Structure of PDB 1m8w Chain B Binding Site BS02
Receptor Information
>1m8w Chain B (length=341) Species:
9606
(Homo sapiens) [
Search protein sequence
] [
Download receptor structure
] [
Download structure with residue number starting from 1
] [
View receptor structure
]
GRSRLLEDFRNNRYPNLQLREIAGHIMEFSQDQHGSRFIQLKLERATPAE
RQLVFNEILQAAYQLMVDVFGNYVIQKFFEFGSLEQKLALAERIRGHVLS
LALQMYGCRVIQKALEFIPSDQQNEMVRELDGHVLKCVKDQNGNHVVQKC
IECVQPQSLQFIIDAFKGQVFALSTHPYGCRVIQRILEHCLPDQTLPILE
ELHQHTEQLVQDQYGNYVIQHVLEHGRPEDKSKIVAEIRGNVLVLSQHKF
ASNVVEKCVTHASRTERAVLIDEVCTMNDGPHSALYTMMKDQYANYVVQK
MIDVAEPGQRKIVMHKIRPHIATLRKYTYGKHILAKLEKYY
Ligand information
>1m8w Chain F (length=7) [
Search RNA sequence
] [
Download ligand structure
] [
Download structure with residue number starting from 1
] [
View ligand structure
]
uguccag
.......
Receptor-Ligand Complex Structure
Global view
Local view
Structure summary
[
Spin on
] [
Spin off
] [
Reset
]
[
High quality
] [
Low quality
]
[
White background
] [
Black background
]
[
Spin on
] [
Spin off
] [
Reset
]
[
High quality
] [
Low quality
]
[
White background
] [
Black background
]
PDB
1m8w
MODULAR RECOGNITION OF RNA BY A HUMAN PUMILIO-HOMOLOGY DOMAIN
Resolution
2.2 Å
Binding residue
(original residue number in PDB)
Y900 R936 Q939 H972 R1008 Y1041 N1043 Y1044 Q1047 F1077 S1079 N1080 E1083 Y1120 N1122 Y1123 Y1156 H1159
Binding residue
(residue number reindexed from 1)
Y73 R109 Q112 H145 R181 Y214 N216 Y217 Q220 F250 S252 N253 E256 Y293 N295 Y296 Y329 H332
Binding affinity
PDBbind-CN
: Kd=500nM
Enzymatic activity
Enzyme Commision number
?
Gene Ontology
Molecular Function
GO:0003723
RNA binding
View graph for
Molecular Function
External links
PDB
RCSB:1m8w
,
PDBe:1m8w
,
PDBj:1m8w
PDBsum
1m8w
PubMed
12202039
UniProt
Q14671
|PUM1_HUMAN Pumilio homolog 1 (Gene Name=PUM1)
[
Back to BioLiP
]