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BioLiP
Download all results in tab-seperated text for 832530 receptor-ligand interactions, whose format is explained at readme.txt.
  • Hover over PDB to view the title of the structure. Click PDB to view the structure at the RCSB PDB database. Resolution -1.00 means the resolution is unavailable, e.g., for NMR structures.
  • Click Site # to view the binding site structure. Hover over Site # to view the binding residues.
  • Hover over Ligand to view the full ligand name. Click Ligand to view the 2D diagram and other detail information of the ligand.
  • Hover over EC number to view the full name of enzymatic activity.
  • Hover over GO terms to view all GO terms.
  • Hover over UniProt to view the protein name.
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    # PDB
    (Resolution Å)
    Site # Ligand EC number GO terms UniProt PubMed Binding
    affinity
    829001 8wq2:AS2P (4.1) BS01 rna ? GO:0003735 ... P39478 38599770
    829002 8wq2:AS2P (4.1) BS02 UNK ? GO:0003735 ... P39478 38599770
    829003 8wq2:AS2P (4.1) BS03 UNK ? GO:0003735 ... P39478 38599770
    829004 8wq2:AS2P (4.1) BS04 UNK ? GO:0003735 ... P39478 38599770
    829005 8wq2:AS3P (4.1) BS01 rna ? GO:0003676 ... Q4JB46 38599770
    829006 8wq2:AS4E (4.1) BS01 rna ? GO:0003723 ... O05634 38599770
    829007 8wq2:AS4P (4.1) BS01 rna ? GO:0003723 ... P39467 38599770
    829008 8wq2:AS5P (4.1) BS01 rna ? GO:0003723 ... O05641 38599770
    829009 8wq2:AS5P (4.1) BS02 UNK ? GO:0003723 ... O05641 38599770
    829010 8wq2:AS5P (4.1) BS03 UNK ? GO:0003723 ... O05641 38599770
    829011 8wq2:AS6E (4.1) BS01 rna ? GO:0003735 ... Q4JAI1 38599770
    829012 8wq2:AS7P (4.1) BS01 rna ? GO:0000028 ... P17198 38599770
    829013 8wq2:AS8E (4.1) BS01 rna ? GO:0000462 ... Q4JAP5 38599770
    829014 8wq2:AS8P (4.1) BS01 rna ? GO:0003735 ... O05636 38599770
    829015 8wq2:AS9P (4.1) BS01 rna ? GO:0000462 ... P39468 38599770
    829016 8wq2:S10P (4.1) BS01 rna ? GO:0000049 ... P17199 38599770
    829017 8wq2:S11P (4.1) BS01 rna ? GO:0003735 ... P39469 38599770
    829018 8wq2:S12P (4.1) BS01 rna ? GO:0003735 ... P11524 38599770
    829019 8wq2:S12P (4.1) BS02 rna ? GO:0003735 ... P11524 38599770
    829020 8wq2:S13P (4.1) BS01 rna ? GO:0003676 ... P39470 38599770
    829021 8wq2:S14P (4.1) BS01 rna ? GO:0003723 ... O05635 38599770
    829022 8wq2:S15P (4.1) BS01 rna ? GO:0003735 ... Q4JAI3 38599770
    829023 8wq2:S17E (4.1) BS01 rna ? GO:0003735 ... Q4JAX5 38599770
    829024 8wq2:S17P (4.1) BS01 rna ? GO:0003735 ... Q4JB49 38599770
    829025 8wq2:S19E (4.1) BS01 rna ? GO:0000028 ... Q4J8U1 38599770
