Structure of PDB 5hl7 Chain S Binding Site BS01

Receptor Information
>5hl7 Chain S (length=167) Species: 93061 (Staphylococcus aureus subsp. aureus NCTC 8325) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SLKSIIRQGKQTRSDLKQLRKSGKVPAVVYGYGTKNVSVKVDEVEFIKVI
REVGRNGVIELGVGSKTIKVMVADYQFDPLKNQITHIDFLAINMSEERTV
EVPVQLVGEAVGAKEGGVVEQPLFNLEVTATPDNIPEAIEVDITELNIND
SLTVADVKVTGDFKIEN
Ligand information
>5hl7 Chain Y (length=114) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ucuggugacuauagcaaggaggucacaccuguucccaugccgaacacaga
aguuaaggucuuuagcgacgaugguagccaacuuacguuccgcuagagua
gaacguugccaggc
.<<.<..<.....<<<<<<<......<<<<<...............>>>.
.>>.....>>>>>.>><....<....<.<............>.>.....>
...>..>..>.>>.
Receptor-Ligand Complex Structure
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PDB5hl7 A novel pleuromutilin antibacterial compound, its binding mode and selectivity mechanism.
Resolution3.55 Å
Binding residue
(original residue number in PDB)		D17 L18 K19 R22 V30 Y32 N38 Q78 H88
Binding residue
(residue number reindexed from 1)		D15 L16 K17 R20 V28 Y30 N36 Q76 H86
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0008097 5S rRNA binding
GO:0019843 rRNA binding
Biological Process
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5hl7, PDBe:5hl7, PDBj:5hl7
PDBsum5hl7
PubMed27958389
UniProtQ2G0S0

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