structure prediction
Posted: Mon Jul 21, 2025 10:21 am
I am currently studying the succinate dehydrogenase (SDH) complex, which is a hetero-tetrameric protein complex composed of four different subunits: SDHA, SDHB, SDHC, and SDHD (corresponding to Chains A, B, C, and D).
I would like to predict the 3D structure of the full SDH complex using only the amino acid sequences of each subunit.
Do any of your structure prediction servers (e.g., I-TASSER, D-I-TASSER, COTH, SPRING) support multi-chain or hetero-oligomer modeling for such complexes?
If multi-chain modeling is not supported, could you kindly recommend any tools (within or outside your platform) that are suitable for accurate sequence-based prediction of multi-subunit complexes like SDH?
Thank you very much for your time and guidance.
I would like to predict the 3D structure of the full SDH complex using only the amino acid sequences of each subunit.
Do any of your structure prediction servers (e.g., I-TASSER, D-I-TASSER, COTH, SPRING) support multi-chain or hetero-oligomer modeling for such complexes?
If multi-chain modeling is not supported, could you kindly recommend any tools (within or outside your platform) that are suitable for accurate sequence-based prediction of multi-subunit complexes like SDH?
Thank you very much for your time and guidance.