Structure of PDB 6xu8 Chain AG Binding Site BS01

Receptor Information
>6xu8 Chain AG (length=231) Species: 7227 (Drosophila melanogaster) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MKLNVSYPATGCQKLFEVVDEHKLRVFYEKRMGQVVEADILGDEWKGYQL
RIAGGNDKQGFPMKQGVLTHGRVRLLLKKGHSCYRPRRTGERKRKSVRGC
IVDANMSVLALVVLKKGEKDIPGLTDTTIPRRLGPKRASKIRKLYNLSKE
DDVRRFVVRRPLPAKDNKKATSKAPKIQRLITPVVLQRKHRRIALKKKRQ
IASKEASADYAKLLVQRKKESKAKREEAKRR
Ligand information
>6xu8 Chain B2 (length=1936) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
auucugguugauccugccaguaguuauaugcuugucucaaagauuaagcc
augcaugucuaaguacacacgaauuaaaagugaaaccgcaaaaggcucau
uauaucaguuaugguuccuuagaucguuaacaguuacuuggauaacugug
guaauucuagagcuaauacaugcaauuaaaacaugaaccuuaugggacgu
gugcuuuuauuaggcuaaaaccaagcgaucgcaagaucguuauauugguu
gaacucuagauaacaugcagaucguauggucuuguaccgacgacagaucu
uucaaaugucugcccuaucaacuuuugaugguaguaucuaggacuaccau
gguugcaacggguaacggggaaucaggguucgauuccggagagggagccu
gagaaacggcuaccacaucuaaggaaggcagcaggcgcguaaauuaccca
cucccagcucggggagguagugacgaaaaauaacaauacaggacucauau
ccgaggcccuguaauuggaaugaguacacuuuaaauccuuuaacaaggac
caauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaa
uagcguauauuaaaguuguugcgguuaaaacguucguaguugaacuugug
cuucauacggguaguauacuauaccuuuauguauguaagcguauuaccgg
uggaguucuuauaugugaucauauguuccuccuauuuaaaaaccugcauu
agugcucuuaaacgaguguuauugugggccgguacuauuacuuugaacaa
auuagagugcuuaaagcaggcuucaaaugccugaauauucugugcauggg
auaaugaaauaagaccucuguucugcuuucauugguuuucagaucaagag
guaaugauuaauagaagcaguuugggggcauuaguauuacgacgcgagag
gugaaauucuuggaccgucguaagacuaacuuaagcgaaagcauuugcca
aagauguuuucauuaaucaagaacgaaaguuagagguucgaaggcgauca
gauaccgcccuaguucuaaccauaaacgaugccagcuagcaauugggugu
agcuacuuuuauggcucucucagucgcuuccgggaaaccaaagcuuuuug
ggcuccgggggaaguaugguugcaaagcugaaacuuaaaggaauugacgg
aagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggg
aaaacuuaccaggucgaacauaaguguguaagacagauugauagcucuuu
cucgaaucuaugggugguggugcauggccguucuuaguucguggagugau
uugucugguuaauuccgauaacgaacgagacucaaauauauuaaauagau
aucuucaggauuauggugcugaagcuuauguagccuucauuauuguguuu
gaauguguuuauguaaguggagccguaccuguugguuugucccauuauaa
ggacacuagcuucuuaaauggacaaauugcgucuagcaauaaugagauug
agcaauaacaggucugugaugcccuuagauguccugggcugcacgcgcgc
uacaaugaaaguaucaacguguauuuccuagaccgagagguccggguaaa
ccgcugaaccacuuucaugcuugggauugugaacugaaacuguucacgau
gaacuuggaauucccaguaagugugagucauuaacucgcauugauuacgu
cccugcccuuuguacacaccgcccgucgcuacuaccgauugaauuauuua
gugaggucuccggacgugaucacugugacgccuugcguguuacgguuguu
ucgcaaaaguugaccgaacuugauuauuuagaggaaguaaaagucguaac
aagguuuccguaggugaaccugcggaaggaucauua
...<<<<<.{.((((>>>>><<<<.<<<<<<...<.<<..<......<<<
.<<<..<<....<<....<<.........>>...>>.>>......<<...
.....<<<.<<<..<<....<<<<..............<<.....<<.<<
<.....>>>.>>......>>...........<<<<............>>>
>.<<..<<<<<.....(((...((..<<<<....>>>>........<...
.....>..>>>>>...>>...<...................>....>>>>
...>>>>>.>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>
>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..
........>>>.>>.<.<<....>>.>...>>>>>>.........<<<..
..<<<.....>>>..>>>..>...>>.>.....<.<<<<<...<<<....
