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BioLiP
Download all results in tab-seperated text for 832530 receptor-ligand interactions, whose format is explained at readme.txt.
  • Hover over PDB to view the title of the structure. Click PDB to view the structure at the RCSB PDB database. Resolution -1.00 means the resolution is unavailable, e.g., for NMR structures.
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  • Hover over Ligand to view the full ligand name. Click Ligand to view the 2D diagram and other detail information of the ligand.
  • Hover over EC number to view the full name of enzymatic activity.
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    # PDB
    (Resolution Å)
    Site # Ligand EC number GO terms UniProt PubMed Binding
    affinity
    13201 1ftk:A (1.6) BS01 KAI ? GO:0015276 ... P19491 11086992 MOAD: ic50=14.5uM
    PDBbind: -logKd/Ki=4.84, IC50=14.5uM
    BindingDB: EC50=380000nM, Ki=3690nM
    13202 1ftl:A (1.8) BS01 DNQ ? GO:0015276 ... P19491 11086992 MOAD: ic50=998nM
    13203 1ftl:B (1.8) BS01 DNQ ? GO:0015276 ... P19491 11086992 MOAD: ic50=998nM
    13204 1ftm:A (1.7) BS01 ZN ? GO:0015276 ... P19491 11086992
    13205 1ftm:A (1.7) BS02 AMQ ? GO:0015276 ... P19491 11086992 MOAD: Kd=24.8nM
    PDBbind: -logKd/Ki=7.61, Kd=24.8nM
    BindingDB: Ki=17nM
    13206 1ftm:B (1.7) BS01 ZN ? GO:0015276 ... P19491 11086992
    13207 1ftm:B (1.7) BS02 ZN ? GO:0015276 ... P19491 11086992
    13208 1ftm:B (1.7) BS03 AMQ ? GO:0015276 ... P19491 11086992 MOAD: Kd=24.8nM
    BindingDB: Ki=17nM
    13209 1ftm:C (1.7) BS01 ZN ? GO:0015276 ... P19491 11086992
    13210 1ftm:C (1.7) BS02 AMQ ? GO:0015276 ... P19491 11086992 MOAD: Kd=24.8nM
    BindingDB: Ki=17nM
    13211 1ftn:A (2.1) BS01 MG 3.6.5.2 GO:0000902 ... P61586 9302995
    13212 1ftn:A (2.1) BS02 GDP 3.6.5.2 GO:0000902 ... P61586 9302995
    13213 1ftq:A (2.35) BS01 GL2 2.4.1.1 GO:0000166 ... P00489 16222658
    13214 1ftq:A (2.35) BS02 PLP 2.4.1.1 GO:0000166 ... P00489 16222658
    13215 1ftq:A (2.35) BS03 IMP 2.4.1.1 GO:0000166 ... P00489 16222658
    13216 1ftw:A (2.36) BS01 GL5 2.4.1.1 GO:0000166 ... P00489 16222658
    13217 1ftw:A (2.36) BS02 PLP 2.4.1.1 GO:0000166 ... P00489 16222658
    13218 1ftx:A (2.2) BS01 EPC 5.1.1.1 GO:0003824 ... P10724 N/A
    13219 1ftx:A (2.2) BS02 EPC 5.1.1.1 GO:0003824 ... P10724 N/A
    13220 1ftx:B (2.2) BS01 EPC 5.1.1.1 GO:0003824 ... P10724 N/A
    13221 1ftx:B (2.2) BS02 EPC 5.1.1.1 GO:0003824 ... P10724 N/A
    13222 1fty:A (2.38) BS01 GL7 2.4.1.1 GO:0000166 ... P00489 16222658
    13223 1fty:A (2.38) BS02 PLP 2.4.1.1 GO:0000166 ... P00489 16222658
