Structure of PDB 7t3r Chain A

Receptor sequence
>7t3rA (length=2130) Species: 9606 (Homo sapiens) [Search protein sequence]
SSFLHIGDIVSLYAEGSVNGFISTLGLVDDRCVVEPAAGDLDNPPKKFRD
CLFKVCPMNRYSAQKQYWKAKQVVLLQKLQHAAQMEQKQNDTENKKVHGD
VVKYGSVIQLLHMKSNKYLTVNKRLPALLEKNAMRVTLDATGNEGSWLFI
QPFWKLRSNGDNVVVGDKVILNPVNAGQPLHASNYELSDNAGCKEVNSVN
CNTSWKINLFMQFRDHLEEVLKGGDVVRLFHAEQEKFLTCDEYKGKLQVF
LRTTLRQSATSATSSNALWEVEVVHHDPCRGGAGHWNGLYRFKHLATGNY
LAAEENPSYKIKYCLVAVPHGNDIASLFELDPTTLQKTDSFVPRNSYVRL
RHLCTNTWIQSTNVPIDIEEERPIRLMLGTCPTKEDKEAFAIVSVPVSEI
RDLDFANDASSMLASAVEKLNEGFISQNDRRFVIQLLEDLVFFVSDVPNN
GQNVLDIMVTKPNRERQKLMREQNILKQVFGILKAPFRPLVRLEELSDQK
NAPYQHMFRLCYRVLRHSQEDYRKNQEHIAKQFGMMQSQIGYDILAEDTI
TALLHNNRKLLEKHITKTEVETFVSLVRKNREPRFLDYLSDLCVSNHIAI
PVTQELICKCVLDPKNSDILIRTELEVWLTWTDKNNEHHEKSVRQLAQEA
RAGNAHDENVLSYYRYQLKLFARMCLDRQYLAIDEISQQLGVDLIFLCMA
DEMLPFDLRASFCHLMLHVHVDRDPQELVTPVKFARLWTEIPTAITIKDY
DSNLNNKFANTMEFVEDYLNNVVSEAVPFANEEKNKLTFEVVSLAHNLIY
FGFYSFSELLRLTRTLLGIIDDIVVMETKLKILEILQFILNVRLDYRISY
LLSVFKKEFLDRIGEQAEAMFGLEVDDEGGRMFLRVLIHLTMHDYAPLVS
GALQLLFKHFSQRQEAMHTFKQVQLLISAQDVENYKVIKSELDRLRTMVE
KSELWVENYQIVKGILERLNKMCGVGEQMRKKQQRLLKNMDAHKVMLDLL
QIPYDKGDAKMMEILRYTHQFLQKFCAGNPGNQALLHKHLHLFLTPGLLE
AETMQHIFLNNYQLCSEISEPVLQHFVHLLATHGRHVQYLDFLHTVIKAE
GKYVKKCQDMIMTELTNAGDDVVVFYNDKASLAHLLDMMKAARDGVEDHS
PLMYHISLVDLLAACAEGKNVYTEIKCTSLLPLEDVVSVVTHEDCITEVK
MAYVNFVNHCYVDTEVEMKEIYTSNHIWTLFENFTLDMARVPTLEKYVLS
VVLDTINAFFSSPFSENSTTHQTIVVQLLQSTTRLGSVEACIRTLAMVAK
GRWDYKNIIEKLQDIITALEERLKPLVQAELSVLVDVLHWPELLFLEGSE
AYQRCESGGFLSKLIQHTKDLMESEEKLCIKVLRTLQQMLLKKTKYGDRG
NQLRKMLLQNYLQNWSAIAATQCRLDKEGATKLVCDLITSTKNEKIFQES
IGLAIHLLDGGNTEIQKSFHNLMMSDKKSERFFKVLHDRMKRAQQETKST
MGTSVLIMQPILRFLQLLCENHNRDLQNFLRCQNNKTNYNLVCETLQFLD
IMCGSTTGGLGLLGLYINEDNVGLVIQTLETLTEYCQGPCHENQTCIVTH
ESNGIDIITALILNDISPLCKYRMDLVLQLKDNASKLLLALMESRHDSEN
AERILISLRPQELVDVIKKAYLQVSPREVGHNIYILALQLSRHNKQLQHL
LKPEDPLAYYENHTSQIEIVRQDRSMEQIVFPVPGICQFLTEETKHRLFT
TTEQDEQGSKVSDFFDQSSFLHNEMEWQRKLRSMPLIYWFSRRMTLWGSI
SFNLAVFINIIIAFFYPYIRPLIVALILRSIYYLGIGPTLNILGALNLTN
KIVFVVSFVGNRGTMEFLYHVGYILTSVLGLFAHELFYSILLFDLIYREE
TLFNVIKSVTRNGRSILLTALLALILVYLFSIVGFLFLKDDFILEVDRLS
TERACDTLLMCIVTVMNHGLRNGGGVGDILRKPSKDESLFPARVVYDLLF
FFIVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDKFDN
KTVSFEEHIKLEHNMWNYLYFIVLVRVKNKTDYTGPESYVAQMIKNKNLD
WFPRMRAMSLVAAAAAAAAAAAAAAAAAAA
3D structure
PDB7t3r Structural basis for activation and gating of IP 3 receptors.
ChainA
Resolution3.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C2538 H2558 H2563 C2038 H2058 H2063
BS02 I3P A R266 T268 L269 R270 K507 Y567 R568 K569 R252 T254 L255 R256 K468 Y522 R523 K524
BS03 ATP A E2149 K2152 F2156 F2539 I2559 K2560 H2563 N2564 M2565 W2566 E1742 K1745 F1749 F2039 I2059 K2060 H2063 N2064 M2065 W2066
Gene Ontology
Molecular Function
GO:0000822 inositol hexakisphosphate binding
GO:0005216 monoatomic ion channel activity
GO:0005220 inositol 1,4,5-trisphosphate-gated calcium channel activity
GO:0005262 calcium channel activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0015278 intracellularly gated calcium channel activity
GO:0035091 phosphatidylinositol binding
GO:0043533 inositol 1,3,4,5 tetrakisphosphate binding
GO:0070679 inositol 1,4,5 trisphosphate binding
Biological Process
GO:0006811 monoatomic ion transport
GO:0006816 calcium ion transport
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007613 memory
GO:0019722 calcium-mediated signaling
GO:0030168 platelet activation
GO:0050909 sensory perception of taste
GO:0050913 sensory perception of bitter taste
GO:0050916 sensory perception of sweet taste
GO:0050917 sensory perception of umami taste
GO:0051209 release of sequestered calcium ion into cytosol
GO:0051289 protein homotetramerization
GO:0051592 response to calcium ion
GO:0055074 calcium ion homeostasis
GO:0055085 transmembrane transport
GO:0060291 long-term synaptic potentiation
GO:0070588 calcium ion transmembrane transport
Cellular Component
GO:0005634 nucleus
GO:0005640 nuclear outer membrane
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0005903 brush border
GO:0016020 membrane
GO:0016529 sarcoplasmic reticulum
GO:0030658 transport vesicle membrane
GO:0030667 secretory granule membrane
GO:0031095 platelet dense tubular network membrane
GO:0031410 cytoplasmic vesicle
GO:0043025 neuronal cell body
GO:0043235 receptor complex
GO:0045177 apical part of cell
GO:0098554 cytoplasmic side of endoplasmic reticulum membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7t3r, PDBe:7t3r, PDBj:7t3r
PDBsum7t3r
PubMed35301323
UniProtQ14573|ITPR3_HUMAN Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3 (Gene Name=ITPR3)

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