ProteinConformers: a large-scale and energetically profiled atomistic description of protein conformational landscapes

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ProteinConformers is an open, large-scale resource that maps protein conformational landscapes at atomistic resolution. The platform aggregates more than forty million CPU hours of simulation into an interactive environment where you can explore structure, energetics and function side by side. All the protein conformations, similarity annotations and energetic metrics are available for download. The current release of the ProteinConformers database (June 26, 2025) comprises 2,750,261 conformations across 734 diverse proteins, accompanied by 5,501,990 similarity annotations and 13,751,305 energetic profiles.

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