Structure of PDB 8v4x Chain C Binding Site BS01

Receptor Information
>8v4x Chain C (length=361) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QPLAKDKVALLIGNMNYREHPKLKAPLVDVYELTNLLRQLDFKVVSLLDL
TEYEMRNAVDEFLLLLDKGVYGLLYYAGHGYENFGNSFMVPVDAPNPYRS
ENCLCVQNILKLMQEKETGLNVFLLDMCRKRNDYDDTIPILDALKVTANI
VFGYATCQGAEAFEIQHSGLANGIFMKFLKDRLLEDKKITVLLDEVAEDM
GKCHLTKGKQALEIRSSLSEKRALTDPIQGTEYSAESLVRNLQWAKAHEL
PESMCLKIQLGFAAEFSNVMIIYTSIVPEIIMCDAYVTDFPLDLDIDPKD
ANKGTPEETGSYLHCLYTRLSSLQKLKEHLVFTVCLSYQYLEDTVEDKQE
VNVGKPLIAKL
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8v4x Inhibition of MALT1 and BCL2 induces synergistic anti-tumor activity in models of B cell lymphoma.
Resolution2.486 Å
Binding residue
(original residue number in PDB)		L359 D365 A413 H415 D462 C464 E497 A498 F499 E500 I501 Q502 H503 L541 K545
Binding residue
(residue number reindexed from 1)		L23 D29 A77 H79 D126 C128 E161 A162 F163 E164 I165 Q166 H167 L205 K209
Enzymatic activity
Enzyme Commision number 3.4.22.-
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:8v4x, PDBe:8v4x, PDBj:8v4x
PDBsum8v4x
PubMed38507740
UniProtQ9UDY8|MALT1_HUMAN Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (Gene Name=MALT1)

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