    829026 8wq2:S19P (4.1) BS01 rna ? GO:0003723 ... Q4JB44 38599770
    829027 8wq2:S24E (4.1) BS01 rna ? GO:0003735 ... Q4JAF9 38599770
    829028 8wq2:S27A (4.1) BS01 rna ? GO:0003735 ... Q4JAG0 38599770
    829029 8wq2:S27E (4.1) BS01 rna ? GO:0003735 ... Q4J9B1 38599770
    829030 8wq2:S28E (4.1) BS01 rna ? GO:0003735 ... Q4JAV1 38599770
    829031 8wq2:S3AE (4.1) BS01 rna ? GO:0003735 ... Q4JB17 38599770
    829032 8wq2:SL7A (4.1) BS01 rna ? GO:0001682 ... Q4J8P1 38599770
    829033 8wq4:AS2P (4.53) BS01 rna ? GO:0003735 ... P39478 38599770
    829034 8wq4:AS3P (4.53) BS01 rna ? GO:0003676 ... Q4JB46 38599770
    829035 8wq4:AS4E (4.53) BS01 rna ? GO:0003723 ... O05634 38599770
    829036 8wq4:AS4P (4.53) BS01 rna ? GO:0003723 ... P39467 38599770
    829037 8wq4:AS5P (4.53) BS01 rna ? GO:0003723 ... O05641 38599770
    829038 8wq4:AS5P (4.53) BS02 UNK ? GO:0003723 ... O05641 38599770
    829039 8wq4:AS5P (4.53) BS03 UNK ? GO:0003723 ... O05641 38599770
    829040 8wq4:AS6E (4.53) BS01 rna ? GO:0003735 ... Q4JAI1 38599770
    829041 8wq4:AS7P (4.53) BS01 rna ? GO:0000028 ... P17198 38599770
    829042 8wq4:AS8E (4.53) BS01 rna ? GO:0000462 ... Q4JAP5 38599770
    829043 8wq4:AS8P (4.53) BS01 rna ? GO:0003735 ... O05636 38599770
    829044 8wq4:AS8P (4.53) BS02 UNK ? GO:0003735 ... O05636 38599770
    829045 8wq4:AS9P (4.53) BS01 rna ? GO:0000462 ... P39468 38599770
    829046 8wq4:S10P (4.53) BS01 rna ? GO:0000049 ... P17199 38599770
    829047 8wq4:S11P (4.53) BS01 rna ? GO:0003735 ... P39469 38599770
    829048 8wq4:S12P (4.53) BS01 rna ? GO:0003735 ... P11524 38599770
    829049 8wq4:S12P (4.53) BS02 rna ? GO:0003735 ... P11524 38599770
    829050 8wq4:S13P (4.53) BS01 rna ? GO:0003676 ... P39470 38599770
    829051 8wq4:S14P (4.53) BS01 rna ? GO:0003723 ... O05635 38599770
    829052 8wq4:S15P (4.53) BS01 rna ? GO:0003735 ... Q4JAI3 38599770
    829053 8wq4:S17E (4.53) BS01 rna ? GO:0003735 ... Q4JAX5 38599770
    829054 8wq4:S17P (4.53) BS01 rna ? GO:0003735 ... Q4JB49 38599770
    829055 8wq4:S19E (4.53) BS01 rna ? GO:0000028 ... Q4J8U1 38599770
    829056 8wq4:S19P (4.53) BS01 rna ? GO:0003723 ... Q4JB44 38599770
    829057 8wq4:S24E (4.53) BS01 rna ? GO:0003735 ... Q4JAF9 38599770
    829058 8wq4:S27A (4.53) BS01 rna ? GO:0003735 ... Q4JAG0 38599770
    829059 8wq4:S27E (4.53) BS01 rna ? GO:0003735 ... Q4J9B1 38599770
    829060 8wq4:S3AE (4.53) BS01 rna ? GO:0003735 ... Q4JB17 38599770
    829061 8wq4:SL7A (4.53) BS01 rna ? GO:0001682 ... Q4J8P1 38599770
    829062 8wq9:A (1.97) BS01 ABU 3.5.2.2 GO:0004157 ... Q9I676 38056157