    13224 1fu2:B (-1.00) BS01 peptide ? GO:0005179 ... P01308 11092920
    13225 1fu2:D (-1.00) BS01 peptide ? GO:0005179 ... P01308 11092920
    13226 1fu2:F (-1.00) BS01 peptide ? GO:0005179 ... P01308 11092920
    13227 1fu2:H (-1.00) BS01 peptide ? GO:0005179 ... P01308 11092920
    13228 1fu4:A (2.36) BS01 GL9 2.4.1.1 GO:0000166 ... P00489 16222658
    13229 1fu4:A (2.36) BS02 PLP 2.4.1.1 GO:0000166 ... P00489 16222658
    13230 1fu5:A (-1.00) BS01 peptide ? N/A Q63787 11123912
    13231 1fu7:A (2.36) BS01 CR1 2.4.1.1 GO:0000166 ... P00489 16222658 BindingDB: Ki=210000nM
    13232 1fu7:A (2.36) BS02 PLP 2.4.1.1 GO:0000166 ... P00489 16222658
    13233 1fu8:A (2.35) BS01 CR6 2.4.1.1 GO:0000166 ... P00489 16222658 BindingDB: Ki=310000nM
    13234 1fu8:A (2.35) BS02 PLP 2.4.1.1 GO:0000166 ... P00489 16222658
    13235 1fu9:A (-1.00) BS01 ZN ? GO:0006357 ... Q9VPQ6 11080638
    13236 1fua:A (1.92) BS01 ZN 4.1.2.17 GO:0005829 ... P0AB87 15299567
    13237 1fub:B (-1.00) BS01 peptide ? GO:0005179 ... P01308 11092920
    13238 1fub:D (-1.00) BS01 peptide ? GO:0005179 ... P01308 11092920
    13239 1fue:A (2.4) BS01 FMN ? GO:0010181 ... Q9ZK53 11790835
    13240 1fui:A (2.5) BS01 MN 5.3.1.25
    5.3.1.3
    GO:0005737 ... P69922 9367760
    13241 1fui:A (2.5) BS02 FOC 5.3.1.25
    5.3.1.3
    GO:0005737 ... P69922 9367760
    13242 1fui:B (2.5) BS01 MN 5.3.1.25
    5.3.1.3
    GO:0005737 ... P69922 9367760
    13243 1fui:B (2.5) BS02 FOC 5.3.1.25
    5.3.1.3
    GO:0005737 ... P69922 9367760
    13244 1fui:C (2.5) BS01 MN 5.3.1.25
    5.3.1.3
    GO:0005737 ... P69922 9367760
    13245 1fui:C (2.5) BS02 FOC 5.3.1.25
    5.3.1.3
    GO:0005737 ... P69922 9367760
    13246 1fui:D (2.5) BS01 MN 5.3.1.25
    5.3.1.3
    GO:0005737 ... P69922 9367760
    13247 1fui:D (2.5) BS02 FOC 5.3.1.25
    5.3.1.3
    GO:0005737 ... P69922 9367760
    13248 1fui:E (2.5) BS01 MN 5.3.1.25
    5.3.1.3
    GO:0005737 ... P69922 9367760
    13249 1fui:E (2.5) BS02 FOC 5.3.1.25
    5.3.1.3
    GO:0005737 ... P69922 9367760
    13250 1fui:F (2.5) BS01 FOC 5.3.1.25
    5.3.1.3
    GO:0005737 ... P69922 9367760
    13251 1fuj:A (2.2) BS01 NAG 3.4.21.76 GO:0004252 ... P24158 8757293
    13252 1fuj:A (2.2) BS02 FUC 3.4.21.76 GO:0004252 ... P24158 8757293
    13253 1fuj:B (2.2) BS01 FUC 3.4.21.76 GO:0004252 ... P24158 8757293
    13254 1fuj:C (2.2) BS01 FUC 3.4.21.76 GO:0004252 ... P24158 8757293
    13255 1fuj:D (2.2) BS01 FUC 3.4.21.76 GO:0004252 ... P24158 8757293
    13256 1fuk:A (1.75) BS01 ZN 3.6.4.13 N/A P10081 11087862
    13257 1fun:A (2.85) BS01 CU 1.15.1.1 GO:0000302 ... P00441 9294870
