Structure of PDB 7bdj Chain B Binding Site BS03

Receptor Information
>7bdj Chain B (length=1722) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LAPRQVLDLEDLVFTQGSHFMANKRCQLPDGSFRRQRKGYEEVHVPALKP
KPFGSEEQLLPVEKLPKYAQAGFEGFKTLNRIQSKLYRAALETDENLLLC
APTGAGKTNVALMCMLREIGKHINMDGTINVDDFKIIYIAPMRSLVQEMV
GSFGKRLATYGITVAELTGDHQEEISATQIIVCTPEKWDIITRKGGERTY
TQLVRLIILDEIHLLHDDRGPVLEALVARAIRNIEMTQEDVRLIGLSATL
PNYEDVATFLRVDPAKGLFYFDNSFRPVPLEQTYVGITEKKAIKRFQIMN
EIVYEKIMEHAGKNQVLVFVHSRKETGKTARAIRDMCLEKDTLGLFLREG
SASTEVLRTEAEQCKNLELKDLLPYGFAIHHAGMTRVDRTLVEDLFADKH
IQVLVSTATLAWGVNLPAHTVIIKGTQVYSPEKGRWTELGALDILQMLGR
AGRPQYDTKGEGILITSHGELQYYLSLLNQQLPIESQMVSKLPDMLNAEI
VLGNVQNAKDAVNWLGYAYLYIRMLRSPTLYGISHDDLKGDPLLDQRRLD
LVHTAALMLDKNNLVKYDKKTGNFQVTELGRIASHYYITNDTVQTYNQLL
KPTLSEIELFRVFSLSSEFKNITVREEEKLELQKLLERVPIPVKESIEEP
SAKINVLLQAFISQLKLEGFALMADMVYVTQSAGRLMRAIFEIVLNRGWA
QLTDKTLNLCKMIDKRMWQSMCPLRQFRKLPEEVVKKIEKKNFPFERLYD
LNHNEIGELIRMPKMGKTIHKYVHLFPKLELSVHLQPITRSTLKVELTIT
PDFQWDEKVHGSSEAFWILVEDVDSEVILHHEYFLLKAKYAQDEHLITFF
VPVFEPLPPQYFIRVVSDRWLSCETQLPVSFRHLILPEKYPPPTELLDLQ
PLPVSALRNSAFESLYQDKFPFFNPIQTQVFNTVYNSDDNVFVGAPTGSG
KTICAEFAILRMLLQSSEGRCVYITPMEALAEQVYMDWYEKFQDRLNKKV
VLLTGETSTDLKLLGKGNIIISTPEKWDILSRRWKQRKNVQNINLFVVDE
VHLIGGENGPVLEVICSRMRYISSQIERPIRIVALSSSLSNAKDVAHWLG
CSATSTFNFHPNVRPVPLELHIQGFNISHTQTRLLSMAKPVYHAITKHSP
KKPVIVFVPSRKQTRLTAIDILTTCAADIQRQRFLHCTEKDLIPYLEKLS
DSTLKETLLNGVGYLHEGLSPMERRLVEQLFSSGAIQVVVASRSLCWGMN
VAAHLVIIMDTQYYNGKIHAYVDYPIYDVLQMVGHANRPLQDDEGRCVIM
CQGSKKDFFKKFLYEPLPVESHLDHCMHDHFNAEIVTKTIENKQDAVDYL
TWTFLYRRMTQNPNYYNLQGISHRHLSDHLSELVEQTLSDLEQSKCISIE
DEMDVAPLNLGMIAAYYYINYTTIELFSMSLNAKTKVRGLIEIISNAAEY
ENIPIRHHEDNLLRQLAQKVPHKLNNPKFNDPHVKTNLLLQAHLSRMQLS
AELQSDTEEILSKAIRLIQACVDVLSSNGWLSPALAAMELAQMVTQAMWS
KDSYLKQLPHFTSEHIKRCTDKGVESVFDIMEMEDEERNALLQLTDSQIA
DVARFCNRYPNIELSYEVVDKDSIRSGGPVVVLVQLEREEEVTGPVIAPL
FPQKREEGWWVVIGDAKSNSLISIKRLTLQQKAKVKLDFVAPATGAHNYT
LYFMSDAYMGCDQEYKFSVDVK
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain7bdj Chain B Residue 2203 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7bdj Long-range allostery mediates cooperative adenine nucleotide binding by the Ski2-like RNA helicase Brr2.
Resolution2.59 Å
Binding residue
(original residue number in PDB)		K509 D615 E616
Binding residue
(residue number reindexed from 1)		K107 D210 E211
Annotation score1
Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:7bdj, PDBe:7bdj, PDBj:7bdj
PDBsum7bdj
PubMed34048711
UniProtO75643|U520_HUMAN U5 small nuclear ribonucleoprotein 200 kDa helicase (Gene Name=SNRNP200)

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