BioLiP

Receptor Information

>6sv4 Chain Oc (length=313) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

LVLRGTLEGHNGWVTSLATSAGQPNLLLSASRDKTLISWKLTGDDQKFGV
PVRSFKGHSHIVQDCTLTADGAYALSASWDKTLRLWDVATGETYQRFVGH
KSDVMSVDIDKKASMIISGSRDKTIKVWTIKGQCLATLLGHNDWVSQVRV
VPNEKADDDSVTIISAGNDKMVKAWNLNQFQIEADFIGHNSNINTLTASP
DGTLIASAGKDGEIMLWNLAAKKAMYTLSAQDEVFSLAFSPNRYWLAAAT
ATGIKVFSLDPQYLVDDLRPEFAGYSKAAEPHAVSLAWSADGQTLFAGYT
DNVIRVWQVMTAN

>6sv4 Chain 2c (length=1758) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

uaucugguugauccugccaguagucauaugcuugucucaaagauuaagcc
augcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcuca
uuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacu
gugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaaga
gauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauuc
auaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaa
auuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuu
caacggguaacggggaauaaggguucgauuccggagagggagccugagaa
acggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccu
aauucagggagguagugacaauaaauaacgauacagggcccauucggguc
uuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauugga
gggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguau
auuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguu
ggccggucggauuuccaacggggccuuuccuucuggcuaaccuugagucc
uuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguu
caaagcaggcguauugcucgaauauauuagcauggaauaauagaauagga
cguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagg
gacggucgggggcaucaguauucaauugucagaggugaaauucuuggauu
uauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaa
ucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucu
uaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacc
cacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguau
ggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggag
uggagccugcggcuuaauuugacucaacacggggaaacucaccaggucca
gacacaauaaggauugacagauugagagcucuuucuugauuuugugggug
guggugcauggccguucuuaguugguggagugauuugucugcuuaauugc
gauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcug
guuauccacuucuuagagggacuaucgguuucaagccgauggaaguuuga
ggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgc
uacacugacggagccagcgagucuaaccuuggccgagaggucuugguaau
cuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuu
caacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgu
cccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuua
gugaggccucaggaucugcagagcggagaauuuggacaaacuuggucauu
uagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaag
gaucauua

...<<<<<...[[[[>>>>>[[[..((((((................[[[
.[[[..<<....<<....<<..........>>...>>.>>......{{..
......[[[..{{........[[[..................<.....<<
.............>>......>.........<<<<<..<<....>>..>>
>>>....((((((......<<<<<<<<<<<<..>>>>.............
.)))))).........<<<<..<<<.....>>>.>>>>....]]].....
}}..]]].<<<....<<.....<<<<<<<<.......>>>>>>>>.>>..
....>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<.......
...>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<
.....>>>..>>>...............<<<<<.<<<<<.......>.>>
>>.>>.>>>......<<.................>>.........<<<<<
((....<.<<<<.....<<..))>>.......>>>>>>>>>>..))))))
.]]].........[[[{{.......{{...[[[.{{.....<<<<<.<<<
<<............>>>>>.>>>>>.....<<<<<<..............
.................>>>>>>...<<<<<.<<.......<<...<...
....>..<<<.....>>>....>>......>>.>>..>>>.........[
[[..(((((((.....>>>>>>>>..))))))).]]].....}}....<<
<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>
.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]
]...}}......<<<<<<<...<...<<<<.........>>>>...>>>>
>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>
>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......
<<<<....>>>>....>>>..]]]]..<<<<..<<<<<<<..<<.<<<<<
<..<<<.<<<<<.......<<........>>..........<<<<<.<..
..<<<<<........<<.<<<........>>>.>>......>>>>>...<
<.<<<..<<<<<<<<<....<<<.<<<<......>>...<<<......>>
>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>
>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>
>>....>>>.>>>...>.>>>>>>>.....>.>>>>>....>.>>>>.>>
>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....
>>.......>>>>>>>......<....<<<<<<..........>>>>>>.
...>.....>>>>>>....<<<<<<<<.......>>>>>>>>......>>
...>>>>>>>.>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<
<<..<.<<..<...<<<<<...>>>>>...>..>>.>..>>>.>>>>>>>
>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>.
........

Receptor-Ligand Complex Structure

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Structure summary

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PDB	6sv4 RQT complex dissociates ribosomes collided on endogenous RQC substrate SDD1.
Resolution	3.3 Å
Binding residue (original residue number in PDB)	G63 S282
Binding residue (residue number reindexed from 1)	G57 S276

Enzyme Commision number

	Molecular Function
GO:0001965	G-protein alpha-subunit binding
GO:0005080	protein kinase C binding
GO:0005092	GDP-dissociation inhibitor activity
GO:0043022	ribosome binding
GO:0045182	translation regulator activity

	Biological Process
GO:0002181	cytoplasmic translation
GO:0006521	regulation of cellular amino acid metabolic process
GO:0007186	G protein-coupled receptor signaling pathway
GO:0010629	negative regulation of gene expression
GO:0017148	negative regulation of translation
GO:0061157	mRNA destabilization
GO:0070651	nonfunctional rRNA decay
GO:0072344	rescue of stalled ribosome
GO:1902660	negative regulation of glucose mediated signaling pathway
GO:1990116	ribosome-associated ubiquitin-dependent protein catabolic process
GO:1990145	maintenance of translational fidelity
GO:2001125	negative regulation of translational frameshifting

	Cellular Component
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0022627	cytosolic small ribosomal subunit
GO:1990904	ribonucleoprotein complex

PDB	RCSB:6sv4, PDBe:6sv4, PDBj:6sv4
PDBsum	6sv4
PubMed	32203490
UniProt	P38011\|GBLP_YEAST Small ribosomal subunit protein RACK1 (Gene Name=ASC1)

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Structure of PDB 6sv4 Chain Oc Binding Site BS01