    13258 1fun:A (2.85) BS02 ZN 1.15.1.1 GO:0000302 ... P00441 9294870
    13259 1fun:B (2.85) BS01 CU 1.15.1.1 GO:0000302 ... P00441 9294870
    13260 1fun:B (2.85) BS02 ZN 1.15.1.1 GO:0000302 ... P00441 9294870
    13261 1fun:C (2.85) BS01 CU 1.15.1.1 GO:0000302 ... P00441 9294870
    13262 1fun:C (2.85) BS02 ZN 1.15.1.1 GO:0000302 ... P00441 9294870
    13263 1fun:D (2.85) BS01 CU 1.15.1.1 GO:0000302 ... P00441 9294870
    13264 1fun:D (2.85) BS02 ZN 1.15.1.1 GO:0000302 ... P00441 9294870
    13265 1fun:E (2.85) BS01 CU 1.15.1.1 GO:0000302 ... P00441 9294870
    13266 1fun:E (2.85) BS02 ZN 1.15.1.1 GO:0000302 ... P00441 9294870
    13267 1fun:F (2.85) BS01 CU 1.15.1.1 GO:0000302 ... P00441 9294870
    13268 1fun:F (2.85) BS02 ZN 1.15.1.1 GO:0000302 ... P00441 9294870
    13269 1fun:G (2.85) BS01 CU 1.15.1.1 GO:0000302 ... P00441 9294870
    13270 1fun:G (2.85) BS02 ZN 1.15.1.1 GO:0000302 ... P00441 9294870
    13271 1fun:H (2.85) BS01 CU 1.15.1.1 GO:0000302 ... P00441 9294870
    13272 1fun:H (2.85) BS02 ZN 1.15.1.1 GO:0000302 ... P00441 9294870
    13273 1fun:I (2.85) BS01 CU 1.15.1.1 GO:0000302 ... P00441 9294870
    13274 1fun:I (2.85) BS02 ZN 1.15.1.1 GO:0000302 ... P00441 9294870
    13275 1fun:J (2.85) BS01 CU 1.15.1.1 GO:0000302 ... P00441 9294870
    13276 1fun:J (2.85) BS02 ZN 1.15.1.1 GO:0000302 ... P00441 9294870
    13277 1fuo:A (1.98) BS01 CIT 4.2.1.2 GO:0003824 ... P05042 8909293
    13278 1fuo:B (1.98) BS01 CIT 4.2.1.2 GO:0003824 ... P05042 8909293
    13279 1fup:A (2.3) BS01 PMA 4.2.1.2 GO:0003824 ... P05042 8909293
    13280 1fup:B (2.3) BS01 PMA 4.2.1.2 GO:0003824 ... P05042 8909293
    13281 1fuq:A (2.0) BS01 SIF 4.2.1.2 GO:0003824 ... P05042 8909293
    13282 1fuq:A (2.0) BS02 CIT 4.2.1.2 GO:0003824 ... P05042 8909293
    13283 1fuq:B (2.0) BS01 SIF 4.2.1.2 GO:0003824 ... P05042 8909293
    13284 1fuq:B (2.0) BS02 CIT 4.2.1.2 GO:0003824 ... P05042 8909293
    13285 1fut:A (2.0) BS01 2GP 4.6.1.24 GO:0003723 ... P10282 8386773
    13286 1fuy:A (2.25) BS01 FIP 4.2.1.20 GO:0000162 ... P00929 11034989
    13287 1fuy:B (2.25) BS01 PLP 4.2.1.20 GO:0000162 ... P0A2K1 11034989
    13288 1fv0:A (1.7) BS01 9AR 3.1.1.4 GO:0004623 ... P59071 12206661 MOAD: Ki=1.18uM
    PDBbind: -logKd/Ki=5.93, Ki=1.18uM
    13289 1fv1:A (1.9) BS01 peptide ? GO:0006955 ... P01903 11080454
    13290 1fv1:B (1.9) BS01 peptide ? GO:0006955 ... Q30154 11080454
    13291 1fv1:D (1.9) BS01 peptide ? GO:0006955 ... P01903 11080454
    13292 1fv1:E (1.9) BS01 peptide ? GO:0006955 ... Q30154 11080454
    13293 1fv2:A (2.5) BS01 GAL 3.4.24.68 GO:0005576 ... P04958 11418600
