222 1h1l:C (1.9) BS02 CLF 1.18.6.1 GO:0005524 ... P00466 12133839
    16223 1h1l:D (1.9) BS01 MG 1.18.6.1 GO:0005524 ... P09772 12133839
    16224 1h1l:D (1.9) BS02 MG 1.18.6.1 GO:0005524 ... P09772 12133839
    16225 1h1l:D (1.9) BS03 CLF 1.18.6.1 GO:0005524 ... P09772 12133839
    16226 1h1m:A (1.9) BS01 KMP 1.13.11.24 GO:0008127 ... Q7SIC2 12486225
    16227 1h1m:A (1.9) BS02 CU 1.13.11.24 GO:0008127 ... Q7SIC2 12486225
    16228 1h1m:B (1.9) BS01 KMP 1.13.11.24 GO:0008127 ... Q7SIC2 12486225
    16229 1h1m:B (1.9) BS02 CU 1.13.11.24 GO:0008127 ... Q7SIC2 12486225
    16230 1h1m:C (1.9) BS01 KMP 1.13.11.24 GO:0008127 ... Q7SIC2 12486225
    16231 1h1m:C (1.9) BS02 CU 1.13.11.24 GO:0008127 ... Q7SIC2 12486225
    16232 1h1m:D (1.9) BS01 KMP 1.13.11.24 GO:0008127 ... Q7SIC2 12486225
    16233 1h1m:D (1.9) BS02 CU 1.13.11.24 GO:0008127 ... Q7SIC2 12486225
    16234 1h1o:A (2.13) BS01 HEM ? GO:0005506 ... P74917 12737820
    16235 1h1o:A (2.13) BS02 HEM ? GO:0005506 ... P74917 12737820
    16236 1h1o:B (2.13) BS01 HEM ? GO:0005506 ... P74917 12737820
    16237 1h1o:B (2.13) BS02 HEM ? GO:0005506 ... P74917 12737820
    16238 1h1p:A (2.1) BS01 CMG 2.7.11.22 GO:0000082 ... P24941 12244298 MOAD: Ki=12uM
    PDBbind: -logKd/Ki=4.92, Ki=12uM
    BindingDB: IC50=17000nM
    16239 1h1p:C (2.1) BS01 CMG 2.7.11.22 GO:0000082 ... P24941 12244298 MOAD: Ki=12uM
    BindingDB: IC50=17000nM
    16240 1h1q:A (2.5) BS01 2A6 2.7.11.22 GO:0000082 ... P24941 12244298 MOAD: ic50=1uM
    PDBbind: -logKd/Ki=6.00, IC50=1.0uM
    BindingDB: IC50=2300nM
    16241 1h1q:C (2.5) BS01 2A6 2.7.11.22 GO:0000082 ... P24941 12244298 MOAD: ic50=1uM
    BindingDB: IC50=2300nM
    16242 1h1r:A (2.0) BS01 6CP 2.7.11.22 GO:0000082 ... P24941 12244298 MOAD: ic50=2.3uM
    PDBbind: -logKd/Ki=5.64, IC50=2.3uM
    BindingDB: IC50=2300nM
    16243 1h1r:C (2.0) BS01 6CP 2.7.11.22 GO:0000082 ... P24941 12244298 MOAD: ic50=2.3uM
    BindingDB: IC50=2300nM
    16244 1h1s:A (2.0) BS01 4SP 2.7.11.22 GO:0000082 ... P24941 12244298 MOAD: Ki=6nM
    PDBbind: -logKd/Ki=8.22, Ki=6nM
    BindingDB: IC50=6.0nM, Ki=6.0nM, Kd=1310nM
    16245 1h1s:C (2.0) BS01 4SP 2.7.11.22 GO:0000082 ... P24941 12244298 MOAD: Ki=6nM
    BindingDB: IC50=6.0nM, Ki=6.0nM, Kd=1310nM
    16246 1h1t:A (1.78) BS01 COA 2.7.7.3 GO:0003824 ... P0A6I6 12837781
    16247 1h1t:B (1.78) BS01 PNS 2.7.7.3 GO:0003824 ... P0A6I6 12837781
    16248 1h1v:A (2.99) BS01 ATP 3.6.4.- GO:0000287 ... P68135 12460571
    16249 1h1v:G (2.99) BS01 CA ? GO:0051015 ... P06396 12460571
    16250 1h1v:G (2.99) BS02 CA ? GO:0051015 ... P06396 12460571
    16251 1h1v:G (2.99) BS03 CA ? GO:0051015 ... P06396 12460571
    16252 1h1v:G (2.99) BS04 CA ? GO:0051015 ... P06396 12460571
