Structure of PDB 1aii Chain A Binding Site BS05

Receptor Information
>1aii Chain A (length=322) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ASIWVGHRGTVRDYPDFSPSVDAEAIQKAIRGIGTDEKMLISILTERSNA
QRQLIVKEYQAAYGKELKDDLKGDLSGHFEHLMVALVTPPAVFDAKQLKK
SMKGAGTNEDALIEILTTRTSRQMKDISQAYYTVYKKSLGDDISSETSGD
FRKALLTLADGRRDESLKVDEHLAKQDAQILYKAGENRWGTDEDKFTEIL
CLRSFPQLKLTFDEYRNISQKDIVDSIKGELSGHFEDLLLAIVNCVRNTP
AFLAERLHRALKGIGTDEFTLNRIMVSRSEIDLLDIRTEFKKHYGYSLYS
AIKSDTSGDYEITLLKICGGDD
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain1aii Chain A Residue 357 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1aii Can enzymatic activity, or otherwise, be inferred from structural studies of annexin III?
Resolution1.95 Å
Binding residue
(original residue number in PDB)		M104 K105 G106 G108 E148
Binding residue
(residue number reindexed from 1)		M102 K103 G104 G106 E146
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0001786 phosphatidylserine binding
GO:0004859 phospholipase inhibitor activity
GO:0005509 calcium ion binding
GO:0005544 calcium-dependent phospholipid binding
GO:0019834 phospholipase A2 inhibitor activity
GO:0048306 calcium-dependent protein binding
Biological Process
GO:0006909 phagocytosis
GO:0010595 positive regulation of endothelial cell migration
GO:0021766 hippocampus development
GO:0031100 animal organ regeneration
GO:0042742 defense response to bacterium
GO:0043312 neutrophil degranulation
GO:0045766 positive regulation of angiogenesis
GO:0051054 positive regulation of DNA metabolic process
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0051384 response to glucocorticoid
GO:0070848 response to growth factor
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0012506 vesicle membrane
GO:0016020 membrane
GO:0030424 axon
GO:0030425 dendrite
GO:0030670 phagocytic vesicle membrane
GO:0042581 specific granule
GO:0043025 neuronal cell body
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1aii, PDBe:1aii, PDBj:1aii
PDBsum1aii
PubMed9111038
UniProtP12429|ANXA3_HUMAN Annexin A3 (Gene Name=ANXA3)

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