Structure of PDB 7pnf Chain D

Receptor sequence

>7pnfD (length=1141) Species: 9606 (Homo sapiens)

STARCSLFGSDFVNTFDGSMYSFAGYCSYLLAGGCQKRSFSIIGDFQNGK
RVSLSVYLGEFFDIHLFVNGTVTQGDQRVSMPYASKGLYLETEAGYYKLS
GEAYGFVARIDGSGNFQVLLSDRYFNKTCGLCGNFNIFAEDDFMTQEGTL
TSDPYDFANSWALSSGEQWCERASPPSSSCLWEQCQLLKSTSVFARCHPL
VDPEPFVALCEKTLCECAGGLECACPALLEYARTCAQEGMVLYGWTDHSA
CSPVCPAGMEYRQCVSPCARTCQSLHINEMCQERCVDGCSCPEGQLLDEG
LCVESTECPCVHSGKRYPPGTSLSRDCNTCICRNSQWICSNEECPGECLV
TGQSHFKSFDNRYFTFSGICQYLLARDCQDHSFSIVIETVQCADDRDAVC
TRSVTVRLPGLHNSLVKLKHGAGVAMDGQDVQLPLLKGDLRIQHTVTASV
RLSYGEDLQMDWDGRGRLLVKLSPVYAGKTCGLCGNYNGNQGDDFLTPSG
LAEPRVEDFGNAWKLHGDCQDLQKQHSDPCALNPRMTRFSEEACAVLTSP
TFEACHRAVSPLPYLRNCRYDVCSCSDGRECLCGALASYAAACAGRGVRV
AWREPGRCELNCPKGQVYLQCGTPCNLTCRSLSYPDEECNEACLEGCFCP
PGLYMDERGDCVPKAQCPCYYDGEIFQPEDIFSDHHTMCYCEDGFMHCTM
CRPPMVKLVCPADNLRAEGLECTKTCQNYDLECMSMGCVSGCLCPPGMVR
HENRCVALERCPCFHQGKEYAPGETVKIGCNTCVCRDRKWNCTDHVCDAT
CSTIGMAHYLTFDGLKYLFPGECQYVLVQDYCGSNPGTFRILVGNKGCSH
PSVKCKKRVTILVEGGEIELFDGEVNVKRPMKDETHFEVVESGRYIILLL
GKALSVVWDRHLSISVVLKQTYQEKVCGLCGNFDGIQNNDLTSSNLQVEE
DPVDFGNSWKVSSQCADTRKVPLDSSPATCHNNIMKQTMVDSSCRILTSD
VFQDCNKLVDPEPYLDVCIYDTCSCESIGDCACFCDTIAAYAHVCAQHGK
VVTWRTATLCPQSCEERNLRENGYECEWRYNSCAPACQVTCQHPEPLACP
VQCVEGCHAHCPPGKILDELLQTCVDPEDCPVCEVAGRRFA

3D structure

• PDB: 7pnf Helical self-assembly of a mucin segment suggests an evolutionary origin for von Willebrand factor tubules.
• Chain: D
• Resolution: 4.35 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	CA	D	N164 N166 F168 D171 D172	N134 N136 F138 D141 D142
BS02	CA	D	N526 N528 N530 D533 D534	N486 N488 N490 D493 D494
BS03	CA	D	D879 N998 F999 D1000 I1002 D1006	D813 N932 F933 D934 I936 D940

External links

• PDB: RCSB:7pnf, PDBe:7pnf, PDBj:7pnf
• PDBsum: 7pnf
• PubMed: 35377815
• UniProt: P04275|VWF_HUMAN von Willebrand factor (Gene Name=VWF)