Structure of PDB 7yzx Chain A

Receptor sequence
>7yzxA (length=930) Species: 1314 (Streptococcus pyogenes) [Search protein sequence]
TPATSKATIRDLNDPSQVKTLQEKAGKGAGTVVAVIDAGFDKNHEAWRLT
DKTKARYQSKEDLEKAKKEHGITYGEWVNDKVAYYHDYSKDGKTAVDQEH
GTHVSGILSGNAPSETKEPYRLEGAMPEAQLLLMRVEIVNGLADYARNYA
QAIRDAVNLGAKVINMSFGNAALAYANLPDETKKAFDYAKSKGVSIVTSA
GNDSSFGGKTRLPLADHPDYGVVGTPAAADSTLTVASYSPDKQLTETATV
KTDDHQAKEMPVLSTNRFEPNKAYDYAYANRGMKEDDFKDVKGKIALIER
GDIDFKDKIANAKKAGAVGVLIYDNQDKGFPIELPNVDQMPAAFISRKDG
LLLKDNSKKTITFNATPKVLPTASDTKLSRFSSWGLTADGNIKPDIAAPG
QDILSSVANNKYAKLSGTSMSAPLVAGIMGLLQKQYETQYPDMTPSERLD
LAKKVLMSSATALYDEDEKAYFSPRQQGAGAVDAKKASAATMYVTDKDNT
SSKVHLNNVSDKFEVTVTVHNKSDKPQELYYQATVQTDKVDGKHFALAPK
ALYETSWQKITIPANSSKQVTVPIDASRFSKDLLAQMKNGYFLEGFVRFK
QDPKKEELMSIPYIGFRGDFGNLSALEKPIYDSKDGSSYYHEANSDAKDQ
LDGDGLQFYALKNNFTALTTESNPWTIIKAVKEGVENIESSEITETIFAG
TFAKQDDDSHYYIHRHANGKPYAAISPNGDGNRDYVQFQGTFLRNAKNLV
AEVLDKEGNVVWTSEVTEQVVKNYNNDLASTLGSTRFEKTRWDGKDKDGK
VVVNGTYTYRVRYTPISSGAKEQHTDFDVIVDNTTPEVATSATFSTEDRR
LTLASKPKTSQPIYRERIAYTYMDEDPTTEYISPNEDGTFTLPEEAETGT
VPLKMSDFTYVVEDMAGNITYTPVTKLLEG
3D structure
PDB7yzx X-ray diffraction data for the C5a-peptidase mutant with modified activity and specificity.
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.110: C5a peptidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A K302 R393 D397 F398 I425 K209 R300 D304 F305 I332
BS02 CA A S822 N824 D826 N828 D830 S726 N728 D730 N732 D734
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0005618 cell wall
GO:0016020 membrane

View graph for
Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7yzx, PDBe:7yzx, PDBj:7yzx
PDBsum7yzx
PubMed36478677
UniProtP15926|C5AP_STRPY C5a peptidase (Gene Name=scpA)

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