Structure of PDB 4emt Chain B Binding Site BS02
Receptor Information
>4emt Chain B (length=175) Species:
9606
(Homo sapiens) [
Search protein sequence
] [
Download receptor structure
] [
Download structure with residue number starting from 1
] [
View receptor structure
]
SVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLP
LDCGVPDNLSMADPNIRFLDKLPQDRVYSNSIYELLENGQRAGTCVLEYA
TPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRLI
AYQEPADDSSFSLSQEVLRHLRQEE
Ligand information
Ligand ID
CA
InChI
InChI=1S/Ca/q+2
InChIKey
BHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
Software
SMILES
CACTVS 3.341
[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0
[Ca+2]
Formula
Ca
Name
CALCIUM ION
ChEMBL
DrugBank
DB14577
ZINC
PDB chain
4emt Chain B Residue 401 [
Download ligand structure
] [
Download structure with residue number starting from 1
] [
View ligand structure
]
Receptor-Ligand Complex Structure
Global view
Local view
Structure summary
[
Spin on
] [
Spin off
] [
Reset
]
[
High quality
] [
Low quality
]
[
White background
] [
Black background
]
[
Spin on
] [
Spin off
] [
Reset
]
[
High quality
] [
Low quality
]
[
White background
] [
Black background
]
PDB
4emt
Structure of STING bound to cyclic di-GMP reveals the mechanism of cyclic dinucleotide recognition by the immune system.
Resolution
1.5 Å
Binding residue
(original residue number in PDB)
A318 D320
Binding residue
(residue number reindexed from 1)
A156 D158
Annotation score
1
Binding affinity
Manual survey: Kd=5uM (22728658)
Enzymatic activity
Enzyme Commision number
?
Gene Ontology
Biological Process
GO:0002218
activation of innate immune response
GO:0032481
positive regulation of type I interferon production
View graph for
Biological Process
External links
PDB
RCSB:4emt
,
PDBe:4emt
,
PDBj:4emt
PDBsum
4emt
PubMed
22728658
UniProt
Q86WV6
|STING_HUMAN Stimulator of interferon genes protein (Gene Name=STING1)
[
Back to BioLiP
]