Structure of PDB 5i7o Chain A

Receptor sequence
>5i7oA (length=280) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
RYDSLLQALGNTPLVGLQRLSPRWDDGRDGPHVRLWAKLEDRNPTGSIKD
RPAVRMIEQAEADGLLRPGATILEPTSGNTGISLAMAARLKGYRLICVMP
ENTSVERRQLLELYGAQIIFAVATAKELAATNPSWVMLYQYGNPANTDSH
YCGTGPELLADLPEITHFVAGLGTTGTLMGTGRFLREHVANVKIVAAEPR
VPELYDPEILTARYSVGAVDAVRRTRELVHTEGIFAGISTGAVLHAALGV
GAGALAAGERADIALVVADAGWKYLSTGAY
3D structure
PDB5i7o Inhibitors of the Cysteine Synthase CysM with Antibacterial Potency against Dormant Mycobacterium tuberculosis.
ChainA
Resolution2.49 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K51 S265
Catalytic site (residue number reindexed from 1) K49 S239
Enzyme Commision number 2.5.1.113: [CysO sulfur-carrier protein]-thiocarboxylate-dependent cysteine synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PLP A K51 N81 G182 L183 G184 T185 T186 T188 S265 A294 D295 K49 N79 G171 L172 G173 T174 T175 T177 S239 A268 D269
BS02 S16 A K51 T78 S79 N81 T82 Q151 Y152 G184 T185 A208 E209 P210 S265 K49 T76 S77 N79 T80 Q140 Y141 G173 T174 A197 E198 P199 S239 MOAD: Kd=3.4uM
Gene Ontology
Molecular Function
GO:0004124 cysteine synthase activity
GO:0005515 protein binding
GO:0016740 transferase activity
GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups
GO:0030170 pyridoxal phosphate binding
GO:0033847 O-phosphoserine sulfhydrylase activity
Biological Process
GO:0006535 cysteine biosynthetic process from serine
GO:0019344 cysteine biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0032991 protein-containing complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5i7o, PDBe:5i7o, PDBj:5i7o
PDBsum5i7o
PubMed27379713
UniProtP9WP53|CYSM_MYCTU O-phosphoserine sulfhydrylase (Gene Name=cysM)

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