    16253 1h1w:A (2.0) BS01 SO4 2.7.11.1 GO:0004672 ... O15530 12169624
    16254 1h1w:A (2.0) BS02 SO4 2.7.11.1 GO:0004672 ... O15530 12169624
    16255 1h1w:A (2.0) BS03 ATP 2.7.11.1 GO:0004672 ... O15530 12169624
    16256 1h1x:A (1.4) BS01 HEM 1.11.1.-
    1.7.-.-
    GO:0004601 ... P02185 14563209
    16257 1h1x:A (1.4) BS02 CYN 1.11.1.-
    1.7.-.-
    GO:0004601 ... P02185 14563209
    16258 1h1y:B (1.87) BS01 SO4 5.1.3.1 GO:0004750 ... Q9SE42 12547196
    16259 1h1z:A (3.4) BS01 ZN 5.1.3.1 GO:0004750 ... Q9SE42 12547196
    16260 1h1z:A (3.4) BS02 SO4 5.1.3.1 GO:0004750 ... Q9SE42 12547196
    16261 1h1z:B (3.4) BS01 ZN 5.1.3.1 GO:0004750 ... Q9SE42 12547196
    16262 1h1z:B (3.4) BS02 SO4 5.1.3.1 GO:0004750 ... Q9SE42 12547196
    16263 1h21:A (2.5) BS01 HEC ? GO:0009061 ... P81040 12589573
    16264 1h21:A (2.5) BS02 HEC ? GO:0009061 ... P81040 12589573
    16265 1h21:A (2.5) BS03 HEC ? GO:0009061 ... P81040 12589573
    16266 1h21:A (2.5) BS04 HEC ? GO:0009061 ... P81040 12589573
    16267 1h21:B (2.5) BS01 HEC ? GO:0009061 ... P81040 12589573
    16268 1h21:B (2.5) BS02 HEC ? GO:0009061 ... P81040 12589573
    16269 1h21:B (2.5) BS03 HEC ? GO:0009061 ... P81040 12589573
    16270 1h21:B (2.5) BS04 HEC ? GO:0009061 ... P81040 12589573
    16271 1h21:C (2.5) BS01 HEC ? GO:0009061 ... P81040 12589573
    16272 1h21:C (2.5) BS02 HEC ? GO:0009061 ... P81040 12589573
    16273 1h21:C (2.5) BS03 HEC ? GO:0009061 ... P81040 12589573
    16274 1h21:C (2.5) BS04 HEC ? GO:0009061 ... P81040 12589573
    16275 1h21:D (2.5) BS01 HEC ? GO:0009061 ... P81040 12589573
    16276 1h21:D (2.5) BS02 HEC ? GO:0009061 ... P81040 12589573
    16277 1h21:D (2.5) BS03 HEC ? GO:0009061 ... P81040 12589573
    16278 1h21:D (2.5) BS04 HEC ? GO:0009061 ... P81040 12589573
    16279 1h22:A (2.15) BS01 E10 3.1.1.7 GO:0001507 ... P04058 12517147 MOAD: Ki=0.8nM
    PDBbind: -logKd/Ki=9.10, Ki=0.8nM
    BindingDB: Ki=0.8nM, IC50=2.4nM
    16280 1h23:A (2.15) BS01 E12 3.1.1.7 GO:0001507 ... P04058 12517147 MOAD: Ki=4.5nM
    PDBbind: -logKd/Ki=8.35, Ki=4.5nM
    BindingDB: Ki=4.5nM, IC50=16.0nM
    16281 1h24:B (2.5) BS01 peptide ? GO:0016538 ... P20248 12501191
    16282 1h25:B (2.5) BS01 peptide ? GO:0016538 ... P20248 12501191
    16283 1h26:B (2.24) BS01 peptide ? GO:0016538 ... P20248 12501191
    16284 1h27:B (2.2) BS01 peptide ? GO:0016538 ... P20248 12501191
    16285 1h28:B (2.8) BS01 peptide ? GO:0016538 ... P20248 12501191
    16286 1h28:D (2.8) BS01 peptide ? GO:0016538 ... P20248 12501191
    16287 1h29:A (2.51) BS01 HEC ? GO:0009055 ... P24092 12356749
    16288 1h29:A (2.51) BS02 HEC ? GO:0009055 ... P24092 12356749