..>>>....>>>>..>.>.....<<.................>>......
...<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>
..>>>>>>>>>>.........<<<[[.....<<<<...<<<.<<.....<
<<<...<<......................>>....>>>>......<<..
..................................................
..............................>>....<<<<<<.<<.....
..<<...<.......>..<<<.......>>>....>>.......>>.>>.
.>>>>..........................))...)))...........
.......>>....<<<<..<.<<...<<<<..<<..<<<<<<<<...<<<
......>>>......>>>>>>>.>.>>.......<<....>>...>>>>.
..>>>.>.>>>...>>>...>>>>....<<<<<<<...<...<<<<.<..
...>.>>>>...>>>>>>>>..........<<<.<<.<<<.<<<<<<...
.<<<........>>>...>>>>>>.>>>...<<..]]>>...>>......
>>>.>>>.<<<......<<<......>>>....>>>..)))).}<<....
<<<<<<<..<<..<<<<<.<<<<.<<<<<<......<<........>>..
........<<<<......................<<<........>>>..
...............<<.<<<...<.<<<<<.....<<<.<.........
.....................>.>>>....<<<<..<<..<.<.......
.<.........<..<...................................
.......................>..>.......>...<<<<........
>>>>..........>.>.>>............................>>
>>.....>>.>>>.....>.>>>>>........>>>>...>>.>>>>.>>
>.>...<<<<<<..............<<<.<<<<....>>>>.>>>....
..........>>>>>>.........<<.....<..........>....>>
.........>>>>>.....<<<<<<<<.......>>>>>>>>......>>
...>>>>>>>....>>....<..<<.<..<<<<.<<....<<<<.<<<.<
<<..<<<<..<....<<<<.<<....<<<.........>>>.....>>..
>>>>....>..>>>>..>>>.>>>.>>>>...>>.>>>>...>.>>...>
.....<<<<<<<<<....>>>>>>>>>.........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6xu8 Ribosome heterogeneity in Drosophila melanogaster gonads through paralog-switching.
Resolution3.0 Å
Binding residue
(original residue number in PDB)
K2 N4 P8 Q13 L15 R51 A53 G54 N56 Q59 G60 P62 Q65 G66 V67 R72 R74 L75 C83 Y84 R85 R88 T89 G90 R92 R94 K95 S96 V108 A110 V112 L114 R131 R132 L133 G134 P135 K136 R137 K140 R142 K149 R154 R159 R160 K168 K169 A170 K173 A174 P175 K176 I177 Q178 R179 L180 I181 V185 L186 Q187 R188 R191 R192 K196 K198 R199
Binding residue
(residue number reindexed from 1)
K2 N4 P8 Q13 L15 R51 A53 G54 N56 Q59 G60 P62 Q65 G66 V67 R72 R74 L75 C83 Y84 R85 R88 T89 G90 R92 R94 K95 S96 V108 A110 V112 L114 R131 R132 L133 G134 P135 K136 R137 K140 R142 K149 R154 R159 R160 K168 K169 A170 K173 A174 P175 K176 I177 Q178 R179 L180 I181 V185 L186 Q187 R188 R191 R192 K196 K198 R199
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0002181 cytoplasmic translation
GO:0006412 translation
GO:0042274 ribosomal small subunit biogenesis
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005840 ribosome
GO:0022626 cytosolic ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:0032040 small-subunit processome
GO:1990904 ribonucleoprotein complex

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Molecular Function

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Biological Process

View graph for
Cellular Component
External links
PDB RCSB:6xu8, PDBe:6xu8, PDBj:6xu8
PDBsum6xu8
PubMed34283226
UniProtP29327|RS6_DROME Small ribosomal subunit protein eS6 (Gene Name=RpS6)

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