Structure of PDB 5a08 Chain B Binding Site BS01

Receptor Information

>5a08 Chain B (length=387) Species: 559292 (Saccharomyces cerevisiae S288C)

HDAEVLDSIMDRLHEPLYEKDTFDPNEVLAENKQLYEEFLLQEISEPKVD
NLVRSGDPLAGKAKGTILSLVRNSDLEDIISSIQQLEEEYNKNFGYPYTF
LNDEEFTDEFKDGIKSILPKDRVVEFGTIGPDNWNMPDSIDRERYDQEMD
KMSEVESYHNMCRFYSKEFYHHPLLSKYKYVWRLEPNVNFYCKINYDVFQ
FMNKNDKIYGFVLNLYDSPQTIETLWTSTMDFVEEHPNYLNVNGAFAWLK
DNSQNPKNYDYTQGYSTCHFWTNFEIVDLDFLRSEPYEKYMQYLEEKGGF
YYERWGDAPVRSLALALFADKSSIHWFRDIGYHHTPYTNCPTCPADSDRC
NGNCVPGKFTPWSDLDNQNCQATWIRHSMSEEELEMY

Ligand information

• Ligand ID: CA
• InChI: InChI=1S/Ca/q+2
• InChIKey: BHPQYMZQTOCNFJ-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Ca++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Ca+2]
• Formula: Ca
• Name: CALCIUM ION
• DrugBank: DB14577
• PDB chain: 5a08 Chain B Residue 1466

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5a08 Structure of the Glycosyltransferase Ktr4P from Saccharomyces Cerevisiae
• Resolution: 2.21 Å
• Binding residue (original residue number in PDB): D77 D81
• Binding residue (residue number reindexed from 1): D7 D11
• Annotation score: 4

Enzymatic activity

• Enzyme Commision number: 2.4.1.-

Gene Ontology

Molecular Function

• GO:0000026 alpha-1,2-mannosyltransferase activity
• GO:0000030 mannosyltransferase activity
• GO:0016757 glycosyltransferase activity

Biological Process

• GO:0000032 cell wall mannoprotein biosynthetic process
• GO:0006486 protein glycosylation
• GO:0006487 protein N-linked glycosylation
• GO:0006493 protein O-linked glycosylation
• GO:0097502 mannosylation

Cellular Component

• GO:0000324 fungal-type vacuole
• GO:0005794 Golgi apparatus
• GO:0016020 membrane

External links

• PDB: RCSB:5a08, PDBe:5a08, PDBj:5a08
• PDBsum: 5a08
• PubMed: 26296208
• UniProt: P38131|KTR4_YEAST Probable mannosyltransferase KTR4 (Gene Name=KTR4)