BioLiP

Receptor Information

>7xd9 Chain D (length=622) Species: 11060 (dengue virus type 2) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

ESETPNLDIIGKRIEKIKQEHETSWHYDQDHPYKTWAYHGSYETKQTGSA
SSMVNGVVRLLTKPWDIIPMVTQMAMTDTTPFGQQRVFKEKVDTRTQEPK
EGTKKLMKITAEWLWKELGKKKTPRMCTREEFTRKVRSNAALGAIFTDEN
KWKSAREAVEDSGFWELVDKERNLHLEGKCETCVYNMMGKREKKLGEFGK
AKGSRAIWYMWLGARFLEFEALGFLNEDHWFSRENSLSGVEGEGLHKLGY
ILRDVSKKEGGAMYADDTAGWDTRITLEDLKNEEMVTNHMEGEHKKLAEA
IFKLTYQNKVVRVQRPTPRGTVMDIISRRDQRGSGQVVTYGLNTFTNMEA
QLIRQMEGEGVFKSIQHLTVTEEIAVKNWLVRVGRERLSRMAISGDDCVV
KPLDDRFASALTALNDMGKVRKDIQQWEPSRGWNDWTQVPFCSHHFHELI
MKDGRVLVVPCRNQDELIGRARISQGAGWSLRETACLGKSYAQMWSLMYF
HRRDLRLAANAICSAVPSHWVPTSRTTWSIHATHEWMTTEDMLTVWNRVW
IQENPWMEDKTPVESWEEIPYLGKREDQWCGSLIGLTSRATWAKNIQTAI
NQVRSLIGNEEYTDYMPSMKRF

Receptor-Ligand Complex Structure

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Structure summary

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PDB	7xd9 Structural basis of transition from initiation to elongation in de novo viral RNA-dependent RNA polymerases.
Resolution	2.58 Å
Binding residue (original residue number in PDB)	R404 S405 S661 G662 D663 D664 C709 S710 R729 L754 Y758 M761 T790 S791 R792
Binding residue (residue number reindexed from 1)	R137 S138 S394 G395 D396 D397 C442 S443 R462 L487 Y491 M494 T523 S524 R525

Enzyme Commision number

3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.

	Molecular Function
GO:0003968	RNA-dependent RNA polymerase activity
GO:0005524	ATP binding

	Biological Process
GO:0039694	viral RNA genome replication

PDB	RCSB:7xd9, PDBe:7xd9, PDBj:7xd9
PDBsum	7xd9
PubMed	36577062
UniProt	Q91H74

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Structure of PDB 7xd9 Chain D Binding Site BS02