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BioLiP
Download all results in tab-seperated text for 817662 receptor-ligand interactions, whose format is explained at readme.txt.
  • Hover over PDB to view the title of the structure. Click PDB to view the structure at the RCSB PDB database. Resolution -1.00 means the resolution is unavailable, e.g., for NMR structures.
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  • Hover over EC number to view the full name of enzymatic activity.
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    # PDB
    (Resolution Å)
    Site # Ligand EC number GO terms UniProt PubMed Binding
    affinity
    33401 1njy:A (2.0) BS06 FRU 2.7.7.7 GO:0003676 ... P52026 15035983
    33402 1njy:A (2.0) BS07 TTP 2.7.7.7 GO:0003676 ... P52026 15035983
    33403 1njy:A (2.0) BS08 MG 2.7.7.7 GO:0003676 ... P52026 15035983
    33404 1njz:A (2.0) BS01 dna 2.7.7.7 GO:0003676 ... P52026 15035983
    33405 1njz:A (2.0) BS02 dna 2.7.7.7 GO:0003676 ... P52026 15035983
    33406 1njz:A (2.0) BS03 GLC 2.7.7.7 GO:0003676 ... P52026 15035983
    33407 1njz:A (2.0) BS04 FRU 2.7.7.7 GO:0003676 ... P52026 15035983
    33408 1njz:A (2.0) BS05 MG 2.7.7.7 GO:0003676 ... P52026 15035983
    33409 1nk0:A (1.7) BS01 dna 2.7.7.7 GO:0003676 ... P52026 15035983
    33410 1nk0:A (1.7) BS02 dna 2.7.7.7 GO:0003676 ... P52026 15035983
    33411 1nk0:A (1.7) BS03 GLC 2.7.7.7 GO:0003676 ... P52026 15035983
    33412 1nk0:A (1.7) BS04 FRU 2.7.7.7 GO:0003676 ... P52026 15035983
    33413 1nk2:P (-1.00) BS01 dna ? GO:0000981 ... P22808 9154919 PDBbind: Kd=0.19nM
    33414 1nk2:P (-1.00) BS02 dna ? GO:0000981 ... P22808 9154919 PDBbind: Kd=0.19nM
    33415 1nk3:P (-1.00) BS01 dna ? GO:0000981 ... P22808 9154919
    33416 1nk3:P (-1.00) BS02 dna ? GO:0000981 ... P22808 9154919
    33417 1nk4:A (1.6) BS01 dna 2.7.7.7 GO:0003676 ... P52026 15035983
    33418 1nk4:A (1.6) BS02 dna 2.7.7.7 GO:0003676 ... P52026 15035983
    33419 1nk4:A (1.6) BS03 FRU 2.7.7.7 GO:0003676 ... P52026 15035983
    33420 1nk4:A (1.6) BS04 MG 2.7.7.7 GO:0003676 ... P52026 15035983
    33421 1nk5:A (2.1) BS01 dna 2.7.7.7 GO:0003676 ... P52026 15035983
    33422 1nk5:A (2.1) BS02 dna 2.7.7.7 GO:0003676 ... P52026 15035983
    33423 1nk5:A (2.1) BS03 GLC 2.7.7.7 GO:0003676 ... P52026 15035983
    33424 1nk5:A (2.1) BS04 FRU 2.7.7.7 GO:0003676 ... P52026 15035983
    33425 1nk5:A (2.1) BS05 MG 2.7.7.7 GO:0003676 ... P52026 15035983
    33426 1nk6:A (2.1) BS01 dna 2.7.7.7 GO:0003676 ... P52026 15035983
    33427 1nk6:A (2.1) BS02 dna 2.7.7.7 GO:0003676 ... P52026 15035983
