Structure of PDB 4zks Chain U Binding Site BS01

Receptor Information
>4zks Chain U (length=246) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IIGGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVISATHCFID
YPKKEDYIVYLGRSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIAL
LKIRSKEGRCAQPSRTIQTIALPSMYNDPQFGTSCEITGFGKEQSTDYLY
PEQLKMTVVKLISHRECQQPHYYGSEVTTKMLCAADPQWKTDSCQGDAGG
PLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWIRSHTK
Ligand information
Receptor-Ligand Complex Structure
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PDB4zks The crystal structure of mupain-1-IG in complex with murinised human uPA at pH7.4
Resolution1.85 Å
Binding residue
(original residue number in PDB)		R35 V41 C42 H57 C58 D60A Y60B H99 D189 S190 Q192 G193 A195 W215 G226
Binding residue
(residue number reindexed from 1)		R20 V30 C31 H46 C47 D50 Y51 H94 D192 S193 Q195 G196 A198 W218 G229
Enzymatic activity
Enzyme Commision number 3.4.21.73: u-plasminogen activator.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:4zks, PDBe:4zks, PDBj:4zks
PDBsum4zks
PubMed
UniProtP00749|UROK_HUMAN Urokinase-type plasminogen activator (Gene Name=PLAU)

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