Structure of PDB 5wn3 Chain B

Receptor sequence
>5wn3B (length=275) Species: 9606 (Homo sapiens) [Search protein sequence]
LYEDPPDQKTSPSGKPATLKICSWNVDGLRAWIKKKGLDWVKEEAPDILC
LQETKCSENKLPAELQELPGLSHQYWSAPSDKEGYSGVGLLSRQAPLKVS
YGIGDEEHDQEGRVIVAEFDSFVLVTAYVPNAGRGLVRLEYRQRWDEAFR
KFLKGLASRKPLVLCGDLNVAHEEIDLRNPKGNKKNAGFTPQERQGFGEL
LQAVPLADSFRHLYPNTPYAYTAWTYMMNARSKNVGWRLDYFLLSHSLLP
ALCDSKIRSKALGSDHCPITLYLAL
3D structure
PDB5wn3 Molecular snapshots of APE1 proofreading mismatches and removing DNA damage.
ChainB
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N68 E96 D210 N212 D283 D308 H309
Catalytic site (residue number reindexed from 1) N25 E53 D167 N169 D240 D265 H266
Enzyme Commision number 3.1.11.2: exodeoxyribonuclease III.
3.1.21.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna B M271 K276 W280 M228 K233 W237
BS02 dna B N174 A266 T268 W280 L282 H309 N131 A223 T225 W237 L239 H266
BS03 dna B G71 R73 A74 K78 K98 E126 G127 Y269 M270 G28 R30 A31 K35 K55 E83 G84 Y226 M227
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003824 catalytic activity
GO:0004518 nuclease activity
GO:0004519 endonuclease activity
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:5wn3, PDBe:5wn3, PDBj:5wn3
PDBsum5wn3
PubMed29374164
UniProtP27695|APEX1_HUMAN DNA repair nuclease/redox regulator APEX1 (Gene Name=APEX1)

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