Structure of PDB 8j9w Chain A Binding Site BS03

Receptor Information
>8j9w Chain A (length=775) Species: 10497 (African swine fever virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
YTRARNAGGKRAQDCMLLAAEGDSALSLLRTGLTLGKSNPSGPSFDFCGM
ISLGGVIMNACKKVTNITTDSGETIMVRNEQLTNNKVLQGIVQVLGLDFN
CHYKTQEERAKLRYGCIVACVDQDLDGCGKILGLLLAYFHLFWPQLIIHG
FVKRLLTPLIRVYEKGKTMPVEFYYEQEFDAWAKKQTSLVNHTVKYYKGL
AAHDTHEVKSMFKHFDNMVYTFTLDDSAKELFHIYFGGESELRKRELCTG
VVPLTETQTQSIHSVRRIPCSLHLQVDTKAYKLDAIERQIPNFLDGMTRA
RRKILAGGVKCFASNNRERKVFQFGGYVADHMFYHHGDMSLNTSIIKAAQ
YYPGSSHLYPVFIGIGSFGSRHLGGKDAGSPRYISVQLASEFIKTMFPAE
DSWLLPYVFEDGQRAEPEYYVPVLPLAIMEYGANPSEGWKYTTWARQLED
ILALVRAYVDKDNPKHELLHYAIKHKITILPLRPSNYNFKGHLKRFGQYY
YSYGTYDISEQRNIITITELPLRVPTVAYIESIKKSSNRMTFIEEIIDYS
SSETIEILVKLKPNSLNRIVEEFKETEEQDSIENFLRLRNCLHSHLNFVK
PKGGIIEFNSYYEILYAWLPYRRELYQKRLMREHAVLKLRIIMETAIVRY
INESAELNLSHYEDEKEASRILSEHGFPPLNHTLIISPEFASIEELNQKA
LQGCYTYILSLQARELLIAAKTRRVEKIKKMQARLDKVEQLLQESPFPGA
SVWLEEIDAVEKAIIKGRNTQWKFH
Ligand information
Receptor-Ligand Complex Structure
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PDB8j9w Cryo-EM structure of the African swine fever virus topoisomerase 2 complexed with Cut02bDNA and etoposide (EDI-2)
Resolution2.76 Å
Binding residue
(original residue number in PDB)		D440 M756
Binding residue
(residue number reindexed from 1)		D23 M339
Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003916 DNA topoisomerase activity
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
GO:0046872 metal ion binding
Biological Process
GO:0000819 sister chromatid segregation
GO:0006259 DNA metabolic process
GO:0006265 DNA topological change
Cellular Component
GO:0030430 host cell cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8j9w, PDBe:8j9w, PDBj:8j9w
PDBsum8j9w
PubMed38418525
UniProtQ00942|TOP2_ASFB7 DNA topoisomerase 2 (Gene Name=TOP)

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