Structure of PDB 6yhj Chain H

Receptor sequence
>6yhjH (length=253) Species: 9606 (Homo sapiens) [Search protein sequence]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWKG
QPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDS
GGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVID
QFG
3D structure
PDB6yhj Thrombin in complex with D-Phe-Pro-2-chlorothiophen derivative (16e)
ChainH
Resolution1.44 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 E192 G193 D194 S195 G196
Catalytic site (residue number reindexed from 1) H43 D99 E197 G198 D199 S200 G201
Enzyme Commision number 3.4.21.5: thrombin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide H F34 L40 L65 R73 T74 R75 Y76 K81 I82 F19 L26 L60 R68 T69 R70 Y71 K77 I78
BS02 OQZ H I47 L123 P124 F232 K235 I33 L120 P121 F239 K242
BS03 OQZ H Y60A N98 C191 S214 W215 G216 Y47 N95 C196 S221 W222 G223
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6yhj, PDBe:6yhj, PDBj:6yhj
PDBsum6yhj
PubMed
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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