Structure of PDB 1nrn Chain H Binding Site BS02

Receptor Information
>1nrn Chain H (length=247) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKEKGQP
SVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGG
PFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVI
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1nrn Crystallographic structures of thrombin complexed with thrombin receptor peptides: existence of expected and novel binding modes.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		H57 Y60A W60D R173 I174 E192 W215 G216 E217 G219
Binding residue
(residue number reindexed from 1)		H43 Y47 W50 R171 I172 E195 W220 G221 E222 G223
Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:1nrn, PDBe:1nrn, PDBj:1nrn
PDBsum1nrn
PubMed8136362
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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