    33428 1nk6:A (2.1) BS03 GLC 2.7.7.7 GO:0003676 ... P52026 15035983
    33429 1nk6:A (2.1) BS04 FRU 2.7.7.7 GO:0003676 ... P52026 15035983
    33430 1nk6:A (2.1) BS05 GLC 2.7.7.7 GO:0003676 ... P52026 15035983
    33431 1nk7:A (1.9) BS01 dna 2.7.7.7 GO:0003676 ... P52026 15035983
    33432 1nk7:A (1.9) BS02 dna 2.7.7.7 GO:0003676 ... P52026 15035983
    33433 1nk7:A (1.9) BS03 GLC 2.7.7.7 GO:0003676 ... P52026 15035983
    33434 1nk7:A (1.9) BS04 FRU 2.7.7.7 GO:0003676 ... P52026 15035983
    33435 1nk7:A (1.9) BS05 GLC 2.7.7.7 GO:0003676 ... P52026 15035983
    33436 1nk7:A (1.9) BS06 MG 2.7.7.7 GO:0003676 ... P52026 15035983
    33437 1nk8:A (1.9) BS01 dna 2.7.7.7 GO:0003676 ... P52026 15035983
    33438 1nk8:A (1.9) BS02 dna 2.7.7.7 GO:0003676 ... P52026 15035983
    33439 1nk8:A (1.9) BS03 FRU 2.7.7.7 GO:0003676 ... P52026 15035983
    33440 1nk8:A (1.9) BS04 GLC 2.7.7.7 GO:0003676 ... P52026 15035983
    33441 1nk8:A (1.9) BS05 GLC 2.7.7.7 GO:0003676 ... P52026 15035983
    33442 1nk8:A (1.9) BS06 MG 2.7.7.7 GO:0003676 ... P52026 15035983
    33443 1nk9:A (1.9) BS01 dna 2.7.7.7 GO:0003676 ... P52026 15035983
    33444 1nk9:A (1.9) BS02 dna 2.7.7.7 GO:0003676 ... P52026 15035983
    33445 1nk9:A (1.9) BS03 GLC 2.7.7.7 GO:0003676 ... P52026 15035983
    33446 1nk9:A (1.9) BS04 FRU 2.7.7.7 GO:0003676 ... P52026 15035983
    33447 1nk9:A (1.9) BS05 GLC 2.7.7.7 GO:0003676 ... P52026 15035983
    33448 1nk9:A (1.9) BS06 MG 2.7.7.7 GO:0003676 ... P52026 15035983
    33449 1nkb:A (2.0) BS01 dna 2.7.7.7 GO:0003676 ... P52026 15035983
    33450 1nkb:A (2.0) BS02 dna 2.7.7.7 GO:0003676 ... P52026 15035983
    33451 1nkb:A (2.0) BS03 GLC 2.7.7.7 GO:0003676 ... P52026 15035983
    33452 1nkb:A (2.0) BS04 FRU 2.7.7.7 GO:0003676 ... P52026 15035983
    33453 1nkb:A (2.0) BS05 GLC 2.7.7.7 GO:0003676 ... P52026 15035983
    33454 1nkb:A (2.0) BS06 FRU 2.7.7.7 GO:0003676 ... P52026 15035983
    33455 1nkb:A (2.0) BS07 MG 2.7.7.7 GO:0003676 ... P52026 15035983
    33456 1nkc:A (1.8) BS01 dna 2.7.7.7 GO:0003676 ... P52026 15035983
    33457 1nkc:A (1.8) BS02 dna 2.7.7.7 GO:0003676 ... P52026 15035983
    33458 1nkc:A (1.8) BS03 GLC 2.7.7.7 GO:0003676 ... P52026 15035983
    33459 1nkc:A (1.8) BS04 FRU 2.7.7.7 GO:0003676 ... P52026 15035983
    33460 1nkc:A (1.8) BS05 MG 2.7.7.7 GO:0003676 ... P52026 15035983
    33461 1nke:A (1.8) BS01 dna 2.7.7.7 GO:0003676 ... P52026 15035983
    33462 1nke:A (1.8) BS02 dna 2.7.7.7 GO:0003676 ... P52026 15035983
    33463 1nke:A (1.8) BS03 GLC 2.7.7.7 GO:0003676 ... P52026 15035983
    33464 1nke:A (1.8) BS04 FRU 2.7.7.7 GO:0003676 ... P52026 15035983
