D-I-TASSER Q8N157-D1

D-I-TASSER results for Q8N157-D1

[Click result.zip to download all results on this page]

Input Sequence in FASTA format

>Q8N157 (444 residues)
MPTAESEAKVKTKVRFEELLKTHSDLMREKKKLKKKLVRSEENISPDTIRSNLHYMKETT
SDDPDTIRSNLPHIKETTSDDVSAANTNNLKKSTRVTKNKLRNTQLATENPNGDASVEED
KQGKPNKKVIKTVPQLTTQDLKPETPENKVDSTHQKTHTKPQPGVDHQKSEKANEGREET
DLEEDEELMQAYQCHVTEEMAKEIKRKIRKKLKEQLTYFPSDTLFHDDKLSSEKRKKKKE
VPVFSKAETSTLTISGDTVEGEQKKESSVRSVSSDSHQDDEISSMEQSTEDSMQDDTKPK
PKKTKKKTKAVADNNEDVDGDGVHEITSRDSPVYPKCLLDDDLVLGVYIHRTDRLKSDFM
ISHPMVKIHVVDEHTGQYVKKDDSGRPVSSYYEKENVDYILPIMTQPYDFKQLKSRLPEW
EEQIVFNENFPYLLRGSDESPKVI

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MPTAESEAKVKTKVRFEELLKTHSDLMREKKKLKKKLVRSEENISPDTIRSNLHYMKETTSDDPDTIRSNLPHIKETTSDDVSAANTNNLKKSTRVTKNKLRNTQLATENPNGDASVEEDKQGKPNKKVIKTVPQLTTQDLKPETPENKVDSTHQKTHTKPQPGVDHQKSEKANEGREETDLEEDEELMQAYQCHVTEEMAKEIKRKIRKKLKEQLTYFPSDTLFHDDKLSSEKRKKKKEVPVFSKAETSTLTISGDTVEGEQKKESSVRSVSSDSHQDDEISSMEQSTEDSMQDDTKPKPKKTKKKTKAVADNNEDVDGDGVHEITSRDSPVYPKCLLDDDLVLGVYIHRTDRLKSDFMISHPMVKIHVVDEHTGQYVKKDDSGRPVSSYYEKENVDYILPIMTQPYDFKQLKSRLPEWEEQIVFNENFPYLLRGSDESPKVI
Prediction	CCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCSSSSSSSSCCCCCCCCCCCCCCSSSSSSSSCCCCCSSSCCCCCCCCSSSCCCCCCCSSCSSCCCCSCHHHCCCCCCCCCSSSSSSCCHHHHHCCCCCCCCCC
Confidence	986421110111135666654313632332110221157744434310246631101355333222234434433467755554557886556543212333333456785446554443445641010244545554444567765456641221256666677543334444445643345421122322111101123332233311123442037753344322355322334457777544456654345665444434567766556555777433445555322211135455542223333345677656665555666555665554568886289999950354335544457458999985678814533678875201204687426600015750344416778753203565021356632589998659
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MPTAESEAKVKTKVRFEELLKTHSDLMREKKKLKKKLVRSEENISPDTIRSNLHYMKETTSDDPDTIRSNLPHIKETTSDDVSAANTNNLKKSTRVTKNKLRNTQLATENPNGDASVEEDKQGKPNKKVIKTVPQLTTQDLKPETPENKVDSTHQKTHTKPQPGVDHQKSEKANEGREETDLEEDEELMQAYQCHVTEEMAKEIKRKIRKKLKEQLTYFPSDTLFHDDKLSSEKRKKKKEVPVFSKAETSTLTISGDTVEGEQKKESSVRSVSSDSHQDDEISSMEQSTEDSMQDDTKPKPKKTKKKTKAVADNNEDVDGDGVHEITSRDSPVYPKCLLDDDLVLGVYIHRTDRLKSDFMISHPMVKIHVVDEHTGQYVKKDDSGRPVSSYYEKENVDYILPIMTQPYDFKQLKSRLPEWEEQIVFNENFPYLLRGSDESPKVI
Prediction	654344634452443034114425634654553554455465414254245536435554465555446545446546656344554555554454547426646536453655354555665455553564456465664555435564554554455655554556456635554555535564443544535345644642454355535543463456544564546766455556464455554444535556565564554555525655545543464554365546554564554454555435555563556436534575455565544453210101022024031532031000000001141241033654633122223564131010000331314535333230421010244042004537742403
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Contact, Hydrogen and Distance Map Used in D-I-TASSER simulation