    13294 1fv3:A (2.3) BS01 GAL 3.4.24.68 GO:0005576 ... P04958 11418600
    13295 1fv3:B (2.3) BS01 GAL 3.4.24.68 GO:0005576 ... P04958 11418600
    13296 1fv5:A (-1.00) BS01 ZN ? GO:0006357 ... Q9VPQ6 11080638
    13297 1fv9:A (3.0) BS01 172 3.4.21.73 GO:0004252 ... P00749 11052791 PDBbind: -logKd/Ki=5.00, IC50=10uM
    13298 1fvi:A (2.0) BS01 AMP 6.5.1.- GO:0000166 ... A7RCB1 11106756
    13299 1fvo:A (2.6) BS01 CP 2.1.3.3 GO:0000050 ... P00480 11237854
    13300 1fvo:B (2.6) BS01 CP 2.1.3.3 GO:0000050 ... P00480 11237854
    13301 1fvp:A (2.7) BS01 FMA ? GO:0016705 ... P12745 15299728
    13302 1fvp:A (2.7) BS02 FMA ? GO:0016705 ... P12745 15299728
    13303 1fvp:A (2.7) BS03 FMA ? GO:0016705 ... P12745 15299728
    13304 1fvp:B (2.7) BS01 FMA ? GO:0016705 ... P12745 15299728
    13305 1fvp:B (2.7) BS02 FMA ? GO:0016705 ... P12745 15299728
    13306 1fvp:B (2.7) BS03 FMA ? GO:0016705 ... P12745 15299728
    13307 1fvs:A (-1.00) BS01 CU 7.2.2.8 GO:0046872 ... P38995 11083871
    13308 1fvt:A (2.2) BS01 106 2.7.11.22 GO:0000082 ... P24941 11141566 PDBbind: -logKd/Ki=7.22, IC50=60nM
    BindingDB: IC50=60nM
    13309 1fvu:B (1.8) BS01 MG ? GO:0005576 ... P22030 11148028
    13310 1fvu:D (1.8) BS01 MG ? GO:0005576 ... P22030 11148028
    13311 1fvv:A (2.8) BS01 107 2.7.11.22 GO:0000082 ... P24941 11141566 PDBbind: -logKd/Ki=8.00, IC50=10nM
    13312 1fvv:C (2.8) BS01 107 2.7.11.22 GO:0000082 ... P24941 11141566
    13313 1fvx:A (1.9) BS01 FMN ? GO:0009055 ... P00322 9063874
    13314 1fw0:A (1.9) BS01 KAI ? GO:0015276 ... P19491 11086992 PDBbind: -logKd/Ki=5.43, Ki=3690nM
    BindingDB: EC50=380000nM, Ki=3690nM
    13315 1fw1:A (1.9) BS01 SO4 2.5.1.18
    5.2.1.2
    GO:0003824 ... O43708 11327815
    13316 1fw1:A (1.9) BS02 GSH 2.5.1.18
    5.2.1.2
    GO:0003824 ... O43708 11327815
    13317 1fw2:A (2.6) BS01 CA 3.1.1.32
    3.1.1.4
    GO:0004620 ... P0A921 11371166
    13318 1fw4:A (1.7) BS01 CA ? GO:0005509 ... P62157 11320306
    13319 1fw4:A (1.7) BS02 CA ? GO:0005509 ... P62157 11320306
    13320 1fw6:A (2.7) BS01 dna ? GO:0003677 ... Q56215 11172706
    13321 1fw6:A (2.7) BS02 dna ? GO:0003677 ... Q56215 11172706
    13322 1fw6:A (2.7) BS03 ADP ? GO:0003677 ... Q56215 11172706
    13323 1fw6:B (2.7) BS01 dna ? GO:0003677 ... Q56215 11172706
    13324 1fw6:B (2.7) BS02 dna ? GO:0003677 ... Q56215 11172706
    13325 1fw6:B (2.7) BS03 ADP ? GO:0003677 ... Q56215 11172706
    13326 1fwa:C (2.0) BS01 NI 3.5.1.5 GO:0005515 ... P18314 9201965
    13327 1fwa:C (2.0) BS02 NI 3.5.1.5 GO:0005515 ... P18314 9201965
    13328 1fwa:C (2.0) BS03 CO3 3.5.1.5 GO:0005515 ... P18314 9201965