    33465 1nke:A (1.8) BS05 GLC 2.7.7.7 GO:0003676 ... P52026 15035983
    33466 1nke:A (1.8) BS06 DCP 2.7.7.7 GO:0003676 ... P52026 15035983
    33467 1nke:A (1.8) BS07 MG 2.7.7.7 GO:0003676 ... P52026 15035983
    33468 1nkg:A (1.5) BS01 CA 4.2.2.23 GO:0000272 ... Q00019 15135077
    33469 1nkh:A (2.0) BS01 CA ? GO:0004461 ... P29752 11419947
    33470 1nkh:B (2.0) BS01 MN 2.4.1.-
    2.4.1.22
    2.4.1.275
    2.4.1.38
    2.4.1.90
    GO:0005975 ... P08037 11419947
    33471 1nkh:B (2.0) BS02 UDP 2.4.1.-
    2.4.1.22
    2.4.1.275
    2.4.1.38
    2.4.1.90
    GO:0005975 ... P08037 11419947
    33472 1nkh:B (2.0) BS03 UDP 2.4.1.-
    2.4.1.22
    2.4.1.275
    2.4.1.38
    2.4.1.90
    GO:0005975 ... P08037 11419947
    33473 1nkh:C (2.0) BS01 CA ? GO:0004461 ... P29752 11419947
    33474 1nkh:D (2.0) BS01 MN 2.4.1.-
    2.4.1.22
    2.4.1.275
    2.4.1.38
    2.4.1.90
    GO:0005975 ... P08037 11419947
    33475 1nkh:D (2.0) BS02 UDP 2.4.1.-
    2.4.1.22
    2.4.1.275
    2.4.1.38
    2.4.1.90
    GO:0005975 ... P08037 11419947
    33476 1nkh:D (2.0) BS03 UDP 2.4.1.-
    2.4.1.22
    2.4.1.275
    2.4.1.38
    2.4.1.90
    GO:0005975 ... P08037 11419947
    33477 1nki:A (0.95) BS01 MN 2.5.1.18 GO:0004364 ... Q9I4K6 15504029
    33478 1nki:A (0.95) BS02 PPF 2.5.1.18 GO:0004364 ... Q9I4K6 15504029 MOAD: Kd=0.2uM
    PDBbind: -logKd/Ki=6.70, Kd=0.2uM
    33479 1nki:B (0.95) BS01 MN 2.5.1.18 GO:0004364 ... Q9I4K6 15504029
    33480 1nki:B (0.95) BS02 PPF 2.5.1.18 GO:0004364 ... Q9I4K6 15504029 MOAD: Kd=0.2uM
    PDBbind: -logKd/Ki=6.70, Kd=0.2uM
    33481 1nkk:A (2.6) BS01 peptide 3.4.21.97 GO:0004252 ... P16753 12549906
    33482 1nkk:A (2.6) BS02 peptide 3.4.21.97 GO:0004252 ... P16753 12549906
    33483 1nkk:B (2.6) BS01 peptide 3.4.21.97 GO:0004252 ... P16753 12549906
    33484 1nkk:B (2.6) BS02 peptide 3.4.21.97 GO:0004252 ... P16753 12549906
    33485 1nkk:C (2.6) BS01 peptide 3.4.21.97 GO:0004252 ... P16753 12549906
    33486 1nkk:C (2.6) BS02 peptide 3.4.21.97 GO:0004252 ... P16753 12549906
    33487 1nkk:D (2.6) BS01 peptide 3.4.21.97 GO:0004252 ... P16753 12549906
    33488 1nkm:A (2.7) BS01 0FP 3.4.21.97 GO:0004252 ... P16753 12549906 PDBbind: -logKd/Ki=7.30, IC50<0.05uM
    33489 1nkp:A (1.8) BS01 dna ? GO:0003700 ... P01106 12553908 PDBbind: Kd=90nM
    33490 1nkp:A (1.8) BS02 dna ? GO:0003700 ... P01106 12553908 PDBbind: Kd=90nM
    33491 1nkp:B (1.8) BS01 dna ? GO:0046983 ... P61244 12553908 PDBbind: Kd=90nM
    33492 1nkp:B (1.8) BS02 dna ? GO:0046983 ... P61244 12553908 PDBbind: Kd=90nM
    33493 1nkp:D (1.8) BS01 dna ? GO:0003700 ... P01106 12553908 PDBbind: Kd=90nM
