Structure of PDB 6x8k Chain A Binding Site BS01

Receptor Information
>6x8k Chain A (length=140) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NSYKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYE
VRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNGPV
DLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIET
Ligand information
Receptor-Ligand Complex Structure
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PDB6x8k Caspase-3 in complex with elongated ketomethylene inhibitor
Resolution2.17 Å
Binding residue
(original residue number in PDB)		M61 R64 H121 C163 T166
Binding residue
(residue number reindexed from 1)		M27 R30 H87 C129 T132
Enzymatic activity
Catalytic site (original residue number in PDB) T62 S63 H121 G122 C163
Catalytic site (residue number reindexed from 1) T28 S29 H87 G88 C129
Enzyme Commision number 3.4.22.56: caspase-3.
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:6x8k, PDBe:6x8k, PDBj:6x8k
PDBsum6x8k
PubMed
UniProtP42574|CASP3_HUMAN Caspase-3 (Gene Name=CASP3)

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