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Posted: **Sun May 23, 2021 6:36 am**

I would like to ask about the formula 1 in section 2.2.1.
How are the formulas for fi （a） andr fi j（a,b） derived? Or is this formula derived in another paper? Can provide some relevant papers?
Thanks！

Posted: **Sun May 23, 2021 8:25 pm**

The calculation of frequencies with pseudo count has been used in many papers for coevolution analysis. For example, Eq 21 in plmDCA (https://arxiv.org/pdf/1211.1281.pdf), and Eq 1 in DCA paper (https://www.pnas.org/content/108/49/e1293).

Posted: **Mon May 24, 2021 6:58 am**

I clearly figured out this problem. Thank you for your answers sincerely.

Zhanglab forum

I have some questions about the formula in the ResPRE paper

I have some questions about the formula in the ResPRE paper

Re: I have some questions about the formula in the ResPRE paper

Re: I have some questions about the formula in the ResPRE paper