    829063 8wq9:A (1.97) BS02 ABU 3.5.2.2 GO:0004157 ... Q9I676 38056157
    829064 8wq9:A (1.97) BS03 ZN 3.5.2.2 GO:0004157 ... Q9I676 38056157
    829065 8wq9:A (1.97) BS04 ZN 3.5.2.2 GO:0004157 ... Q9I676 38056157
    829066 8wq9:B (1.97) BS01 ABU 3.5.2.2 GO:0004157 ... Q9I676 38056157
    829067 8wq9:B (1.97) BS02 ABU 3.5.2.2 GO:0004157 ... Q9I676 38056157
    829068 8wq9:B (1.97) BS03 ZN 3.5.2.2 GO:0004157 ... Q9I676 38056157
    829069 8wq9:B (1.97) BS04 ZN 3.5.2.2 GO:0004157 ... Q9I676 38056157
    829070 8wqa:B (3.39) BS01 peptide ? GO:0002070 ... Q9UK73 38670995
    829071 8wqa:D (3.39) BS01 peptide ? GO:0002070 ... Q9UK73 38670995
    829072 8wqa:I (3.39) BS01 ZN 2.3.2.27
    2.3.2.32
    GO:0008270 ... P62877 38670995
    829073 8wqa:I (3.39) BS02 ZN 2.3.2.27
    2.3.2.32
    GO:0008270 ... P62877 38670995
    829074 8wqa:I (3.39) BS03 ZN 2.3.2.27
    2.3.2.32
    GO:0008270 ... P62877 38670995
    829075 8wqa:J (3.39) BS01 ZN 2.3.2.27
    2.3.2.32
    GO:0008270 ... P62877 38670995
    829076 8wqa:J (3.39) BS02 ZN 2.3.2.27
    2.3.2.32
    GO:0008270 ... P62877 38670995
    829077 8wqb:E (3.37) BS01 ZN 2.3.2.27
    2.3.2.32
    GO:0008270 ... P62877 38670995
    829078 8wqb:E (3.37) BS02 ZN 2.3.2.27
    2.3.2.32
    GO:0008270 ... P62877 38670995
    829079 8wqb:E (3.37) BS03 ZN 2.3.2.27
    2.3.2.32
    GO:0008270 ... P62877 38670995
    829080 8wqb:I (3.37) BS01 ZN 2.3.2.27
    2.3.2.32
    GO:0008270 ... P62877 38670995
    829081 8wqb:I (3.37) BS02 ZN 2.3.2.27
    2.3.2.32
    GO:0008270 ... P62877 38670995
    829082 8wqb:I (3.37) BS03 ZN 2.3.2.27
    2.3.2.32
    GO:0008270 ... P62877 38670995
    829083 8wqb:J (3.37) BS01 peptide ? GO:0002070 ... Q9UK73 38670995
    829084 8wqc:F (3.54) BS01 ZN 2.3.2.27
    2.3.2.32
    GO:0008270 ... P62877 38670995
    829085 8wqc:F (3.54) BS02 ZN 2.3.2.27
    2.3.2.32
    GO:0008270 ... P62877 38670995
    829086 8wqc:F (3.54) BS03 ZN 2.3.2.27
    2.3.2.32
    GO:0008270 ... P62877 38670995
    829087 8wqc:J (3.54) BS01 ZN 2.3.2.27
    2.3.2.32
    GO:0008270 ... P62877 38670995
    829088 8wqc:J (3.54) BS02 ZN 2.3.2.27
    2.3.2.32
    GO:0008270 ... P62877 38670995
    829089 8wqc:J (3.54) BS03 ZN 2.3.2.27
    2.3.2.32
    GO:0008270 ... P62877 38670995
    829090 8wqd:D (3.55) BS01 peptide ? GO:0002070 ... Q9UK73 38670995
    829091 8wqe:B (3.38) BS01 peptide ? GO:0002070 ... Q9UK73 38670995
    829092 8wqe:I (3.38) BS01 ZN 2.3.2.27
    2.3.2.32
    GO:0008270 ... P62877 38670995
    829093 8wqe:I (3.38) BS02 ZN 2.3.2.27
    2.3.2.32
    GO:0008270 ... P62877 38670995
    829094 8wqe:I (3.38) BS03 ZN 2.3.2.27
    2.3.2.32
    GO:0008270 ... P62877 38670995
