MetaGO result for job id PF10056

User Input

>UniRef100_A0A0D2Y4F3/12-36 (25 residues)
ILAHQVHRIGHHVRETIVEEARAGL

Download query sequence and structure

Proteins with similar structure

Top 10 structural analogs in PDB (as identified by TM-align)

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov.	Download Alignment
1	6ewyA	0.90	0.73	0.120	1.000	Download
2	3jd8A1	0.90	0.79	0.080	1.000	Download
3	6gcvB	0.90	0.78	0.080	1.000	Download
4	5owvA	0.90	0.63	0.000	1.000	Download
5	4r61A	0.90	0.82	0.120	1.000	Download
6	1vx74	0.90	0.85	0.000	1.000	Download
7	2y44A	0.89	0.79	0.200	1.000	Download
8	4tqlA	0.89	0.81	0.040	1.000	Download
9	5cn0A	0.87	0.81	0.040	1.000	Download
10	4pkyB	0.87	0.82	0.040	1.000	Download

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov. represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted Gene Ontology (GO) Terms

Molecular Function (MF)

GO term	Cscore^GO	Name
GO:0050839	0.04	cell adhesion molecule binding
GO:0032403	0.04	protein complex binding
GO:0019904	0.04	protein domain specific binding
GO:0008092	0.04	cytoskeletal protein binding
GO:0005198	0.04	structural molecule activity
GO:0042609	0.02	CD4 receptor binding

Download full result of the above consensus prediction.

Click the graph to show a high resolution version.

(a)

Cscore^GO is the confidence score of predicted GO terms. Cscore^GO values range in between [0-1]; where a higher value indicates a better confidence in predicting the function using the template.

(b)

The graph shows the predicted terms within the Gene Ontology hierachy for Molecular Function. Confidently predicted terms are color coded by Cscore^GO:

[0.13,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Biological Process (BP)

GO term	Cscore^GO	Name
GO:0075512	0.04	clathrin-mediated endocytosis of virus by host cell
GO:0039654	0.04	fusion of virus membrane with host endosome membrane
GO:0034329	0.04	cell junction assembly
GO:0034109	0.04	homotypic cell-cell adhesion
GO:0032507	0.04	maintenance of protein location in cell
GO:0030865	0.04	cortical cytoskeleton organization
GO:0030683	0.04	evasion or tolerance by virus of host immune response
GO:0030168	0.04	platelet activation
GO:0030036	0.04	actin cytoskeleton organization
GO:0019082	0.04	viral protein processing

Download full result of the above consensus prediction.

Click the graph to show a high resolution version.

(a)

Cscore^GO is the confidence score of predicted GO terms. Cscore^GO values range in between [0-1]; where a higher value indicates a better confidence in predicting the function using the template.

(b)

The graph shows the predicted terms within the Gene Ontology hierachy for Biological Process. Confidently predicted terms are color coded by Cscore^GO:

[0.08,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Cellular Component (CC)

GO term	Cscore^GO	Name
GO:0005667	0.02	transcription factor complex
GO:0000790	0.02	nuclear chromatin
GO:0055036	0.01	virion membrane
GO:0044175	0.01	host cell endosome membrane
GO:0044174	0.01	host cell endosome
GO:0020002	0.01	host cell plasma membrane
GO:0019031	0.01	viral envelope
GO:0019012	0.01	virion

Download full result of the above consensus prediction.

Click the graph to show a high resolution version.

(a)

Cscore^GO is the confidence score of predicted GO terms. Cscore^GO values range in between [0-1]; where a higher value indicates a better confidence in predicting the function using the template.

(b)

The graph shows the predicted terms within the Gene Ontology hierachy for Cellular Component. Confidently predicted terms are color coded by Cscore^GO:

[0.14,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Reference:

Chengxin Zhang, Peter L Freddolino, and Yang Zhang. (2018) MetaGO: A Structure and Protein-Protein Interaction Network Based Pipeline for Automated Protein Function Annotations. Journal of Molecular Biology.

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