Structure of PDB 8asg Chain A Binding Site BS02

Receptor Information
>8asg Chain A (length=1544) Species: 992210 (SFTS virus AH12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MNLEVLCGRINVENGLSLGEPGLYDQIYDRPGLPDLDVTVDATGVTVDIG
AVPDSASQLGSSINAGLITIQLSEAYKINHDFTFSGLRRLSEVFPITHDG
SDGMTPAVIHTRLDGTIVVVEFSTTRSHNIGGLEAAYRTKIEKYRDPISR
RVDIMENPRVFFGVIVVSSGGVLSNMPLTQDEAEELMYRFCIANEIYTKA
RSMDADIELQKSEEELEAISRALSFFSLFEPNIERVEGTFPNSEIKMLEQ
FLSTPADVDFITKTLKAKEVEAYADLCDSHYLKPEKTIQERLEINRCEAI
DKTQDLLAGLHARSNKQTSLNRGTVKLPPWLPKPSSESIDIKTDSGFGSL
MDHGAYGELWAKCLLDVSLGNVEGVVSDPAKELDIAISDDPEKDTPKEAK
ITYRRFKPALSSSARQEFSLQGVEGKKWKRMAANQKKEKESHETLSPFLD
VEDIGDFLTFNNLLTDSRYGDESIQRAVSILLEKASAMQDTELTHALNDS
FKRNLSSNVVQWSLWVSCLAQELASALKQHCRAGEFIIKKLKFWPIYVII
KPTKSSSHIFYSLGIRKADVTRRLTGRVFSDTIDAGEWELTEFKSLKTCK
LTNLVNLPCTMLNSIAFWREKLGVAPWLVRKPCSELREQVGLTFLISLED
KSKTEEIITLTRYTQMEGFVSPPMLPKPQKMLGKLDGPLRTKLQVYLLRK
HLDCMVRIASQPFSLIPREGRVEWGGTFHAISGRSTNLENMVNSWYIGYY
KNKEESTELNALGEMYKKIVEMEEDKPSSPEFLGWGDTDSPKKHEFSRSF
LRAACSSLEREIAQRHGRQWKQNLEERVLREIGTKNILDLASMKATSNFS
KDWELYSEVQTKEYHRSKLLEKMATLIEKGVMWYIDAVGQAWKAVLDDGC
MRICLFKKNQHREIYVMDANARLVQFGVETMARCVCELSPHETVANPRLK
NSIIENHGLKSARSLGPGSININSSNDAKKWNQGHYTTKLALVLCWFMPA
KFHRFIWAAISMFRRKKMMVDLRFLAHLSSKSESRSSDPFREAMTDAFHG
NRDVSWMDKGRTYIKTETGMMQGILHFTSSLLHSCVQSFYKSYFVSKLKE
GYMGESISGVVDVIEGSDDSAIMISIRPKSDMDEVRSRFFVANLLHSVKF
LNPLFGIYSSEKSTVNTVYCVEYNSEFHFHRHLVRPTLRWIAASHQISET
EALASRQEDYSNLLTQCLEGGASFSLTYLIQCAQLLHHYMLLGLCLHPLF
GTFMGMLISDPDPALGFFLMDNPAFAGGAGFRFNLWRACKTTDLGRKYAY
YFNEIQGHSVMVYWGDRKKYQALLNRMGLPEDWVEQIDENPGVLYRRAAN
KKELLLKLAEKVHSPGVTSSLSKGHVVPRVVAAGVYLLSRHCFRFSGSTQ
KASLIKLLMMSSISAMKHGGSLNPNQERMLFPQAQEYDRVCTLLEEVEHL
TGKFVVRERNIVRSRIDLFAEDLVSEVWFGEWDKLRASFAWLSTDPSETL
RDGPFLSHVQFRNFIAHRSVRLLGAPVTISQVVRMNFFPGFSLE
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8asg Structural insights into viral genome replication by the severe fever with thrombocytopenia syndrome virus L protein.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		R318 K331 G430 K431 K442 E443 S446 H447 T558 F565 S600 K602 K605 K656 R695 E763 L764 N765 H1035 L1036 R1043 S1045 R1049 T1053
Binding residue
(residue number reindexed from 1)		R313 K326 G425 K426 K437 E438 S441 H442 T553 F560 S595 K597 K600 K651 R690 E758 L759 N760 H1027 L1028 R1035 S1037 R1041 T1045
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0003968 RNA-dependent RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0001172 RNA-templated transcription
GO:0006351 DNA-templated transcription
GO:0019079 viral genome replication
GO:0039694 viral RNA genome replication
Cellular Component
GO:0044165 host cell endoplasmic reticulum
GO:0044172 host cell endoplasmic reticulum-Golgi intermediate compartment
GO:0044177 host cell Golgi apparatus
GO:0044423 virion component

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8asg, PDBe:8asg, PDBj:8asg
PDBsum8asg
PubMed36651274
UniProtU3GU88

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