Structure of PDB 2iuk Chain A Binding Site BS01

Receptor Information
>2iuk Chain A (length=835) Species: 3847 (Glycine max) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GQKIKGTVVLMPKNVLDFNAITSIVIDTATSFLGRNISMQLISATQTDGS
GNGKVGKEVYLEKHLPTLPTLGARQDAFSIFFEWDASFGIPGAFYIKNFM
TDEFFLVSVKLEDIPNHGTIEFVCNSWVYNFRSYKKNRIFFVNDTYLPSA
TPAPLLKYRKEEFEVLRGDGTGKRKDFDRIYDYDVYNDLGNPDGGDPRPI
LGGCSIYPYPLRVRTGRERTRTDPNSEKPGEVYVPRDENFGHLKSSDFLT
YGIKSLSHDVIPLFKSAIFQLRVTSSEFESFEDVRSLYEGGIKLPTDILS
QISPLPALKEIFRTDGENVLQFPPPHVAKVSKSGVMTDEEFAREVIAGVN
PNVIRRLQEFPPKSTLDPTLYGDQTSTITKEQLEINMGGVTVEEALSTQR
LFILDYQDAFIPYLTRINSLPTAKAYATRTILFLKDDGTLKPLAIELSKP
HPDGDNLGPESIVVLPATEGVDSTIWLLAKAHVIVNDSGYHQLVSHWLNT
HAVMEPFAIATNRHLSVLHPIYKLLYPHYRDTININGLARQSLINADGII
EKSFLPGKYSIEMSSSVYKNWVFTHQALPADLVKRGLAIEDPSAPHGLRL
VIEDYPYAVDGLEIWDAIKTWVHEYVSLYYPTDAAVQQDTELQAWWKEAV
EKGHGDLKEKPWWPKKQTTEDLIQSCSIIVWTASALHAAVNFGQYPYGGL
ILNRPTLARRFIPAEGTPEYDEMVKNPQKAYLRTITPKFETLIDLSVIEI
LSRHASDEIYLGERETPNWTTDKKALEAFKRFGSKLTGIEGKINARNSDP
SLRNRTGPVQLPYTLLHRSSEEGLTFKGIPNSISI
Ligand information
Ligand IDFE
InChIInChI=1S/Fe/q+3
InChIKeyVTLYFUHAOXGGBS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		[Fe+3]
FormulaFe
NameFE (III) ION
ChEMBL
DrugBankDB13949
ZINC
PDB chain2iuk Chain A Residue 901 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2iuk Crystal Structures of Vegetative Soybean Lipoxygenase Vlx-B and Vlx-D, and Comparisons with Seed Isoforms Lox-1 and Lox-3.
Resolution2.4 Å
Binding residue
(original residue number in PDB)		H525 H530 H716 N720 I864
Binding residue
(residue number reindexed from 1)		H496 H501 H687 N691 I835
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) H525 H530 H716 N720 I864
Catalytic site (residue number reindexed from 1) H496 H501 H687 N691 I835
Enzyme Commision number 1.13.11.58: linoleate 9S-lipoxygenase.
Gene Ontology
Molecular Function
GO:0005506 iron ion binding
GO:0016491 oxidoreductase activity
GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GO:0046872 metal ion binding
GO:0051213 dioxygenase activity
GO:1990136 linoleate 9S-lipoxygenase activity
Biological Process
GO:0006633 fatty acid biosynthetic process
GO:0031408 oxylipin biosynthetic process
GO:0034440 lipid oxidation
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2iuk, PDBe:2iuk, PDBj:2iuk
PDBsum2iuk
PubMed17022084
UniProtP24095|LOXX_SOYBN Seed linoleate 9S-lipoxygenase (Gene Name=LOX1.4)

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