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COFACTOR result for job id 76593

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>76593 (119 residues)
MSYIQKRGQNTAWRTALMRNLTTELIINESLEVTQTRAKELRRHFDHMITLAKRGDLHSR
RQAASWLRDIDADKKETALQKLFNKLAKKYENRNGGYTSILKLDNRKGDNAPMVIIKLI

Download query sequence and structure

Proteins with similar structure

Top 10 structural analogs in PDB (as identified by TM-align)

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov.	Download Alignment
1	5o60O	0.91	1.15	0.389	0.950	Download
2	6i0yN	0.91	0.89	0.407	0.941	Download
3	1vw4L	0.90	1.73	0.316	0.983	Download
4	5t7vLQ	0.90	1.50	0.487	0.958	Download
5	3bboP	0.89	1.10	0.398	0.941	Download
6	1nkwL	0.88	1.05	0.393	0.933	Download
7	4v19R	0.87	1.31	0.327	0.941	Download
8	5myjBQ	0.85	1.69	0.547	0.950	Download
9	3j3vN	0.85	2.10	0.547	0.983	Download
10	1vspL	0.78	1.97	0.420	0.933	Download

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov. represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted Gene Ontology (GO) Terms

Molecular Function (MF)

GO term	Cscore^GO	Name
GO:0003735	1.00	structural constituent of ribosome

Download full result of the above consensus prediction.

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(a)

Cscore^GO is the confidence score of predicted GO terms. Cscore^GO values range in between [0-1]; where a higher value indicates a better confidence in predicting the function using the template.

(b)

The graph shows the predicted terms within the Gene Ontology hierachy for Molecular Function. Confidently predicted terms are color coded by Cscore^GO:

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[0.7,0.8)

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[0.9,1.0]

Biological Process (BP)

GO term	Cscore^GO	Name
GO:0009987	1.00	cellular process
GO:0071840	0.95	cellular component organization or biogenesis
GO:0016043	0.94	cellular component organization
GO:0000002	0.93	mitochondrial genome maintenance
GO:0071704	0.89	organic substance metabolic process
GO:0044237	0.89	cellular metabolic process
GO:0044238	0.87	primary metabolic process
GO:0006807	0.87	nitrogen compound metabolic process
GO:0043170	0.86	macromolecule metabolic process
GO:0034641	0.85	cellular nitrogen compound metabolic process
GO:0044260	0.82	cellular macromolecule metabolic process
GO:1901576	0.81	organic substance biosynthetic process
GO:1901564	0.81	organonitrogen compound metabolic process
GO:0044249	0.81	cellular biosynthetic process
GO:0034645	0.79	cellular macromolecule biosynthetic process
GO:0044271	0.78	cellular nitrogen compound biosynthetic process
GO:1901566	0.77	organonitrogen compound biosynthetic process
GO:0044267	0.77	cellular protein metabolic process
GO:0043603	0.76	cellular amide metabolic process
GO:0006412	0.75	translation

Download full result of the above consensus prediction.

Click the graph to show a high resolution version.

(a)

Cscore^GO is the confidence score of predicted GO terms. Cscore^GO values range in between [0-1]; where a higher value indicates a better confidence in predicting the function using the template.

(b)

The graph shows the predicted terms within the Gene Ontology hierachy for Biological Process. Confidently predicted terms are color coded by Cscore^GO:

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Cellular Component (CC)

GO term	Cscore^GO	Name
GO:0043229	1.00	intracellular organelle
GO:0015934	1.00	large ribosomal subunit
GO:0043232	0.65	intracellular non-membrane-bounded organelle
GO:0005840	0.64	ribosome
GO:0005622	0.63	intracellular
GO:0044445	0.60	cytosolic part
GO:0022625	0.53	cytosolic large ribosomal subunit

Download full result of the above consensus prediction.

Click the graph to show a high resolution version.

(a)

Cscore^GO is the confidence score of predicted GO terms. Cscore^GO values range in between [0-1]; where a higher value indicates a better confidence in predicting the function using the template.

(b)

The graph shows the predicted terms within the Gene Ontology hierachy for Cellular Component. Confidently predicted terms are color coded by Cscore^GO:

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted Enzyme Commission (EC) Numbers

Top 5 enzyme homologs in PDB

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov.	EC Number	Predicted Active Site Residues
1	0.060	1h0hA	0.417	4.94	0.124	0.815	1.2.1.2	NA
2	0.060	3ii9C	0.522	2.99	0.061	0.698	1.3.99.7	NA
3	0.060	1xxiA	0.477	4.07	0.067	0.773	2.7.7.7	NA
4	0.060	2ix6E	0.517	3.48	0.070	0.723	1.3.3.6	19
5	0.060	3djlA	0.469	4.00	0.059	0.756	1.3.99.-	NA

	Click on the radio buttons to visualize predicted active site residues.
(a)	Cscore^EC is the confidence score for the Enzyme Commission (EC) number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov. represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted Ligand Binding Sites

Template proteins with similar binding site:

Rank	Cscore^LB	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov.	BS-score	Lig. Name	Download Complex	Predicted binding site residues
1	0.01	2ix5B	0.518	3.32	0.079	0.714	0.19	FAD	Download	7,9,17,109
2	0.01	2ix6D	0.516	3.59	0.070	0.731	0.19	FAD	Download	37,106,109
3	0.01	1vsa8	0.135	3.23	0.073	0.193	0.39	III	Download	93,97,98,100,101,108
4	0.01	2ix5A	0.512	3.61	0.078	0.731	0.23	FAD	Download	33,34,107,109
5	0.01	2r0nA	0.378	4.47	0.057	0.681	0.10	TGC	Download	41,42,45,46,49

	Click on the radio buttons to visualize predicted binding site and residues.
(a)	Cscore^LB is the confidence score of predicted binding site. Cscore^LB values range in between [0-1]; where a higher score indicates a more reliable ligand-binding site prediction.
(b)	BS-score is a measure of local similarity (sequence & structure) between template binding site and predicted binding site in the query structure. Based on large scale benchmarking analysis, we have observed that a BS-score >1 reflects a significant local match between the predicted and template binding site.
(c)	TM-score is a measure of global structural similarity between query and template protein.
(d)	RMSD^a the RMSD between residues that are structurally aligned by TM-align.
(e)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(f)	Cov. represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

[Download result.tar.bz2 for all prediction results]

Reference:

Chengxin Zhang, Peter L Freddolino, and Yang Zhang. COFACTOR: Improved protein function prediction by combining structure, sequence, and protein-protein interaction information. Nucleic Acids Research, 45: W291-299 (2017)
Ambrish Roy, Jianyi Yang, and Yang Zhang. COFACTOR: An accurate comparative algorithm for structure-based protein function annotation. Nucleic Acids Research, 40:W471-W477 (2012).

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