Structure of PDB 4oga Chain E Binding Site BS01

Receptor Information
>4oga Chain E (length=288) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GEVCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLSFPKL
IMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVHLKEL
GLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNHIVLNKDDNEE
CGDICNCPATVINGQFVERCWTHSHCQKVCPTICKSHGCTAEGLCCHSEC
LGNCSQPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVNFSFCQDL
HHKQYVIHNNKCIPECPSGYTMNSSNLLCTPCLGPCPK
Ligand information
>4oga Chain B (length=21) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
CGSHLVEALYLVCGERGFFYT
Receptor-Ligand Complex Structure
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PDB4oga Protective hinge in insulin opens to enable its receptor engagement.
Resolution3.5 Å
Binding residue
(original residue number in PDB)		D12 R14 N15 L37 F39 K40
Binding residue
(residue number reindexed from 1)		D8 R10 N11 L33 F35 K36
Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
External links
PDB RCSB:4oga, PDBe:4oga, PDBj:4oga
PDBsum4oga
PubMed25092300
UniProtP06213|INSR_HUMAN Insulin receptor (Gene Name=INSR)

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