    13329 1fwb:C (2.0) BS01 NI 3.5.1.5 GO:0005515 ... P18314 9201965
    13330 1fwb:C (2.0) BS02 NI 3.5.1.5 GO:0005515 ... P18314 9201965
    13331 1fwc:C (2.0) BS01 NI 3.5.1.5 GO:0005515 ... P18314 9201965
    13332 1fwc:C (2.0) BS02 NI 3.5.1.5 GO:0005515 ... P18314 9201965
    13333 1fwd:C (2.0) BS01 NI 3.5.1.5 GO:0005515 ... P18314 9201965
    13334 1fwd:C (2.0) BS02 NI 3.5.1.5 GO:0005515 ... P18314 9201965
    13335 1fwe:C (2.0) BS01 NI 3.5.1.5 GO:0005515 ... P18314 9201965
    13336 1fwe:C (2.0) BS02 NI 3.5.1.5 GO:0005515 ... P18314 9201965
    13337 1fwe:C (2.0) BS03 HAE 3.5.1.5 GO:0005515 ... P18314 9201965 PDBbind: -logKd/Ki=5.60, Ki=2.5uM
    13338 1fwf:C (2.0) BS01 NI 3.5.1.5 GO:0005515 ... P18314 9201965
    13339 1fwf:C (2.0) BS02 NI 3.5.1.5 GO:0005515 ... P18314 9201965
    13340 1fwg:C (2.0) BS01 NI 3.5.1.5 GO:0005515 ... P18314 9201965
    13341 1fwg:C (2.0) BS02 NI 3.5.1.5 GO:0005515 ... P18314 9201965
    13342 1fwh:C (2.0) BS01 NI 3.5.1.5 GO:0005515 ... P18314 9201965
    13343 1fwh:C (2.0) BS02 NI 3.5.1.5 GO:0005515 ... P18314 9201965
    13344 1fwi:C (2.0) BS01 NI 3.5.1.5 GO:0005515 ... P18314 8702515
    13345 1fwj:C (2.2) BS01 NI 3.5.1.5 GO:0005515 ... P18314 9201965
    13346 1fwj:C (2.2) BS02 NI 3.5.1.5 GO:0005515 ... P18314 9201965
    13347 1fwk:A (2.1) BS01 ADP 2.7.1.39 GO:0004413 ... Q58504 11188689
    13348 1fwk:B (2.1) BS01 ADP 2.7.1.39 GO:0004413 ... Q58504 11188689
    13349 1fwk:C (2.1) BS01 ADP 2.7.1.39 GO:0004413 ... Q58504 11188689
    13350 1fwk:D (2.1) BS01 ADP 2.7.1.39 GO:0004413 ... Q58504 11188689
    13351 1fwm:A (2.2) BS01 SO4 2.1.1.45 GO:0000287 ... P0A884 16615077
    13352 1fwm:B (2.2) BS01 SO4 2.1.1.45 GO:0000287 ... P0A884 16615077
    13353 1fwn:A (1.94) BS01 PEP 2.5.1.55 GO:0005737 ... O66496 11115499
    13354 1fwn:B (1.94) BS01 PEP 2.5.1.55 GO:0005737 ... O66496 11115499
    13355 1fwq:A (-1.00) BS01 ZN ? GO:0005085 ... P47224 7651540
    13356 1fws:A (1.9) BS01 PEP 2.5.1.55 GO:0005737 ... O66496 19228070
    13357 1fws:B (1.9) BS01 PEP 2.5.1.55 GO:0005737 ... O66496 19228070
    13358 1fwt:A (1.9) BS01 PEP 2.5.1.55 GO:0005737 ... O66496 11115499
    13359 1fwt:A (1.9) BS02 E4P 2.5.1.55 GO:0005737 ... O66496 11115499
    13360 1fwt:B (1.9) BS01 PEP 2.5.1.55 GO:0005737 ... O66496 11115499
    13361 1fwu:A (1.9) BS01 SGA ? N/A Q61830 11152606 PDBbind: -logKd/Ki=3.70, Kd=0.20mM
    13362 1fwv:A (2.2) BS01 SGA ? N/A Q61830 11152606 PDBbind: -logKd/Ki=3.72, Kd=0.19mM
    13363 1fww:A (1.85) BS01 PEP 2.5.1.55 GO:0005737 ... O66496 19228070
    13364 1fww:A (1.85) BS02 A5P 2.5.1.55 GO:0005737 ... O66496 19228070