    829095 8wqe:J (3.38) BS01 ZN 2.3.2.27
    2.3.2.32
    GO:0008270 ... P62877 38670995
    829096 8wqe:J (3.38) BS02 ZN 2.3.2.27
    2.3.2.32
    GO:0008270 ... P62877 38670995
    829097 8wqe:J (3.38) BS03 ZN 2.3.2.27
    2.3.2.32
    GO:0008270 ... P62877 38670995
    829098 8wqf:E (3.27) BS01 ZN 2.3.2.27
    2.3.2.32
    GO:0008270 ... P62877 38670995
    829099 8wqf:E (3.27) BS02 ZN 2.3.2.27
    2.3.2.32
    GO:0008270 ... P62877 38670995
    829100 8wqf:E (3.27) BS03 ZN 2.3.2.27
    2.3.2.32
    GO:0008270 ... P62877 38670995
    829101 8wqf:I (3.27) BS01 ZN 2.3.2.27
    2.3.2.32
    GO:0008270 ... P62877 38670995
    829102 8wqf:I (3.27) BS02 ZN 2.3.2.27
    2.3.2.32
    GO:0008270 ... P62877 38670995
    829103 8wqf:I (3.27) BS03 ZN 2.3.2.27
    2.3.2.32
    GO:0008270 ... P62877 38670995
    829104 8wqf:J (3.27) BS01 peptide ? GO:0002070 ... Q9UK73 38670995
    829105 8wqg:F (4.09) BS01 ZN 2.3.2.27
    2.3.2.32
    GO:0008270 ... P62877 38670995
    829106 8wqg:F (4.09) BS02 ZN 2.3.2.27
    2.3.2.32
    GO:0008270 ... P62877 38670995
    829107 8wqg:F (4.09) BS03 ZN 2.3.2.27
    2.3.2.32
    GO:0008270 ... P62877 38670995
    829108 8wqg:J (4.09) BS01 ZN 2.3.2.27
    2.3.2.32
    GO:0008270 ... P62877 38670995
    829109 8wqg:J (4.09) BS02 ZN 2.3.2.27
    2.3.2.32
    GO:0008270 ... P62877 38670995
    829110 8wqg:J (4.09) BS03 ZN 2.3.2.27
    2.3.2.32
    GO:0008270 ... P62877 38670995
    829111 8wqh:B (3.44) BS01 ZN 2.3.2.27
    2.3.2.32
    GO:0008270 ... P62877 38670995
    829112 8wqh:B (3.44) BS02 ZN 2.3.2.27
    2.3.2.32
    GO:0008270 ... P62877 38670995
    829113 8wqh:B (3.44) BS03 ZN 2.3.2.27
    2.3.2.32
    GO:0008270 ... P62877 38670995
    829114 8wqh:D (3.44) BS01 peptide ? GO:0002070 ... Q9UK73 38670995
    829115 8wqh:H (3.44) BS01 peptide ? GO:0002070 ... Q9UK73 38670995
    829116 8wqh:J (3.44) BS01 ZN 2.3.2.27
    2.3.2.32
    GO:0008270 ... P62877 38670995
    829117 8wqh:J (3.44) BS02 ZN 2.3.2.27
    2.3.2.32
    GO:0008270 ... P62877 38670995
    829118 8wqh:J (3.44) BS03 ZN 2.3.2.27
    2.3.2.32
    GO:0008270 ... P62877 38670995
    829119 8wqi:D (3.5) BS01 peptide ? GO:0002070 ... Q9UK73 38670995
    829120 8wqm:A (1.796) BS01 CO 1.13.11.27 GO:0003868 ... P93836 N/A
    829121 8wqm:A (1.796) BS02 AOQ 1.13.11.27 GO:0003868 ... P93836 N/A
    829122 8wr2:A (1.94) BS01 GLC 2.7.1.35 GO:0000287 ... O00764 38150934
    829123 8wr2:A (1.94) BS02 LU2 2.7.1.35 GO:0000287 ... O00764 38150934
    829124 8wr2:B (1.94) BS01 GLC 2.7.1.35 GO:0000287 ... O00764 38150934
    829125 8wr2:B (1.94) BS02 LU2 2.7.1.35 GO:0000287 ... O00764 38150934