    33494 1nkp:D (1.8) BS02 dna ? GO:0003700 ... P01106 12553908 PDBbind: Kd=90nM
    33495 1nkp:E (1.8) BS01 dna ? GO:0046983 ... P61244 12553908 PDBbind: Kd=90nM
    33496 1nkp:E (1.8) BS02 dna ? GO:0046983 ... P61244 12553908 PDBbind: Kd=90nM
    33497 1nkq:A (2.2) BS01 CA 3.-.-.- GO:0003674 ... P53889 N/A
    33498 1nkq:B (2.2) BS01 CA 3.-.-.- GO:0003674 ... P53889 N/A
    33499 1nkq:C (2.2) BS01 CA 3.-.-.- GO:0003674 ... P53889 N/A
    33500 1nkq:D (2.2) BS01 CA 3.-.-.- GO:0003674 ... P53889 N/A
    33501 1nkq:E (2.2) BS01 CA 3.-.-.- GO:0003674 ... P53889 N/A
    33502 1nkq:F (2.2) BS01 CA 3.-.-.- GO:0003674 ... P53889 N/A
    33503 1nks:C (2.57) BS01 AMP 2.7.4.3 GO:0004017 ... P35028 9733648
    33504 1nks:D (2.57) BS01 AMP 2.7.4.3 GO:0004017 ... P35028 9733648
    33505 1nks:F (2.57) BS01 AMP 2.7.4.3 GO:0004017 ... P35028 9733648
    33506 1nks:F (2.57) BS02 ADP 2.7.4.3 GO:0004017 ... P35028 9733648
    33507 1nkt:A (2.601) BS01 ADP 7.4.2.8 GO:0005515 ... P9WGP5 12606717
    33508 1nkt:B (2.601) BS01 ADP 7.4.2.8 GO:0005515 ... P9WGP5 12606717
    33509 1nku:A (-1.00) BS01 ZN 3.2.2.20 GO:0003824 ... P05100 12654914
    33510 1nkw:3 (3.1) BS01 rna ? GO:0003735 ... Q9RSW6 11733066
    33511 1nkw:A (3.1) BS01 rna ? GO:0002181 ... Q9RXJ9 11733066
    33512 1nkw:B (3.1) BS01 rna ? GO:0003735 ... Q9RXK2 11733066
    33513 1nkw:C (3.1) BS01 rna ? GO:0003735 ... Q9RXK1 11733066
    33514 1nkw:D (3.1) BS01 rna ? GO:0000049 ... Q9RXJ0 11733066
    33515 1nkw:I (3.1) BS01 rna ? GO:0003735 ... Q9RXJ2 11733066
    33516 1nkw:J (3.1) BS01 rna ? GO:0003735 ... Q9RSK9 11733066
    33517 1nkw:K (3.1) BS01 rna ? GO:0000049 ... Q9RXJ5 11733066
    33518 1nkw:L (3.1) BS01 rna ? GO:0003735 ... Q9RSJ5 11733066
    33519 1nkw:O (3.1) BS01 rna ? GO:0000027 ... Q9RSW7 11733066
    33520 1nkw:Q (3.1) BS01 rna ? GO:0003735 ... Q9RXJ7 11733066
    33521 1nkw:X (3.1) BS01 rna ? GO:0003735 ... Q9RSL0 11733066
    33522 1nkw:Y (3.1) BS01 rna ? GO:0000049 ... Q9RW44 11733066
    33523 1nkw:Z (3.1) BS01 rna ? GO:0003735 ... P49228 11733066
    33524 1nkx:A (1.9) BS01 FE 3.4.21.- GO:0005576 ... P24627 12888354
    33525 1nkx:A (1.9) BS02 CO3 3.4.21.- GO:0005576 ... P24627 12888354
    33526 1nkz:A (2.0) BS01 BCL ? GO:0005886 ... P26789 12595263
    33527 1nkz:A (2.0) BS02 BCL ? GO:0005886 ... P26789 12595263
    33528 1nkz:A (2.0) BS03 BCL ? GO:0005886 ... P26789 12595263
    33529 1nkz:B (2.0) BS01 BCL ? GO:0005886 ... P26790 12595263
    33530 1nkz:B (2.0) BS02 BCL ? GO:0005886 ... P26790 12595263
    33531 1nkz:B (2.0) BS03 BCL ? GO:0005886 ... P26790 12595263
