Structure of PDB 5y31 Chain A Binding Site BS01

Receptor Information

>5y31 Chain A (length=482) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

NVEEETKYIELMIVNDHLMFKKHRLSVVHTNTYAKSVVNMADLIYKDQLK
TRIVLVAMETWATDNKFAISENPLITLREFMKYRRDFIKEKSDAVHLFSG
SQFESSRSGAAYIGGICSLLKGGGVNEFGKTDLMAVTLAQSLAHNIGIIS
DKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNIEEYHDFLNSGGGA
CLFNKPSKLLDPPECGNGFIETGEECDCGTPAECVLEGAECCKKCTLTQD
SQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDG
YSCDGVQGICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGN
CGKDKDTWIQCNKRDVLCGYLLCTNIGNIPRLGELDGEITSTLGRTLNCS
GGHVKLEEDVDLGYVEDGTPCGPQMMCLEHRCLPVASFNFSTCLSSKEGT
ICSGNGVCSNELKCVCNRHWIGSDCNTYFPHN

Ligand information

Ligand ID

InChI

InChI=1S/Ca/q+2

InChIKey

BHPQYMZQTOCNFJ-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Ca++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Ca+2]

Formula

Name

CALCIUM ION

PDB chain

5y31 Chain A Residue 801 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	5y31 Structural basis of epilepsy-related ligand-receptor complex LGI1-ADAM22.
Resolution	7.125 Å
Binding residue (original residue number in PDB)	E242 D325 C433 N436
Binding residue (residue number reindexed from 1)	E10 D93 C201 N204
Annotation score	4

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0004222	metalloendopeptidase activity
GO:0008237	metallopeptidase activity

	Biological Process
GO:0006508	proteolysis

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Molecular Function

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Biological Process

External links

PDB	RCSB:5y31, PDBe:5y31, PDBj:5y31
PDBsum	5y31
PubMed	29670100
UniProt	Q9P0K1\|ADA22_HUMAN Disintegrin and metalloproteinase domain-containing protein 22 (Gene Name=ADAM22)

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