MetaGO result for job id PF12501

User Input

>k87_3771459_44_1/5-493 (489 residues)
WIVVIVVVLAVVGFVMGRMRALHSAGEDRRSLHSLPNYYGFNVAMFTAVPALLLLLVWMV
AQPLIVNARVSAEIPDALLDGSNMSLEMSDVRRVADGLDTAIAQGALSARQAANIDLQTT
DLREVLGSVGVALGSSVDPATLNAAQTYRGMTSVGDLAMTILVLLTAIAGFAFAYLRTNK
DFRARNTVEKGVRVLLIAAASIAILTTIGIVLSLVFNTIEFFRLYPISDFFLGTTWSPSF
GGGSELGILPLLWGTLYISLVALLVAVPIGLFAAVYLSEYATKSVRGIVKPLLEVLAGIP
TIVYGLFALLTVGPFLLSIFGANGPTAAMADGGWMHAGTAVMTAGLVMGIMLIPFVSSLS
DDIINAVPQSLRDGSYGLGATKSETIKQVILPAALPGIVGAVLLATSRAIGETMIVVLGA
GAAARLSMNPFDAMTTVTAKIVSQLTGDADFASPEALVAFALGMTLFVLTLGLNIFALYI
VRKYREQYE

Download query sequence and structure

Proteins with similar structure

Top 10 structural analogs in PDB (as identified by TM-align)

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov.	Download Alignment
1	5nz7A	0.44	7.73	0.051	0.759	Download
2	5h3zA	0.44	7.44	0.044	0.732	Download
3	2cqtA	0.44	7.45	0.068	0.732	Download
4	5a22A	0.44	7.33	0.035	0.720	Download
5	3qdeA	0.43	7.61	0.063	0.730	Download
6	1ulvA	0.42	7.35	0.053	0.695	Download
7	6ggyA	0.42	7.77	0.068	0.714	Download
8	1lf9A	0.41	7.51	0.072	0.693	Download
9	2cse1	0.41	7.43	0.055	0.681	Download
10	4zleA	0.41	7.54	0.047	0.683	Download

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov. represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted Gene Ontology (GO) Terms

Molecular Function (MF)

GO term	Cscore^GO	Name
GO:0022891	0.20	substrate-specific transmembrane transporter activity
GO:0042626	0.15	ATPase activity, coupled to transmembrane movement of substances
GO:0043225	0.13	anion transmembrane-transporting ATPase activity
GO:0015103	0.12	inorganic anion transmembrane transporter activity
GO:0015415	0.11	phosphate ion transmembrane-transporting ATPase activity

Download full result of the above consensus prediction.

Click the graph to show a high resolution version.

(a)

Cscore^GO is the confidence score of predicted GO terms. Cscore^GO values range in between [0-1]; where a higher value indicates a better confidence in predicting the function using the template.

(b)

The graph shows the predicted terms within the Gene Ontology hierachy for Molecular Function. Confidently predicted terms are color coded by Cscore^GO:

[0.13,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Biological Process (BP)

GO term	Cscore^GO	Name
GO:0006810	0.09	transport
GO:0071704	0.02	organic substance metabolic process
GO:0044238	0.02	primary metabolic process
GO:0015698	0.02	inorganic anion transport
GO:1902476	0.01	chloride transmembrane transport
GO:0071805	0.01	potassium ion transmembrane transport
GO:0048473	0.01	D-methionine transport
GO:0044117	0.01	growth of symbiont in host
GO:0042956	0.01	maltodextrin transport
GO:0031288	0.01	sorocarp morphogenesis

Download full result of the above consensus prediction.

Click the graph to show a high resolution version.

(a)

Cscore^GO is the confidence score of predicted GO terms. Cscore^GO values range in between [0-1]; where a higher value indicates a better confidence in predicting the function using the template.

(b)

The graph shows the predicted terms within the Gene Ontology hierachy for Biological Process. Confidently predicted terms are color coded by Cscore^GO:

[0.08,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Cellular Component (CC)

GO term	Cscore^GO	Name
GO:0005887	0.01	integral component of plasma membrane

Download full result of the above consensus prediction.

Click the graph to show a high resolution version.

(a)

Cscore^GO is the confidence score of predicted GO terms. Cscore^GO values range in between [0-1]; where a higher value indicates a better confidence in predicting the function using the template.

(b)

The graph shows the predicted terms within the Gene Ontology hierachy for Cellular Component. Confidently predicted terms are color coded by Cscore^GO:

[0.14,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Reference:

Chengxin Zhang, Peter L Freddolino, and Yang Zhang. (2018) MetaGO: A Structure and Protein-Protein Interaction Network Based Pipeline for Automated Protein Function Annotations. Journal of Molecular Biology.

[back to server]