Structure of PDB 6d8a Chain A Binding Site BS01

Receptor Information
>6d8a Chain A (length=758) Species: 349102 (Cereibacter sphaeroides ATCC 17025) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RQLVSNGFEVNLPDQVEVIVRDLPDPSKVKEERTRLMGYWFVHWFDGKLF
HLRIKAGGPNVDGEHRAIRTAEHPWLLRARLDDALEEALPKYAAVKKRPF
TFLAQKDELIDAAATAAGLSHRLLNSFKVIPRFALSPKIYEPVDGTTRVG
VFVTIGMRYDIEASLRDLLEAGIDLRGMYVVRRKRQPGERGLLGRVRAIS
DDMVQLFEETDLASVNVNDAKLEGSKENFTRCLSALLGHNYKKLLNALDD
QEAGYRTGPRFDDAVRRMGEFLAKKPIRLADNINAQVGDRIVFSNEGQAR
NVRLAPKVEYVFDRTGAKSAEYAWRGLSQFGPFDRPSFANRSPRILVVYP
SSTQGKVENFLSAFRDGMGSNYSGFSKGFVDLMGLTKVEFVMCPVEVSSA
DRNGAHTKYNSAIEDKLAGAGEVHAGIVVLFEDHARLPDDRNPYIHTKSL
LLTLGVPTQQVRMPTVLLEPKSLQYTLQNFSIATYAKLNGTPWTVNHDKA
INDELVVGMGLAELSGSRTEKRQRFVGITTVFAGDGSYLLGNVSKECEYE
GYSDAIRESMTGILRELKKRNNWRPGDTVRVVFHAHRPLKRVDVASIVFE
CTREIGSDQNIQMAFVTVSHDHPFVLIDRSERGLEAYKGSTARKGVFAPP
RGAISRVGRLTRLLAVNSPQLIKRANTPLPTPLLVSLHPDSTFKDVDYLA
EQALKFTSLSWRSTLPAATPVTIFYSERIAELLGRLKSIPNWSSANLNIK
LKWSRWFL
Ligand information
Receptor-Ligand Complex Structure
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PDB6d8a Accommodation of Helical Imperfections in Rhodobacter sphaeroides Argonaute Ternary Complexes with Guide RNA and Target DNA.
Resolution2.251 Å
Binding residue
(original residue number in PDB)
P43 W63 D65 R151 G175 M176 R177 Y178 R204 R209 G210 L211 E242 G243 R275 A454 Y463 K467 Q478 Q479 R481 T484 T495 N498 F499 K506 R537 R541 R543 R606 K609 R610 K692 R731 S732 A737 F743 R754 L777
Binding residue
(residue number reindexed from 1)
P24 W44 D46 R132 G156 M157 R158 Y159 R185 R190 G191 L192 E223 G224 R256 A435 Y444 K448 Q459 Q460 R462 T465 T476 N479 F480 K487 R518 R522 R524 R587 K590 R591 K673 R712 S713 A718 F724 R735 L758
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0004520 DNA endonuclease activity
GO:0046872 metal ion binding
Biological Process
GO:0044355 clearance of foreign intracellular DNA

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Molecular Function

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Biological Process
External links
PDB RCSB:6d8a, PDBe:6d8a, PDBj:6d8a
PDBsum6d8a
PubMed29996105
UniProtA4WYU7|AGO_CERS5 Protein argonaute (Gene Name=ago)

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