    13365 1fww:B (1.85) BS01 PEP 2.5.1.55 GO:0005737 ... O66496 19228070
    13366 1fwx:A (1.6) BS01 CA 1.7.2.4 GO:0004129 ... Q51705 11024061
    13367 1fwx:A (1.6) BS02 CA 1.7.2.4 GO:0004129 ... Q51705 11024061
    13368 1fwx:A (1.6) BS03 CUA 1.7.2.4 GO:0004129 ... Q51705 11024061
    13369 1fwx:B (1.6) BS01 CA 1.7.2.4 GO:0004129 ... Q51705 11024061
    13370 1fwx:B (1.6) BS02 CA 1.7.2.4 GO:0004129 ... Q51705 11024061
    13371 1fwx:B (1.6) BS03 CUA 1.7.2.4 GO:0004129 ... Q51705 11024061
    13372 1fwx:C (1.6) BS01 CA 1.7.2.4 GO:0004129 ... Q51705 11024061
    13373 1fwx:C (1.6) BS02 CA 1.7.2.4 GO:0004129 ... Q51705 11024061
    13374 1fwx:C (1.6) BS03 CA 1.7.2.4 GO:0004129 ... Q51705 11024061
    13375 1fwx:C (1.6) BS04 CUA 1.7.2.4 GO:0004129 ... Q51705 11024061
    13376 1fwx:D (1.6) BS01 CA 1.7.2.4 GO:0004129 ... Q51705 11024061
    13377 1fwx:D (1.6) BS02 CA 1.7.2.4 GO:0004129 ... Q51705 11024061
    13378 1fwx:D (1.6) BS03 CUA 1.7.2.4 GO:0004129 ... Q51705 11024061
    13379 1fwy:A (2.3) BS01 UD1 2.3.1.157
    2.7.7.23
    GO:0000287 ... P0ACC7 10428949
    13380 1fwy:B (2.3) BS01 UD1 2.3.1.157
    2.7.7.23
    GO:0000287 ... P0ACC7 10428949
    13381 1fwz:A (2.3) BS01 SO4 ? GO:0003677 ... P0DJL7 11320302
    13382 1fwz:A (2.3) BS02 ZN ? GO:0003677 ... P0DJL7 11320302
    13383 1fx1:A (2.0) BS01 FMN ? GO:0009055 ... P00323 N/A
    13384 1fx4:A (1.9) BS01 MG 4.6.1.1 GO:0009190 ... Q99280 11157750
    13385 1fx5:A (2.2) BS01 MN ? GO:0030246 ... P22972 11090284
    13386 1fx5:A (2.2) BS02 CA ? GO:0030246 ... P22972 11090284
    13387 1fx5:B (2.2) BS01 MN ? GO:0030246 ... P22972 11090284
    13388 1fx5:B (2.2) BS02 CA ? GO:0030246 ... P22972 11090284
    13389 1fx6:A (2.06) BS01 PO4 2.5.1.55 GO:0005737 ... O66496 11115499
    13390 1fx6:B (2.06) BS01 PO4 2.5.1.55 GO:0005737 ... O66496 11115499
    13391 1fx7:A (2.0) BS01 CO ? GO:0003677 ... P9WMH1 11053439
    13392 1fx7:A (2.0) BS02 CO ? GO:0003677 ... P9WMH1 11053439
    13393 1fx7:A (2.0) BS03 CO ? GO:0003677 ... P9WMH1 11053439
    13394 1fx7:B (2.0) BS01 CO ? GO:0003677 ... P9WMH1 11053439
    13395 1fx7:B (2.0) BS02 CO ? GO:0003677 ... P9WMH1 11053439
    13396 1fx7:B (2.0) BS03 CO ? GO:0003677 ... P9WMH1 11053439
    13397 1fx7:C (2.0) BS01 CO ? GO:0003677 ... P9WMH1 11053439
    13398 1fx7:C (2.0) BS02 CO ? GO:0003677 ... P9WMH1 11053439
    13399 1fx7:C (2.0) BS03 CO ? GO:0003677 ... P9WMH1 11053439
    13400 1fx7:D (2.0) BS01 CO ? GO:0003677 ... P9WMH1 11053439

    Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).
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