    16289 1h29:A (2.51) BS03 HEC ? GO:0009055 ... P24092 12356749
    16290 1h29:A (2.51) BS04 HEC ? GO:0009055 ... P24092 12356749
    16291 1h29:A (2.51) BS05 HEC ? GO:0009055 ... P24092 12356749
    16292 1h29:A (2.51) BS06 HEC ? GO:0009055 ... P24092 12356749
    16293 1h29:A (2.51) BS07 HEC ? GO:0009055 ... P24092 12356749
    16294 1h29:A (2.51) BS08 HEC ? GO:0009055 ... P24092 12356749
    16295 1h29:A (2.51) BS09 HEC ? GO:0009055 ... P24092 12356749
    16296 1h29:A (2.51) BS10 HEC ? GO:0009055 ... P24092 12356749
    16297 1h29:A (2.51) BS11 HEC ? GO:0009055 ... P24092 12356749
    16298 1h29:A (2.51) BS12 HEC ? GO:0009055 ... P24092 12356749
    16299 1h29:A (2.51) BS13 HEC ? GO:0009055 ... P24092 12356749
    16300 1h29:A (2.51) BS14 HEC ? GO:0009055 ... P24092 12356749
    16301 1h29:A (2.51) BS15 HEC ? GO:0009055 ... P24092 12356749
    16302 1h29:A (2.51) BS16 HEC ? GO:0009055 ... P24092 12356749
    16303 1h29:B (2.51) BS01 HEC ? GO:0009055 ... P24092 12356749
    16304 1h29:B (2.51) BS02 HEC ? GO:0009055 ... P24092 12356749
    16305 1h29:B (2.51) BS03 HEC ? GO:0009055 ... P24092 12356749
    16306 1h29:B (2.51) BS04 HEC ? GO:0009055 ... P24092 12356749
    16307 1h29:B (2.51) BS05 HEC ? GO:0009055 ... P24092 12356749
    16308 1h29:B (2.51) BS06 HEC ? GO:0009055 ... P24092 12356749
    16309 1h29:B (2.51) BS07 HEC ? GO:0009055 ... P24092 12356749
    16310 1h29:B (2.51) BS08 HEC ? GO:0009055 ... P24092 12356749
    16311 1h29:B (2.51) BS09 HEC ? GO:0009055 ... P24092 12356749
    16312 1h29:B (2.51) BS10 HEC ? GO:0009055 ... P24092 12356749
    16313 1h29:B (2.51) BS11 HEC ? GO:0009055 ... P24092 12356749
    16314 1h29:B (2.51) BS12 HEC ? GO:0009055 ... P24092 12356749
    16315 1h29:B (2.51) BS13 HEC ? GO:0009055 ... P24092 12356749
    16316 1h29:B (2.51) BS14 HEC ? GO:0009055 ... P24092 12356749
    16317 1h29:B (2.51) BS15 HEC ? GO:0009055 ... P24092 12356749
    16318 1h29:B (2.51) BS16 HEC ? GO:0009055 ... P24092 12356749
    16319 1h29:C (2.51) BS01 HEC ? GO:0009055 ... P24092 12356749
    16320 1h29:C (2.51) BS02 HEC ? GO:0009055 ... P24092 12356749
    16321 1h29:C (2.51) BS03 HEC ? GO:0009055 ... P24092 12356749
    16322 1h29:C (2.51) BS04 HEC ? GO:0009055 ... P24092 12356749
    16323 1h29:C (2.51) BS05 HEC ? GO:0009055 ... P24092 12356749
    16324 1h29:C (2.51) BS06 HEC ? GO:0009055 ... P24092 12356749
    16325 1h29:C (2.51) BS07 HEC ? GO:0009055 ... P24092 12356749
    16326 1h29:C (2.51) BS08 HEC ? GO:0009055 ... P24092 12356749
    16327 1h29:C (2.51) BS09 HEC ? GO:0009055 ... P24092 12356749
    16328 1h29:C (2.51) BS10 HEC ? GO:0009055 ... P24092 12356749
    16329 1h29:C (2.51) BS11 HEC ? GO:0009055 ... P24092 12356749
