Structure of PDB 2y00 Chain B

Receptor sequence

>2y00B (length=298) Species: 9103 (Meleagris gallopavo)

AELLSQQWEAGMSLLMALVVLLIVAGNVLVIAAIGSTQRLQTLTNLFITS
LACADLVVGLLVVPFGATLVVRGTWLWGSFLCELWTSLDVLCVTASIETL
CVIAIDRYLAITSPFRYQSLMTRARAKVIICTVWAISALVSFLPIMMHWW
RDEDPQALKCYQDPGCCDFVTNRAYAIASSIISFYIPLLIMIFVALRVYR
EAKEQIRKIDRASKRKTSRVMLMREHKALKTLGIIMGVFTLCWLPFFLVN
IVNVFNRDLVPDWLFVAFNWLGYANSAMNPIIYCRSPDFRKAFKRLLA

3D structure

• PDB: 2y00 The Structural Basis for Agonist and Partial Agonist Action on a Beta1-Adrenergic Receptor
• Chain: B
• Resolution: 2.5 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	Y01	B	R205 A206 I209	R173 A174 I177
BS02	2CV	B	L152 R157	L120 R125
BS03	Y01	B	E130 C133 R157 V160 I161 T164	E98 C101 R125 V128 I129 T132
BS04	Y01	B	L78 C85 K159 W166	L46 C53 K127 W134
BS05	2CV	B	W181 R183	W149 R151
BS06	2CV	B	A227 Y231	A195 Y199
BS07	Y00	B	W117 T118 D121 V122 V125 S211 F307 N329 W330 Y333	W85 T86 D89 V90 V93 S179 F247 N269 W270 Y273

Gene Ontology

Molecular Function

• GO:0004930 G protein-coupled receptor activity
• GO:0004935 adrenergic receptor activity
• GO:0004940 beta1-adrenergic receptor activity

Biological Process

• GO:0007186 G protein-coupled receptor signaling pathway
• GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
• GO:0045823 positive regulation of heart contraction

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:2y00, PDBe:2y00, PDBj:2y00
• PDBsum: 2y00
• PubMed: 21228877
• UniProt: P07700|ADRB1_MELGA Beta-1 adrenergic receptor (Gene Name=ADRB1)