Structure of PDB 8jc5 Chain A Binding Site BS02

Receptor Information
>8jc5 Chain A (length=164) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KEEMELTLVGLQYSGKTTFVNVIASGQFSEDMIPTVGFNMRKVTKGNVTI
KIWDIGGLPRFRSMWERYCRGVNAIVYMIDAADREKIEASRNELHNLLDK
PQLQGIPVLVLGNKRDLPNALDEKQLIEKMNLSAIQDREICCYSISCKEK
DNIDITLQWLIQHS
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain8jc5 Chain A Residue 202 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8jc5 Mechanistic Insights into the Interactions of Arl8b with the RUN Domains of PLEKHM1 and SKIP.
Resolution2.01 Å
Binding residue
(original residue number in PDB)		T34 T52
Binding residue
(residue number reindexed from 1)		T17 T35
Annotation score1
Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0003925 G protein activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0016787 hydrolase activity
GO:0019003 GDP binding
GO:0043014 alpha-tubulin binding
GO:0048487 beta-tubulin binding
Biological Process
GO:0001778 plasma membrane repair
GO:0002505 antigen processing and presentation of polysaccharide antigen via MHC class II
GO:0002747 antigen processing and presentation following phagocytosis
GO:0007059 chromosome segregation
GO:0008089 anterograde axonal transport
GO:0015031 protein transport
GO:0016197 endosomal transport
GO:0032418 lysosome localization
GO:0034498 early endosome to Golgi transport
GO:0042267 natural killer cell mediated cytotoxicity
GO:0046754 viral exocytosis
GO:0051301 cell division
GO:0061909 autophagosome-lysosome fusion
GO:0090117 endosome to lysosome transport of low-density lipoprotein particle
GO:0090385 phagosome-lysosome fusion
GO:1902774 late endosome to lysosome transport
GO:1902946 protein localization to early endosome
GO:1990927 calcium ion regulated lysosome exocytosis
Cellular Component
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005768 endosome
GO:0005819 spindle
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0016020 membrane
GO:0030424 axon
GO:0030496 midbody
GO:0031901 early endosome membrane
GO:0031902 late endosome membrane
GO:0042995 cell projection
GO:0045202 synapse
GO:0051233 spindle midzone
GO:0070062 extracellular exosome
GO:0101004 cytolytic granule membrane
GO:1904115 axon cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8jc5, PDBe:8jc5, PDBj:8jc5
PDBsum8jc5
PubMed37775038
UniProtQ9NVJ2|ARL8B_HUMAN ADP-ribosylation factor-like protein 8B (Gene Name=ARL8B)

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