Contact Map

Distance Map

Hydrogen bond networks

D-I-TASSER simulation is guided by the consensus contact map (left figure), distance map (middle figure) and Hydrogen bond network (right figure) derived based on confidence scores of AttentionPotential. In the contact, distance map and hydrogen bond networks, the axes mark the residue index along the sequence. For the contact map, each dot represents a residue pair with predicted contact, while for the distance map and hydrogen bond network, a color scale represents a distance of 1-20+ angstroms or a angle of 0-180 degree.

Top 10 threading templates used by D-I-TASSER

Rank

PDB
hit

ID1

ID2

Cov

Norm.
Zscore

Download
alignment

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420                 440

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

SS
Seq

CCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCSSSSSSSSCCCCCCCCCCCCCCSSSSSSSSCCCCCSSSCCCCCCCCSSSCCCCCCCSSCSSCCCCSCHHHCCCCCCCCCSSSSSSCCHHHHHCCCCCCCCCC
MPTAESEAKVKTKVRFEELLKTHSDLMREKKKLKKKLVRSEENISPDTIRSNLHYMKETTSDDPDTIRSNLPHIKETTSDDVSAANTNNLKKSTRVTKNKLRNTQLATENPNGDASVEEDKQGKPNKKVIKTVPQLTTQDLKPETPENKVDSTHQKTHTKPQPGVDHQKSEKANEGREETDLEEDEELMQAYQCHVTEEMAKEIKRKIRKKLKEQLTYFPSDTLFHDDKLSSEKRKKKKEVPVFSKAETSTLTISGDTVEGEQKKESSVRSVSSDSHQDDEISSMEQSTEDSMQDDTKPKPKKTKKKTKAVADNNEDVDGDGVHEITSRDSPVYPKCLLDDDLVLGVYIHRTDRLKSDFMISHPMVKIHVVDEHTGQYVKKDDSGRPVSSYYEKENVDYILPIMTQPYDFKQLKSRLPEWEEQIVFNENFPYLLRGSDESPKVI

6zywY

0.09

3.24

1.53

SPARKS-K

KNYDKFFVSKLIYVVAKRLTGHFNSAAGQLGDM--KMHKRNLATESQLTEIFRDTYEIEEISKWVQIRGVNAALPKP----RVLFGKNTSADCSKEPSVAPLKDLKYSETFHSFHATFETFDLRTCLRAARTYFLAKGVKEERNLITLNDDEGVPQGYELNIDENQQYKDQDFLANLYLSIIIGFNEVMQLITKDYKNMTEEFIQDYIFQKVSKVYAGFQIPSFGEEVKIDFKDTISFKLTPYFFMVRIEQKNIKSQILNNTVLQEGCYLLLTKEIPYFDLWNCQNDYSEKIEKMKKRILWEPLKQISDELPKNRIFVQTGRKSNYGFDIPIMQASYYMHEL---G------------LRIETQ---------RLGWFILFFKEMKEI-QITQKMNHTWLIFKVDSNITFNSISKDTIALEFTGDALEQSFFKIKNYFEENQIK

1vt4I3

0.04

0.03

1.88

1.21

MapAlign

ICDNDPKYERLVNAILDFLPKAEDEAIFEEAHKQVQGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGG-GGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGG---------------GGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGG

2pffB

0.16

0.13

4.40

1.38

HHsearch

-------------------MDAYSTRPLT------LSHGSLEHV---LLVPTASFFIA--SQLQEQFNKI--LPEPTEGFAAD-DEPTTPASLVEPSKVGQFDQVLLTEFENCYLEGNDIHALAALVKTKEL-IKNYIRIMAKRPFDKKSNSAL-------FRAVGEGNAQVAIFGGQGNTDDYFEELRDLYQTYHVLV-GD-----LIKFSAETLSELIRTTLDAEKVFTQGLNIEWLENPSNTPDKDYLFTPGESYLKGATGH--SQGLVTAVA-----I-AETD--------SWESFFVSVRKAITVL-F----FI--GVRCYEAYPNTSLPPSILEDSLEN------------NEGVPSPMLSISNLTQEQVQYVNKTNSHLPAGKQVEISLVNLVVRKAKAPSGLD--QSRIPFSERKLKFSNRFLPVASPFHSHLLVP

1vt4I3

0.04

1.95

0.62

CEthreader

LPKIEENLICSKYTDLLRIALMAEDEAIFEEAHKQVQRGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGG---------GGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGG

3gjxA

0.04

2.04

0.78

EigenThreader

KDTDSINLYKNMRETLVYLTHLDYVDTEIIMTKKLQNQVNGTEWSWKNLNTLCWAIGSISGAMHEEDEKRFLVTVIKDLLGLCEQK-RGKDNKAIIASNIMYIVGQYPRFLRAHWKFLKTVVNKLFEFMHETHDGVQDMACDTFIKIAQKCRRHFVQVQVGEVMPFIDEILNNINTIICDLQPQQVHTFYEAVGYMIGTVQEHLIEKYMLLPNQVWDSIIQQATKNVDILKDPETVKQLGSILKTNVRACKAVGHPFVIQLGRIYLDMLNVYKCLSENISAAIQANGVKRETLKLISGWVSRSNDPQMVAENFVPPLLDAVLIDYQRNVPAAREP--------------EVLSTMAIIVNKLGGHI-------TAEITLNMINKDFEEYPEHRTNFFLLLQAVNSHCFP---AFLAIPPAQFKLVLDSIIWAFKHTMRNVADTG

1kvpA

0.09

0.07

2.77

0.51

FFAS-3D

TINPDTKIPKHLFQGYLNIYNNY---------FKAPWMPDRTEANPNELNQDDARYGFRCCHLKNIWTAPLP----------------PETELSRQMTTSTGMAPVTTKFRDVPNLSGTPLIFRDNKGRTIKTGQLGIGPVDAGFLVAQNTAQAANGERAIPSNLWADLSNATS--------IDIMGLQAAYANLHTDQERDYFMQRYRDVISSFGGKTSYDADNRPLLVMR----SNLWASGYDVDGTDQTSLGQFSGRVQQTYKHSVPRFFVPEHG-TMFTLALVRFPPTATKEIQYLNAKGALTYTDIAGDPVLYGNLPPREISMKDVFRSG----DSSKKFKI--AEGQWYRYA------------PSYVSPAYHLLEGRHHDYDQCFQSVQLLQWN--SQVKFNVTVYRN-LPTTRDSIM-------------------

6em5I

0.06

2.41

1.47

SPARKS-K

------EKILQLKEDIADLVTKVMENTAALGRLCKMVESKNPNTCKFSMLALVPVFVSKLRNFEQALVYNQSLSKTPSNAAPIQVSLGILSTASHFNFRRICKPRISTDPTSIQIIQTFETLLNEDEEGSISIFNKILKTRNFNIEESVLNMLLSLDVLHDYDKKKDRVHLSKKQRKARKEMQQIEEEMRNAEQAVSAEERERNQSEILKIVFTIYLNINNAKTLIGSVLEGLTKFGNMANFDLLGDFLEVMKELISDTEFDAEVRKALLCINTQYMKLSKFVDGLYALLPYICLDADIELSYRSLRLADPLNNEIIKPSVNVSTKAELLLKALDHVFFRSKSGTKERATAFTKRLYMCISHTPEKTSIAILKFIDKLMNRYPEIAATLWDNALLEKHYCPVV-----------------------------------------