    33532 1nkz:C (2.0) BS01 BCL ? GO:0005886 ... P26789 12595263
    33533 1nkz:C (2.0) BS02 BCL ? GO:0005886 ... P26789 12595263
    33534 1nkz:C (2.0) BS03 BCL ? GO:0005886 ... P26789 12595263
    33535 1nkz:C (2.0) BS04 BCL ? GO:0005886 ... P26789 12595263
    33536 1nkz:D (2.0) BS01 BCL ? GO:0005886 ... P26790 12595263
    33537 1nkz:D (2.0) BS02 BCL ? GO:0005886 ... P26790 12595263
    33538 1nkz:D (2.0) BS03 BCL ? GO:0005886 ... P26790 12595263
    33539 1nkz:E (2.0) BS01 BCL ? GO:0005886 ... P26789 12595263
    33540 1nkz:E (2.0) BS02 BCL ? GO:0005886 ... P26789 12595263
    33541 1nkz:E (2.0) BS03 BCL ? GO:0005886 ... P26789 12595263
    33542 1nkz:E (2.0) BS04 BCL ? GO:0005886 ... P26789 12595263
    33543 1nkz:F (2.0) BS01 BCL ? GO:0005886 ... P26790 12595263
    33544 1nkz:F (2.0) BS02 BCL ? GO:0005886 ... P26790 12595263
    33545 1nkz:F (2.0) BS03 BCL ? GO:0005886 ... P26790 12595263
    33546 1nl0:G (2.2) BS01 CA 3.4.21.22 GO:0005509 ... P00740 14722079
    33547 1nl0:G (2.2) BS02 CA 3.4.21.22 GO:0005509 ... P00740 14722079
    33548 1nl0:G (2.2) BS03 CA 3.4.21.22 GO:0005509 ... P00740 14722079
    33549 1nl0:G (2.2) BS04 CA 3.4.21.22 GO:0005509 ... P00740 14722079
    33550 1nl0:G (2.2) BS05 CA 3.4.21.22 GO:0005509 ... P00740 14722079
    33551 1nl0:G (2.2) BS06 CA 3.4.21.22 GO:0005509 ... P00740 14722079
    33552 1nl1:A (1.9) BS01 CA 3.4.21.5 GO:0005509 ... P00735 12923575
    33553 1nl1:A (1.9) BS02 CA 3.4.21.5 GO:0005509 ... P00735 12923575
    33554 1nl1:A (1.9) BS03 CA 3.4.21.5 GO:0005509 ... P00735 12923575
    33555 1nl1:A (1.9) BS04 CA 3.4.21.5 GO:0005509 ... P00735 12923575
    33556 1nl1:A (1.9) BS05 CA 3.4.21.5 GO:0005509 ... P00735 12923575
    33557 1nl1:A (1.9) BS06 CA 3.4.21.5 GO:0005509 ... P00735 12923575
    33558 1nl2:A (2.3) BS01 CA 3.4.21.5 GO:0005509 ... P00735 12923575
    33559 1nl2:A (2.3) BS02 CA 3.4.21.5 GO:0005509 ... P00735 12923575
    33560 1nl2:A (2.3) BS03 CA 3.4.21.5 GO:0005509 ... P00735 12923575
    33561 1nl2:A (2.3) BS04 CA 3.4.21.5 GO:0005509 ... P00735 12923575
    33562 1nl2:A (2.3) BS05 CA 3.4.21.5 GO:0005509 ... P00735 12923575
    33563 1nl2:A (2.3) BS06 CA 3.4.21.5 GO:0005509 ... P00735 12923575
    33564 1nl2:A (2.3) BS07 LPS 3.4.21.5 GO:0005509 ... P00735 12923575
    33565 1nl4:B (2.7) BS01 ZN 2.5.1.58 GO:0003824 ... Q02293 12657284
    33566 1nl4:B (2.7) BS02 HFP 2.5.1.58 GO:0003824 ... Q02293 12657284
    33567 1nl4:B (2.7) BS03 FTL 2.5.1.58 GO:0003824 ... Q02293 12657284 PDBbind: -logKd/Ki=9.41, IC50=0.39nM
    33568 1nl5:A (2.1) BS01 GLC ? GO:0005515 ... P0AEX9 12794084
    33569 1nl5:A (2.1) BS02 GLC ? GO:0005515 ... P0AEX9 12794084
