Structure of PDB 7p2w Chain A

Receptor sequence
>7p2wA (length=204) Species: 83333 (Escherichia coli K-12) [Search protein sequence]
KGLDAVRKRPGMYIGDTDDGTGLHHMVFEVVDNAIDEALAGHCKEIIVTI
HADNSVSVQDDGRGIPTGIHPEEGVSAAEVIMTVLHAGGKFDDNSYKVGL
HGVGVSVVNALSQKLELVIQREGKIHRQIYEHGVPQAPLAVTGETEKTGT
MVRFWPSLETFTNVTEFEYEILAKRLRELSFLNSGVSIRLRDKRDGKEDH
FHYE
3D structure
PDB7p2w Discovery and Hit-to-Lead Optimization of Benzothiazole Scaffold-Based DNA Gyrase Inhibitors with Potent Activity against Acinetobacter baumannii and Pseudomonas aeruginosa.
ChainA
Resolution1.65 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 4QR A N46 E50 D73 R76 G77 I78 P79 V118 V120 R136 T165 N33 E37 D60 R63 G64 I65 P66 V103 V105 R121 T150
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
Biological Process
GO:0006265 DNA topological change

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Molecular Function
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Biological Process
External links
PDB RCSB:7p2w, PDBe:7p2w, PDBj:7p2w
PDBsum7p2w
PubMed36634346
UniProtP0AES6|GYRB_ECOLI DNA gyrase subunit B (Gene Name=gyrB)

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