4iloA

0.11

0.04

1.47

0.60

CNFpred

--SNAMHDALQSILAIQELDIKMIRLMRVKKEHQNELAKIQALKT--DIRRKVEEKE----QEMEKLKDQI------------------------------------------KGGEKRIQEISDQINKLENQQAAVKKMDEFNALTQEMTAANKERRTLEHQLSDLMDKQAGSEDLLISLKESLSSTENSSSAIEEEIRENIRINEEGRSLLSQRTQ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

6djyB

0.03

0.02

1.01

0.67

DEthreader

SAFISHIVLMMMDRK-----W---IV-QFHALNIDYFSQA-NVFTVK-SENA-VK--------RICAIDKTVIDDYFSLEMTP---IIMRPKLYDLILFSIPTLIQILSMYAFRQYLKFIFSLFTDKTTSLTPDDR--------------------------------------------NIGGRTQ-DGHVYHLYNVMANMMQNTILKTSIDAICSVEGILLLILTLNKLRTGISQ--VKGLILH-KR--------------LTIPTDVKTIVLTQHIFLIGVKILAEDIK-ANNGF--------------------------------------ITADVQF-------------------------EIMFFDNA-----------------NSSIITQRIS-SE-DMGKIDETSGEPIQKMVSMA-----------------

3j65q

0.09

0.07

2.86

0.92

MapAlign

VPGAISEKQLEELLNQLNPVKTIDITDNLYSITLLYTPRAVFKVKPVTRSSSAIAGHGSTILCSAFAPHTSSRMVTGAGDNTARIWDCDTQTPMHTLKGHYNWVLCVSWSPDGEVIATGSMDNTI--------------------------------RLWDPKSGQCLGDALRGHSKWITSLSWEPIHLVKPGSKPRLASSSKDGTIKIWDTVSRVCQY-TMSGHTNSVSCVKWGGQGLLYSGSHDRTVRVWDINSQGRCINILKSHAHWVNHLSLSMMVTASDDYTMFLWNPLKSTKPIARMTGHQKLVNHVAFSPDGRYIVSASFD------------------NSIKLWDGRDGKFISTFRSVYQVAWSSDCRLLVSCSKDTTLKVWDVRTRKLSVDLPGHKDEVYTVDWSVDGKR-------------VCSGGKDKMVRL

(a)	ID1 is the number of template residues identical to query divided by number of aligned residues.
(b)	ID2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment and is highlighted in bold.
(e)	Download alignment lists the threading program used to identify the template, and provide the 3D structure of aligned regions of threading templates (threading[1-10].pdb.gz).
(f)	Template residues identical to query sequence are highlighted in color.

Top 1 final models from D-I-TASSER

Click to view	Rank^a	Download	Estimated TM-score^b
	1	model1.pdb.gz	0.5816

(a)

D-I-TASSER simulations generate a large ensemble of structural conformations, i.e. decoys. These decoys are clustered by SPICKER based on pairwise structure similarity to report up to five final models from the five largest clusters. Models are ranked in descending order of cluster size. If the simulations converge well, it is possible to have less than 5 models generated, which is usually an indication of good model quality.

(b)

The model confidence is quantitatified by estimated TM-score (eTM-score), calculated based on significance of threading template alignments, contact map satisfaction rate, mean absolute error between distance of model and distance of AttentionPotential, and convergence of D-I-TASSER simulations. eTM-score is typically in the range of [0, 1], with higher eTM-score signifies higher model confidence.