    829126 8wrb:R (2.91) BS01 SER ? GO:0004930 ... Q9UPC5 38048360
    829127 8wrb:R (2.91) BS02 UBL ? GO:0004930 ... Q9UPC5 38048360
    829128 8wrj:A (1.85) BS01 6JI 2.4.1.- GO:0008194 ... W8JMV4 N/A
    829129 8wrj:A (1.85) BS02 UDP 2.4.1.- GO:0008194 ... W8JMV4 N/A
    829130 8wrk:A (2.03) BS01 PIT 2.4.1.- GO:0008194 ... W8JMV4 N/A
    829131 8wrk:A (2.03) BS02 UDP 2.4.1.- GO:0008194 ... W8JMV4 N/A
    829132 8wrz:A (3.6) BS01 peptide ? GO:0000139 ... P49407 38102480
    829133 8wrz:R (3.6) BS01 8D0 ? GO:0004930 ... P0ABE7
    P21554
    38102480
    829134 8wsm:A (2.7) BS01 ADP 3.6.4.- N/A Q96P20 38116417
    829135 8wsm:A (2.7) BS02 XE3 3.6.4.- N/A Q96P20 38116417
    829136 8wsw:A (2.5) BS01 LH0 2.7.11.1 GO:0004672 ... P53671 N/A
    829137 8wsw:B (2.5) BS01 LH0 2.7.11.1 GO:0004672 ... P53671 N/A
    829138 8wsw:C (2.5) BS01 LH0 2.7.11.1 GO:0004672 ... P53671 N/A
    829139 8wsw:D (2.5) BS01 LH0 2.7.11.1 GO:0004672 ... P53671 N/A
    829140 8wt1:A (2.0) BS01 ALA ? GO:0004252 ... A0A3L7D5Q2 38426217
    829141 8wt1:B (2.0) BS01 ALA ? GO:0004252 ... A0A3L7D5Q2 38426217
    829142 8wt1:C (2.0) BS01 ALA ? GO:0004252 ... A0A3L7D5Q2 38426217
    829143 8wt1:D (2.0) BS01 ALA ? GO:0004252 ... A0A3L7D5Q2 38426217
    829144 8wt1:E (2.0) BS01 ALA ? GO:0004252 ... A0A3L7D5Q2 38426217
    829145 8wt1:F (2.0) BS01 ALA ? GO:0004252 ... A0A3L7D5Q2 38426217
    829146 8wt1:G (2.0) BS01 ALA ? GO:0004252 ... A0A3L7D5Q2 38426217
    829147 8wt1:H (2.0) BS01 ALA ? GO:0004252 ... A0A3L7D5Q2 38426217
    829148 8wtb:B (2.9) BS01 ZN ? GO:0005507 ... P37569 38625935
    829149 8wtb:D (2.9) BS01 ZN ? GO:0005507 ... P37569 38625935
    829150 8wtc:B (2.8) BS01 ZN ? GO:0005507 ... P37569 38625935
    829151 8wtc:D (2.8) BS01 ZN ? GO:0005507 ... P37569 38625935
    829152 8wtf:A (2.0) BS01 8CG 2.7.11.1 GO:0000287 ... Q9NWZ3 N/A
    829153 8wtq:A (2.0) BS01 KUO 2.5.1.21 N/A P37268 38517948
    829154 8wtr:A (2.0) BS01 KV3 2.5.1.21 N/A P37268 38517948
    829155 8wu1:R (3.2) BS01 KCA ? GO:0004930 ... P21554
    P30518
    N/A
    829156 8wu8:A (2.81) BS01 peptide 3.1.11.2 GO:0000077 ... Q99638 38354779
    829157 8wuc:A (2.5) BS01 ADP 5.6.1.7 GO:0005524 ... A0A2Z6DW38 38492570
    829158 8wuc:B (2.5) BS01 ADP 5.6.1.7 GO:0005524 ... A0A2Z6DW38 38492570
    829159 8wuc:C (2.5) BS01 ADP 5.6.1.7 GO:0005524 ... A0A2Z6DW38 38492570
    829160 8wuc:D (2.5) BS01 ADP 5.6.1.7 GO:0005524 ... A0A2Z6DW38 38492570
    829161 8wuc:E (2.5) BS01 ADP 5.6.1.7 GO:0005524 ... A0A2Z6DW38 38492570
    829162 8wuc:F (2.5) BS01 ADP 5.6.1.7 GO:0005524 ... A0A2Z6DW38 38492570
    829163 8wuc:G (2.5) BS01 ADP 5.6.1.7 GO:0005524 ... A0A2Z6DW38 38492570
