Structure of PDB 7zud Chain A Binding Site BS01

Receptor Information

>7zud Chain A (length=210) Species: 11676 (Human immunodeficiency virus 1)

PIVQNLQGQMVHQCISPRTLNAWVKVVEEKAFSPEVIPMFSALSCGATPQ
DLNTMLNTVGGHQAAMQMLKETINEEAAEWDRLHPVHAGPIAPGQMREPR
GSDIAGTTSTLQEQIGWMTHNPPIPVGEIYKRWIILGLNKIVRMYSPTSI
LDIRQGPKEPFRDYVDRFYKTLRAEQTETLLVQNANPDCKTILKALGPGA
TLEEMMTACQ

Ligand information

>7zud Chain M (length=13) Species: 9606 (Homo sapiens)

PVLFPGQPFGQPP

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7zud CP-MAS and Solution NMR Studies of Allosteric Communication in CA-assemblies of HIV-1.
• Resolution: 2.93 Å
• Binding residue (original residue number in PDB): N53 L56 N57 M66 K70 N74 S102 G106 T107
• Binding residue (residue number reindexed from 1): N53 L56 N57 M66 K70 N74 S102 G106 T107

Enzymatic activity

• Enzyme Commision number: 2.7.7.-
  2.7.7.49: RNA-directed DNA polymerase.
  2.7.7.7: DNA-directed DNA polymerase.
  3.1.-.-
  3.1.13.2: exoribonuclease H.
  3.1.26.13: retroviral ribonuclease H.
  3.4.23.16: HIV-1 retropepsin.

Gene Ontology

Biological Process

• GO:0016032 viral process

External links

• PDB: RCSB:7zud, PDBe:7zud, PDBj:7zud
• PDBsum: 7zud
• PubMed: 35738429
• UniProt: P12497|POL_HV1N5 Gag-Pol polyprotein (Gene Name=gag-pol)