Structure of PDB 7x8x Chain O Binding Site BS01
Receptor Information
>7x8x Chain O (length=194) Species:
83331
(Mycobacterium tuberculosis CDC1551) [
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ILPSFIEHSSFGVKESNPYNKLFEERIIFLGVQVDDASANDIMAQLLVLE
SLDPDRDITMYINSPGGGFTSLMAIYDTMQYVRADIQTVCLGQAASAAAV
LLAAGTPGKRMALPNARVLIHQPSLSGVIQGQFSDLEIQAAEIERMRTLM
ETTLARHTGKDAGVIRKDTDRDKILTAEEAKDYGIIDTVLEYRK
Ligand information
>7x8x Chain u (length=3) Species:
32630
(synthetic construct) [
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cLL
Receptor-Ligand Complex Structure
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PDB
7x8x
structural insights into Mycobacterium tuberculosis ClpP1P2 inhibition by Cediranib: implications for developing antimicrobial agents targeting Clp protease
Resolution
3.24 Å
Binding residue
(original residue number in PDB)
F83 S110 P137 S138
Binding residue
(residue number reindexed from 1)
F69 S96 P123 S124
Enzymatic activity
Enzyme Commision number
3.4.21.92
: endopeptidase Clp.
Gene Ontology
Molecular Function
GO:0004176
ATP-dependent peptidase activity
GO:0004252
serine-type endopeptidase activity
GO:0005515
protein binding
GO:0008236
serine-type peptidase activity
GO:0051117
ATPase binding
Biological Process
GO:0006508
proteolysis
GO:0006515
protein quality control for misfolded or incompletely synthesized proteins
Cellular Component
GO:0005737
cytoplasm
GO:0005829
cytosol
GO:0005886
plasma membrane
GO:0009274
peptidoglycan-based cell wall
GO:0009368
endopeptidase Clp complex
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Molecular Function
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Biological Process
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Cellular Component
External links
PDB
RCSB:7x8x
,
PDBe:7x8x
,
PDBj:7x8x
PDBsum
7x8x
PubMed
UniProt
P9WPC3
|CLPP2_MYCTU ATP-dependent Clp protease proteolytic subunit 2 (Gene Name=clpP2)
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