Proteins with similar structure

Top 10 structural analogs in PDB (as identified by TM-align)

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov.	Download Alignment
1	6djyB	0.36	7.03	0.017	0.592	model1_6djyB.pdb.gz
2	5b2oA	0.36	7.41	0.047	0.604	model1_5b2oA.pdb.gz
3	1vw1A	0.34	7.34	0.060	0.581	model1_1vw1A.pdb.gz
4	7lkpA	0.34	6.80	0.047	0.534	model1_7lkpA.pdb.gz
5	6zymA	0.34	7.74	0.044	0.606	model1_6zymA.pdb.gz
6	3cnfB	0.34	7.24	0.043	0.559	model1_3cnfB.pdb.gz
7	1m1cA	0.26	7.17	0.027	0.428	model1_1m1cA.pdb.gz
8	4p0dA	0.21	7.25	0.031	0.342	model1_4p0dA.pdb.gz
9	1zxnC	0.16	7.41	0.016	0.281	model1_1zxnC.pdb.gz
10	1yfiA	0.15	6.15	0.055	0.223	model1_1yfiA.pdb.gz

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov. represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted Gene Ontology (GO) Terms

Molecular Function (MF)

GO term	Cscore^GO	Name
GO:0042802	1.00	identical protein binding

Download full result of the above consensus prediction.

Click the graph to show a high resolution version.

(a)

Cscore^GO is the confidence score of predicted GO terms. Cscore^GO values range in between [0-1]; where a higher value indicates a better confidence in predicting the function using the template.

(b)

The graph shows the predicted terms within the Gene Ontology hierachy for Molecular Function. Confidently predicted terms are color coded by Cscore^GO:

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Biological Process (BP)

GO term	Cscore^GO	Name
GO:0044767	1.00	single-organism developmental process
GO:0030030	1.00	cell projection organization
GO:0009653	0.96	anatomical structure morphogenesis
GO:0060271	0.95	cilium morphogenesis
GO:0065007	0.79	biological regulation
GO:0050789	0.79	regulation of biological process
GO:0050794	0.78	regulation of cellular process
GO:0048856	0.77	anatomical structure development
GO:0044707	0.77	single-multicellular organism process
GO:1902589	0.76	single-organism organelle organization
GO:0022607	0.76	cellular component assembly
GO:0042384	0.75	cilium assembly
GO:0007389	0.75	pattern specification process
GO:0080090	0.73	regulation of primary metabolic process
GO:0060255	0.73	regulation of macromolecule metabolic process
GO:0048518	0.73	positive regulation of biological process
GO:0048513	0.73	animal organ development
GO:0031323	0.73	regulation of cellular metabolic process
GO:0071599	0.72	otic vesicle development
GO:0031325	0.72	positive regulation of cellular metabolic process
GO:0010604	0.72	positive regulation of macromolecule metabolic process
GO:0010468	0.72	regulation of gene expression
GO:0007165	0.72	signal transduction
GO:0006810	0.72	transport
GO:0070986	0.71	left/right axis specification
GO:0070121	0.71	Kupffer's vesicle development
GO:0051128	0.71	regulation of cellular component organization
GO:0048523	0.71	negative regulation of cellular process
GO:0045893	0.71	positive regulation of transcription, DNA-templated
GO:0039023	0.71	pronephric duct morphogenesis
GO:0008104	0.71	protein localization
GO:0007166	0.71	cell surface receptor signaling pathway
GO:0006357	0.71	regulation of transcription from RNA polymerase II promoter
GO:0050795	0.70	regulation of behavior
GO:0045944	0.70	positive regulation of transcription from RNA polymerase II promoter
GO:0043066	0.70	negative regulation of apoptotic process
GO:0035845	0.70	photoreceptor cell outer segment organization
GO:0034613	0.70	cellular protein localization
GO:0030862	0.70	positive regulation of polarized epithelial cell differentiation
GO:0016192	0.70	vesicle-mediated transport
GO:0007169	0.70	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0002092	0.70	positive regulation of receptor internalization
GO:0001738	0.70	morphogenesis of a polarized epithelium
GO:0065001	0.68	specification of axis polarity
GO:0039008	0.68	pronephric nephron tubule morphogenesis
GO:0035844	0.68	cloaca development
GO:0030902	0.68	hindbrain development
GO:0010842	0.68	retina layer formation
GO:0007417	0.68	central nervous system development
GO:0001947	0.68	heart looping

Download full result of the above consensus prediction.