    33570 1nl6:A (2.8) BS01 750 3.4.22.38 GO:0006508 ... P43235 11311061 PDBbind: -logKd/Ki=11.32, Ki=4.8pM
    BindingDB: IC50=30nM, Ki=0.0048nM
    33571 1nl6:B (2.8) BS01 750 3.4.22.38 GO:0006508 ... P43235 11311061 BindingDB: IC50=30nM, Ki=0.0048nM
    33572 1nl7:A (1.903) BS01 COA 2.3.1.9 GO:0003985 ... P07097 N/A
    33573 1nl7:B (1.903) BS01 COA 2.3.1.9 GO:0003985 ... P07097 N/A
    33574 1nl9:A (2.4) BS01 989 3.1.3.48 GO:0004725 ... P18031 12670229 PDBbind: -logKd/Ki=5.96, Ki=1.1uM
    BindingDB: Ki=631nM
    33575 1nlf:B (1.95) BS01 SO4 ? GO:0005524 ... P20356 12777796
    33576 1nli:A (1.93) BS01 ADE 3.2.2.22 GO:0006952 ... P09989 12676436 MOAD: Kd=260uM
    PDBbind: -logKd/Ki=3.59, Kd=260uM
    33577 1nlj:A (2.4) BS01 2CA 3.4.22.38 GO:0006508 ... P43235 11311061 PDBbind: -logKd/Ki=9.80, Ki=0.16nM
    BindingDB: Ki=0.16nM, IC50=70nM
    33578 1nlj:B (2.4) BS01 2CA 3.4.22.38 GO:0006508 ... P43235 11311061 BindingDB: Ki=0.16nM, IC50=70nM
    33579 1nlk:L (2.0) BS01 ADP 2.7.4.6 GO:0004550 ... P15266 8263923
    33580 1nlk:R (2.0) BS01 ADP 2.7.4.6 GO:0004550 ... P15266 8263923
    33581 1nlm:A (2.5) BS01 UD1 2.4.1.227 GO:0005515 ... P17443 12538870
    33582 1nlm:B (2.5) BS01 UD1 2.4.1.227 GO:0005515 ... P17443 12538870
    33583 1nln:A (1.6) BS01 peptide 3.4.22.39 GO:0003677 ... P03252 12758141
    33584 1nlo:C (-1.00) BS01 peptide 2.7.10.2 GO:0006897 ... P00523 8807900
    33585 1nlp:C (-1.00) BS01 peptide 2.7.10.2 GO:0006897 ... P00523 8807900
    33586 1nls:A (0.94) BS01 MN ? GO:0030246 ... P02866 N/A
    33587 1nls:A (0.94) BS02 CA ? GO:0030246 ... P02866 N/A
    33588 1nlt:A (2.7) BS01 peptide ? GO:0006457 ... P25491 14656432
    33589 1nlt:A (2.7) BS02 ZN ? GO:0006457 ... P25491 14656432
    33590 1nlt:A (2.7) BS03 ZN ? GO:0006457 ... P25491 14656432
    33591 1nlu:A (1.3) BS01 peptide 3.4.21.100 GO:0004252 ... P42790 14733955
    33592 1nlu:A (1.3) BS02 peptide 3.4.21.100 GO:0004252 ... P42790 14733955
    33593 1nlu:A (1.3) BS03 CA 3.4.21.100 GO:0004252 ... P42790 14733955
    33594 1nlv:A (1.8) BS01 ATP 3.6.4.- GO:0000281 ... P07830 12732734
    33595 1nlv:G (1.8) BS01 CA ? GO:0051015 ... P06396 12732734
    33596 1nlw:A (2.0) BS01 dna ? GO:0000122 ... Q05195 12553908
    33597 1nlw:A (2.0) BS02 dna ? GO:0000122 ... Q05195 12553908
    33598 1nlw:B (2.0) BS01 dna ? GO:0046983 ... P61244 12553908
    33599 1nlw:B (2.0) BS02 dna ? GO:0046983 ... P61244 12553908
    33600 1nlw:D (2.0) BS01 dna ? GO:0000122 ... Q05195 12553908

    Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).
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