Structure of PDB 2wzq Chain A Binding Site BS01

Receptor Information
>2wzq Chain A (length=581) Species: 12637 (Dengue virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EGVYRIMQGKTQVGVGIHMEGVFHTMWHVTRGSVICHGRLEPSWADVRND
MISYGGGWRLGDKWDDVQVLAIEPGKNPKHVQTKPGLFKTEIGAVTLDFK
PGTSGSPIINKKGKVIGLYGNGYVSAITQAERIGEGPDYEVDEDIFRKKR
LTIMDLHPGAGKTKRILPSIVREALKRRLRTLILAPTRVVAAEMEEALRG
LPIRYQTPAVKSDHTGREIVDLMCHATFTTRLLSSTRVPNYNLIVMDEAH
FTDPCSVAARGYISTRVEMGEAAAIFMTATPPGSTDPFPQSNSPIEDIER
EIPERSWNTGFDWITDYQGKTVWFVPSIKAGNDIANCLRKSGKRVIQLSR
KTFDTEYPKTKLTDWDFVVTTDISEMGANFRAGRVIDPRRCLKPVILTDG
PERVILAGPIPVTPASAAQRRGRIGRNPAQEDDQYVFSGDPLKNDEDHAH
WTEAKMLLDNIYTPEGIIPTLFGPEREKTQAIDGEFRLRGEQRKTFVELM
RRGDLPVWLSYKVASAGISYKDREWCFTGERNNQILEENMEVEIWTREGE
KKKLRPKWLDARVYADPMALKDFKEFASGRK
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2wzq Flexibility between the Protease and Helicase Domains of the Dengue Virus Ns3 Protein Conferred by the Linker Region and its Functional Implications.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		E20 G21 V22 Y23 R24 M26 Q27 V57 I58 Q96 H108 I140 K142 G144
Binding residue
(residue number reindexed from 1)		E1 G2 V3 Y4 R5 M7 Q8 V34 I35 Q68 H80 I109 K111 G113
Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003724 RNA helicase activity
GO:0004386 helicase activity
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:2wzq, PDBe:2wzq, PDBj:2wzq
PDBsum2wzq
PubMed20375022
UniProtQ2YHF0|POLG_DEN4T Genome polyprotein

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