MetaGO result for job id MTG2

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User Input

>Q15125 (230 residues)
MTTNAGPLHPYWPQHLRLDNFVPNDRPTWHILAGLFSVTGVLVVTTWLLSGRAAVVPLGT
WRRLSLCWFAVCGFIHLVIEGWFVLYYEDLLGDQAFLSQLWKEYAKGDSRYILGDNFTVC
METITACLWGPLSLWVVIAFLRQHPLRFILQLVVSVGQIYGDVLYFLTEHRDGFQHGELG
HPLYFWFYFVFMNALWLVLPGVLVLDAVKHLTHAQSTLDAKATKAKSKKN

Download query sequence and structure

Proteins with similar structure

Top 10 structural analogs in PDB (as identified by TM-align)

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov.	Download Alignment
1	3wxvA	0.89	2.16	0.066	0.978	Download
2	5b2nA	0.70	3.69	0.068	0.930	Download
3	4xtlA	0.70	3.75	0.047	0.930	Download
4	4zwjA	0.69	4.09	0.062	0.965	Download
5	3ddlA	0.69	4.00	0.065	0.930	Download
6	5azdA	0.68	4.08	0.060	0.935	Download
7	4hyjA	0.67	3.90	0.063	0.896	Download
8	3a7kA	0.65	4.36	0.051	0.926	Download
9	1e0pA	0.65	4.03	0.077	0.887	Download
10	1uazA	0.65	3.98	0.059	0.874	Download

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov. represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted Gene Ontology (GO) Terms

Molecular Function (MF)

GO term	Cscore^GO	Name
GO:0003824	0.81	catalytic activity
GO:0016853	0.43	isomerase activity
GO:0016860	0.37	intramolecular oxidoreductase activity
GO:0016863	0.36	intramolecular oxidoreductase activity, transposing C=C bonds
GO:0004769	0.21	steroid delta-isomerase activity
GO:0038023	0.13	signaling receptor activity
GO:0043167	0.12	ion binding
GO:0004888	0.12	transmembrane signaling receptor activity
GO:0046872	0.11	metal ion binding
GO:0046983	0.08	protein dimerization activity

Download full result of the above consensus prediction.

Click the graph to show a high resolution version.

(a)

Cscore^GO is the confidence score of predicted GO terms. Cscore^GO values range in between [0-1]; where a higher value indicates a better confidence in predicting the function using the template.

(b)

The graph shows the predicted terms within the Gene Ontology hierachy for Molecular Function. Confidently predicted terms are color coded by Cscore^GO:

[0.13,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Biological Process (BP)

GO term	Cscore^GO	Name
GO:0044699	0.99	single-organism process
GO:0008152	0.97	metabolic process
GO:0071704	0.96	organic substance metabolic process
GO:0044238	0.93	primary metabolic process
GO:0044710	0.92	single-organism metabolic process
GO:0006629	0.84	lipid metabolic process
GO:0009987	0.74	cellular process
GO:0044281	0.58	small molecule metabolic process
GO:0009058	0.50	biosynthetic process
GO:0065007	0.47	biological regulation
GO:0044763	0.47	single-organism cellular process
GO:1901576	0.43	organic substance biosynthetic process
GO:0044711	0.42	single-organism biosynthetic process
GO:0032502	0.42	developmental process
GO:0050789	0.40	regulation of biological process
GO:1901360	0.37	organic cyclic compound metabolic process
GO:0050794	0.32	regulation of cellular process
GO:0044237	0.31	cellular metabolic process
GO:0008610	0.31	lipid biosynthetic process
GO:1901615	0.28	organic hydroxy compound metabolic process
GO:0008202	0.28	steroid metabolic process
GO:1901362	0.27	organic cyclic compound biosynthetic process
GO:0016125	0.26	sterol metabolic process
GO:0006694	0.26	steroid biosynthetic process
GO:1901617	0.25	organic hydroxy compound biosynthetic process
GO:0016126	0.23	sterol biosynthetic process
GO:0044767	0.18	single-organism developmental process
GO:0050896	0.10	response to stimulus
GO:0048519	0.10	negative regulation of biological process
GO:0065008	0.09	regulation of biological quality
GO:0044283	0.09	small molecule biosynthetic process

Download full result of the above consensus prediction.

Click the graph to show a high resolution version.

(a)

Cscore^GO is the confidence score of predicted GO terms. Cscore^GO values range in between [0-1]; where a higher value indicates a better confidence in predicting the function using the template.

(b)

The graph shows the predicted terms within the Gene Ontology hierachy for Biological Process. Confidently predicted terms are color coded by Cscore^GO:

[0.08,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Cellular Component (CC)

GO term	Cscore^GO	Name
GO:0044464	0.99	cell part
GO:0044424	0.96	intracellular part
GO:0044444	0.93	cytoplasmic part
GO:0043226	0.86	organelle
GO:0043229	0.83	intracellular organelle
GO:0043227	0.82	membrane-bounded organelle
GO:0016020	0.78	membrane
GO:0043231	0.77	intracellular membrane-bounded organelle
GO:0044425	0.36	membrane part
GO:0005783	0.30	endoplasmic reticulum
GO:0044422	0.23	organelle part
GO:0031224	0.22	intrinsic component of membrane
GO:0044446	0.21	intracellular organelle part
GO:0016021	0.21	integral component of membrane

Download full result of the above consensus prediction.

Click the graph to show a high resolution version.

(a)

Cscore^GO is the confidence score of predicted GO terms. Cscore^GO values range in between [0-1]; where a higher value indicates a better confidence in predicting the function using the template.

(b)

The graph shows the predicted terms within the Gene Ontology hierachy for Cellular Component. Confidently predicted terms are color coded by Cscore^GO:

[0.14,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

[Download result.tar.bz2 for all prediction results]

Reference:

Chengxin Zhang, Peter L. Freddolino, and Yang Zhang. MetaGO: Predicting Gene Ontology of non-homologous proteins through low-resolution protein structure prediction and protein-protein network mapping. Journal of Molecular Biology, in press (2018).

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