    16330 1h29:C (2.51) BS12 HEC ? GO:0009055 ... P24092 12356749
    16331 1h29:C (2.51) BS13 HEC ? GO:0009055 ... P24092 12356749
    16332 1h29:C (2.51) BS14 HEC ? GO:0009055 ... P24092 12356749
    16333 1h29:C (2.51) BS15 HEC ? GO:0009055 ... P24092 12356749
    16334 1h29:C (2.51) BS16 HEC ? GO:0009055 ... P24092 12356749
    16335 1h29:D (2.51) BS01 HEC ? GO:0009055 ... P24092 12356749
    16336 1h29:D (2.51) BS02 HEC ? GO:0009055 ... P24092 12356749
    16337 1h29:D (2.51) BS03 HEC ? GO:0009055 ... P24092 12356749
    16338 1h29:D (2.51) BS04 HEC ? GO:0009055 ... P24092 12356749
    16339 1h29:D (2.51) BS05 HEC ? GO:0009055 ... P24092 12356749
    16340 1h29:D (2.51) BS06 HEC ? GO:0009055 ... P24092 12356749
    16341 1h29:D (2.51) BS07 HEC ? GO:0009055 ... P24092 12356749
    16342 1h29:D (2.51) BS08 HEC ? GO:0009055 ... P24092 12356749
    16343 1h29:D (2.51) BS09 HEC ? GO:0009055 ... P24092 12356749
    16344 1h29:D (2.51) BS10 HEC ? GO:0009055 ... P24092 12356749
    16345 1h29:D (2.51) BS11 HEC ? GO:0009055 ... P24092 12356749
    16346 1h29:D (2.51) BS12 HEC ? GO:0009055 ... P24092 12356749
    16347 1h29:D (2.51) BS13 HEC ? GO:0009055 ... P24092 12356749
    16348 1h29:D (2.51) BS14 HEC ? GO:0009055 ... P24092 12356749
    16349 1h29:D (2.51) BS15 HEC ? GO:0009055 ... P24092 12356749
    16350 1h29:D (2.51) BS16 HEC ? GO:0009055 ... P24092 12356749
    16351 1h2a:L (1.8) BS01 MG 1.12.2.1 GO:0008901 ... P21852 9438867
    16352 1h2a:L (1.8) BS02 NFE 1.12.2.1 GO:0008901 ... P21852 9438867
    16353 1h2a:S (1.8) BS01 SF4 1.12.2.1 GO:0008901 ... P21853 9438867
    16354 1h2a:S (1.8) BS02 SF4 1.12.2.1 GO:0008901 ... P21853 9438867
    16355 1h2a:S (1.8) BS03 F3S 1.12.2.1 GO:0008901 ... P21853 9438867
    16356 1h2b:A (1.62) BS01 OCA 1.1.1.1 GO:0000166 ... Q9Y9P9 12927540
    16357 1h2b:A (1.62) BS02 NAJ 1.1.1.1 GO:0000166 ... Q9Y9P9 12927540
    16358 1h2b:A (1.62) BS03 ZN 1.1.1.1 GO:0000166 ... Q9Y9P9 12927540
    16359 1h2b:A (1.62) BS04 ZN 1.1.1.1 GO:0000166 ... Q9Y9P9 12927540
    16360 1h2b:A (1.62) BS05 ZN 1.1.1.1 GO:0000166 ... Q9Y9P9 12927540
    16361 1h2b:B (1.62) BS01 OCA 1.1.1.1 GO:0000166 ... Q9Y9P9 12927540
    16362 1h2b:B (1.62) BS02 NAJ 1.1.1.1 GO:0000166 ... Q9Y9P9 12927540
    16363 1h2b:B (1.62) BS03 ZN 1.1.1.1 GO:0000166 ... Q9Y9P9 12927540
    16364 1h2b:B (1.62) BS04 ZN 1.1.1.1 GO:0000166 ... Q9Y9P9 12927540
    16365 1h2e:A (1.69) BS01 PO4 ? GO:0003824 ... Q9ALU0 12498792
    16366 1h2f:A (2.0) BS01 VA3 ? GO:0003824 ... Q9ALU0 12498792
    16367 1h2f:A (2.0) BS02 PO4 ? GO:0003824 ... Q9ALU0 12498792
    16368 1h2g:B (2.0) BS01 CA 3.5.1.11 GO:0016787 ... P06875 12511194