    829164 8wuc:H (2.5) BS01 ADP 5.6.1.7 GO:0005524 ... A0A2Z6DW38 38492570
    829165 8wuc:I (2.5) BS01 ADP 5.6.1.7 GO:0005524 ... A0A2Z6DW38 38492570
    829166 8wuc:J (2.5) BS01 ADP 5.6.1.7 GO:0005524 ... A0A2Z6DW38 38492570
    829167 8wuc:K (2.5) BS01 ADP 5.6.1.7 GO:0005524 ... A0A2Z6DW38 38492570
    829168 8wuc:L (2.5) BS01 ADP 5.6.1.7 GO:0005524 ... A0A2Z6DW38 38492570
    829169 8wuc:M (2.5) BS01 ADP 5.6.1.7 GO:0005524 ... A0A2Z6DW38 38492570
    829170 8wuc:N (2.5) BS01 ADP 5.6.1.7 GO:0005524 ... A0A2Z6DW38 38492570
    829171 8wug:A (1.7) BS01 ZN 1.14.11.66 N/A Q6B0I6 N/A
    829172 8wul:I (2.36) BS01 peptide ? N/A A0A583ZB34 38684865
    829173 8wul:L (2.36) BS01 peptide ? N/A A0A583ZB34 38684865
    829174 8wul:O (2.36) BS01 peptide ? N/A A0A583ZB34 38684865
    829175 8wul:R (2.36) BS01 peptide ? N/A A0A583ZB34 38684865
    829176 8wus:A (2.9) BS01 dna 3.1.-.- GO:0003677 ... Q99ZW2 38811740
    829177 8wus:A (2.9) BS02 dna 3.1.-.- GO:0003677 ... Q99ZW2 38811740
    829178 8wus:A (2.9) BS03 rna 3.1.-.- GO:0003677 ... Q99ZW2 38811740
    829179 8wus:E (2.9) BS01 rna ? N/A Q8UN00 38811740
    829180 8wus:E (2.9) BS02 dna ? N/A Q8UN00 38811740
    829181 8wut:A (3.0) BS01 dna 3.1.-.- GO:0003677 ... Q99ZW2 38811740
    829182 8wut:A (3.0) BS02 dna 3.1.-.- GO:0003677 ... Q99ZW2 38811740
    829183 8wut:A (3.0) BS03 rna 3.1.-.- GO:0003677 ... Q99ZW2 38811740
    829184 8wut:E (3.0) BS01 rna ? N/A Q8UN00 38811740
    829185 8wut:E (3.0) BS02 dna ? N/A Q8UN00 38811740
    829186 8wuu:A (3.2) BS01 dna 3.1.-.- GO:0003677 ... Q99ZW2 38811740
    829187 8wuu:A (3.2) BS02 dna 3.1.-.- GO:0003677 ... Q99ZW2 38811740
    829188 8wuu:A (3.2) BS03 rna 3.1.-.- GO:0003677 ... Q99ZW2 38811740
    829189 8wuv:A (3.0) BS01 dna 3.1.-.- GO:0003677 ... Q99ZW2 38811740
    829190 8wuv:A (3.0) BS02 dna 3.1.-.- GO:0003677 ... Q99ZW2 38811740
    829191 8wuv:A (3.0) BS03 rna 3.1.-.- GO:0003677 ... Q99ZW2 38811740
    829192 8wuv:E (3.0) BS01 rna ? N/A Q8UN00 38811740
    829193 8wuv:E (3.0) BS02 dna ? N/A Q8UN00 38811740
    829194 8wuw:A (2.6) BS01 ANP 5.6.1.7 GO:0005524 ... D3DK86 38492570
    829195 8wuw:B (2.6) BS01 ANP 5.6.1.7 GO:0005524 ... D3DK86 38492570
    829196 8wuw:C (2.6) BS01 ANP 5.6.1.7 GO:0005524 ... D3DK86 38492570
    829197 8wuw:D (2.6) BS01 ANP 5.6.1.7 GO:0005524 ... D3DK86 38492570
    829198 8wuw:E (2.6) BS01 ANP 5.6.1.7 GO:0005524 ... D3DK86 38492570
    829199 8wuw:F (2.6) BS01 ANP 5.6.1.7 GO:0005524 ... D3DK86 38492570
    829200 8wuw:G (2.6) BS01 ANP 5.6.1.7 GO:0005524 ... D3DK86 38492570

    Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).
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