Click the graph to show a high resolution version.

(a)

Cscore^GO is the confidence score of predicted GO terms. Cscore^GO values range in between [0-1]; where a higher value indicates a better confidence in predicting the function using the template.

(b)

The graph shows the predicted terms within the Gene Ontology hierachy for Biological Process. Confidently predicted terms are color coded by Cscore^GO:

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Cellular Component (CC)

GO term	Cscore^GO	Name
GO:0044464	1.00	cell part
GO:0043226	1.00	organelle
GO:0044430	0.99	cytoskeletal part
GO:0005929	0.99	cilium
GO:0072372	0.98	primary cilium
GO:0036064	0.98	ciliary basal body
GO:0044444	0.77	cytoplasmic part
GO:0043229	0.77	intracellular organelle
GO:0030054	0.73	cell junction
GO:0031513	0.72	nonmotile primary cilium
GO:0005912	0.72	adherens junction
GO:0005911	0.72	cell-cell junction
GO:0005814	0.72	centriole
GO:0005813	0.71	centrosome

Download full result of the above consensus prediction.

Click the graph to show a high resolution version.

(a)

Cscore^GO is the confidence score of predicted GO terms. Cscore^GO values range in between [0-1]; where a higher value indicates a better confidence in predicting the function using the template.

(b)

The graph shows the predicted terms within the Gene Ontology hierachy for Cellular Component. Confidently predicted terms are color coded by Cscore^GO:

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted Enzyme Commission (EC) Numbers

Top 5 enzyme homologs in PDB

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov.	EC Number	Predicted Active Site Residues
1	0.060	1qhaA	0.294	6.70	0.031	0.471	2.7.1.1	353
2	0.060	2rd0A	0.227	7.55	0.031	0.399	2.7.1.153	NA
3	0.060	2nztA	0.269	7.57	0.057	0.462	2.7.1.1	NA
4	0.060	2pffA	0.278	7.10	0.015	0.457	2.3.1.41 2.3.1.86	NA
5	0.060	1eulA	0.347	7.30	0.052	0.579	3.6.3.8	NA

	Click on the radio buttons to visualize predicted active site residues.
(a)	Cscore^EC is the confidence score for the Enzyme Commission (EC) number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov. represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted Ligand Binding Sites

Template proteins with similar binding site:

No Binding sites was predicted

Click to view	Rank	Cscore^LB	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov.	BS-score	Lig. Name	Download Complex	Predicted binding site residues

	Click on the radio buttons to visualize predicted binding site and residues.
(a)	Cscore^LB is the confidence score of predicted binding site. Cscore^LB values range in between [0-1]; where a higher score indicates a more reliable ligand-binding site prediction.
(b)	BS-score is a measure of local similarity (sequence & structure) between template binding site and predicted binding site in the query structure. Based on large scale benchmarking analysis, we have observed that a BS-score >1 reflects a significant local match between the predicted and template binding site.
(c)	TM-score is a measure of global structural similarity between query and template protein.
(d)	RMSD^a the RMSD between residues that are structurally aligned by TM-align.
(e)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(f)	Cov. represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

[Click result.zip to download all results on this page]

References:
1.	Wei Zheng, Chengxin Zhang, Yang Li, Robin Pearce, Eric W. Bell, Yang Zhang. Folding non-homology proteins by coupling deep-learning contact maps with I-TASSER assembly simulations. In preparation, 2020.