    16369 1h2h:A (2.6) BS01 NAD 1.4.1.21 GO:0009435 ... Q9X1X6 12496312
    16370 1h2j:A (1.15) BS01 DCB 3.2.1.4 GO:0000272 ... O85465 12595701
    16371 1h2k:A (2.15) BS01 peptide 1.14.11.30
    1.14.11.n4
    GO:0003714 ... Q9NWT6 12446723
    16372 1h2k:A (2.15) BS02 FE2 1.14.11.30
    1.14.11.n4
    GO:0003714 ... Q9NWT6 12446723
    16373 1h2l:A (2.25) BS01 peptide 1.14.11.30
    1.14.11.n4
    GO:0003714 ... Q9NWT6 12446723
    16374 1h2l:A (2.25) BS02 FE2 1.14.11.30
    1.14.11.n4
    GO:0003714 ... Q9NWT6 12446723
    16375 1h2l:A (2.25) BS03 AKG 1.14.11.30
    1.14.11.n4
    GO:0003714 ... Q9NWT6 12446723
    16376 1h2m:A (2.5) BS01 peptide 1.14.11.30
    1.14.11.n4
    GO:0003714 ... Q9NWT6 12446723
    16377 1h2m:A (2.5) BS02 ZN 1.14.11.30
    1.14.11.n4
    GO:0003714 ... Q9NWT6 12446723
    16378 1h2n:A (2.84) BS01 FE2 1.14.11.30
    1.14.11.n4
    GO:0003714 ... Q9NWT6 12446723
    16379 1h2n:A (2.84) BS02 AKG 1.14.11.30
    1.14.11.n4
    GO:0003714 ... Q9NWT6 12446723
    16380 1h2r:L (1.4) BS01 SF4 1.12.2.1 GO:0008901 ... P21852 10378274
    16381 1h2r:L (1.4) BS02 MG 1.12.2.1 GO:0008901 ... P21852 10378274
    16382 1h2r:L (1.4) BS03 NFE 1.12.2.1 GO:0008901 ... P21852 10378274
    16383 1h2r:S (1.4) BS01 SF4 1.12.2.1 GO:0008901 ... P21853 10378274
    16384 1h2r:S (1.4) BS02 SF4 1.12.2.1 GO:0008901 ... P21853 10378274
    16385 1h2r:S (1.4) BS03 F3S 1.12.2.1 GO:0008901 ... P21853 10378274
    16386 1h2s:A (1.93) BS01 RET ? GO:0005216 ... P42196 12368857
    16387 1h2t:Z (2.1) BS01 GDP ? GO:0000184 ... P52298 12374755 PDBbind: -logKd/Ki=7.89, Kd=13nM
    16388 1h2t:Z (2.1) BS02 7MG ? GO:0000184 ... P52298 12374755 PDBbind: -logKd/Ki=7.89, Kd=13nM
    16389 1h2u:X (2.4) BS01 GDP ? GO:0000184 ... P52298 12374755 PDBbind: -logKd/Ki=7.89, Kd=13nM
    16390 1h2u:X (2.4) BS02 7MG ? GO:0000184 ... P52298 12374755 PDBbind: -logKd/Ki=7.89, Kd=13nM
    16391 1h2u:Y (2.4) BS01 GDP ? GO:0000184 ... P52298 12374755
    16392 1h2u:Y (2.4) BS02 7MG ? GO:0000184 ... P52298 12374755
    16393 1h2y:A (1.78) BS01 ZPR 3.4.21.26 GO:0004252 ... P23687 12202494 BindingDB: IC50=0.33nM
    16394 1h2z:A (1.65) BS01 PRO 3.4.21.26 GO:0004252 ... P23687 12202494
    16395 1h31:A (2.55) BS01 HEC 2.8.5.2 GO:0004792 ... Q939U1 12411478
    16396 1h31:A (2.55) BS02 HEC 2.8.5.2 GO:0004792 ... Q939U1 12411478
    16397 1h31:B (2.55) BS01 HEC ? GO:0009055 ... Q939U4 12411478
    16398 1h31:C (2.55) BS01 HEC 2.8.5.2 GO:0004792 ... Q939U1 12411478
    16399 1h31:C (2.55) BS02 HEC 2.8.5.2 GO:0004792 ... Q939U1 12411478
    16400 1h31:D (2.55) BS01 HEC ? GO:0009055 ... Q939U4 12411478

    Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).
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