D-I-TASSER Q6UWW8-D1

D-I-TASSER results for Q6UWW8-D1

[Click result.zip to download all results on this page]

Input Sequence in FASTA format

>Q6UWW8 (469 residues)
MERAVRVESGVLVGVVCLLLACPATATGPEVAQPEVDTTLGRVRGRQVGVKGTDRLVNVF
LGIPFAQPPLGPDRFSAPHPAQPWEGVRDASTAPPMCLQDVESMNSSRFVLNGKQQIFSV
SEDCLVLNVYSPAEVPAGSGRPVMVWVHGGALITGAATSYDGSALAAYGDVVVVTVQYRL
GVLGFFSTGDEHAPGNQGFLDVVAALRWVQENIAPFGGDLNCVTVFGGSAGGSIISGLVL
SPVAAGLFHRAITQSGVITTPGIIDSHPWPLAQKIANTLACSSSSPAEMVQCLQQKEGEE
LVLSKKLKNTIYPLTVDGTVFPKSPKELLKEKPFHSVPFLMGVNNHEINVPTVSFSRYLR
DSGSPVFFYEFQHRPSSFAKIKPAWVKADHGAEGAFVFGGPFLMDESSRLAFPEATEEEK
QLSLTMMAQWTHFARTGDPNSKALPPWPQFNQAEQYLEINPVPRAGQKF

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MERAVRVESGVLVGVVCLLLACPATATGPEVAQPEVDTTLGRVRGRQVGVKGTDRLVNVFLGIPFAQPPLGPDRFSAPHPAQPWEGVRDASTAPPMCLQDVESMNSSRFVLNGKQQIFSVSEDCLVLNVYSPAEVPAGSGRPVMVWVHGGALITGAATSYDGSALAAYGDVVVVTVQYRLGVLGFFSTGDEHAPGNQGFLDVVAALRWVQENIAPFGGDLNCVTVFGGSAGGSIISGLVLSPVAAGLFHRAITQSGVITTPGIIDSHPWPLAQKIANTLACSSSSPAEMVQCLQQKEGEELVLSKKLKNTIYPLTVDGTVFPKSPKELLKEKPFHSVPFLMGVNNHEINVPTVSFSRYLRDSGSPVFFYEFQHRPSSFAKIKPAWVKADHGAEGAFVFGGPFLMDESSRLAFPEATEEEKQLSLTMMAQWTHFARTGDPNSKALPPWPQFNQAEQYLEINPVPRAGQKF
Prediction	CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCSSSSCCSSSSSSSSSSCCCCCSSSSSSCCCCCCCCCCCCCCCCCCCCCCCCCCSSCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCSSSSSSCCCCCCCCCCSSSSSSCCCCCCCCCCCCCCHHHHHHCCCSSSSSSCCCCHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCSSSSSSCHHHHHHHHHHHCCCCCCCHHHSSSCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHCCCCCCCCCSSCCCCCCCCHHHHHHHCCCCCCCSSSSCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCSSCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCSSSSCCCCHHHCCC
Confidence	9203456789999999999999985236788998899798589989996247995389995341689999856789999999999852266789999888866665321113567888878847835787479999999963899985897777888877989997119979999367762322576899999864469999999999999999729998853898547789999999808111140341010047767876577219999999999929999999999999973999999960024577666255884478899999984877898578711255310011011122221111023445432111012244201101223331133144455676422467899999999999999999997032769889999999989999879958986454379
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MERAVRVESGVLVGVVCLLLACPATATGPEVAQPEVDTTLGRVRGRQVGVKGTDRLVNVFLGIPFAQPPLGPDRFSAPHPAQPWEGVRDASTAPPMCLQDVESMNSSRFVLNGKQQIFSVSEDCLVLNVYSPAEVPAGSGRPVMVWVHGGALITGAATSYDGSALAAYGDVVVVTVQYRLGVLGFFSTGDEHAPGNQGFLDVVAALRWVQENIAPFGGDLNCVTVFGGSAGGSIISGLVLSPVAAGLFHRAITQSGVITTPGIIDSHPWPLAQKIANTLACSSSSPAEMVQCLQQKEGEELVLSKKLKNTIYPLTVDGTVFPKSPKELLKEKPFHSVPFLMGVNNHEINVPTVSFSRYLRDSGSPVFFYEFQHRPSSFAKIKPAWVKADHGAEGAFVFGGPFLMDESSRLAFPEATEEEKQLSLTMMAQWTHFARTGDPNSKALPPWPQFNQAEQYLEINPVPRAGQKF
Prediction	5430020100100001122100000032354540303054030202224143464302012202302011271413213327457211201623120103244243332224234542411000000000003525884300000000010011000110203300453200000000100000000043740100100100200020025005403012510000000000000000000020440021000000000001123550251033005304054632530041037130530141362341000000012021520230055241250200100001002011111222122222212012000001012212201100021000000000000111113022251265035205310300024030010137432742422574310302252434655
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Contact, Hydrogen and Distance Map Used in D-I-TASSER simulation

Contact Map

Distance Map

Hydrogen bond networks

D-I-TASSER simulation is guided by the consensus contact map (left figure), distance map (middle figure) and Hydrogen bond network (right figure) derived based on confidence scores of AttentionPotential. In the contact, distance map and hydrogen bond networks, the axes mark the residue index along the sequence. For the contact map, each dot represents a residue pair with predicted contact, while for the distance map and hydrogen bond network, a color scale represents a distance of 1-20+ angstroms or a angle of 0-180 degree.

Top 10 threading templates used by D-I-TASSER

Rank

PDB
hit

ID1

ID2

Cov

Norm.
Zscore

Download
alignment

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420                 440                 460

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

SS
Seq

CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCSSSSCCSSSSSSSSSSCCCCCSSSSSSCCCCCCCCCCCCCCCCCCCCCCCCCCSSCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCSSSSSSCCCCCCCCCCSSSSSSCCCCCCCCCCCCCCHHHHHHCCCSSSSSSCCCCHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCSSSSSSCHHHHHHHHHHHCCCCCCCHHHSSSCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHCCCCCCCCCSSCCCCCCCCHHHHHHHCCCCCCCSSSSCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCSSCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCSSSSCCCCHHHCCC
MERAVRVESGVLVGVVCLLLACPATATGPEVAQPEVDTTLGRVRGRQVGVKGTDRLVNVFLGIPFAQPPLGPDRFSAPHPAQPWEGVRDASTAPPMCLQDVESMNSSRFVLNGKQQIFSVSEDCLVLNVYSPAEVPAGSGRPVMVWVHGGALITGAATSYDGSALAAYGDVVVVTVQYRLGVLGFFSTGDEHAPGNQGFLDVVAALRWVQENIAPFGGDLNCVTVFGGSAGGSIISGLVLSPVAAGLFHRAITQSGVITTPGIIDSHPWPLAQKIANTLACSSSSPAEMVQCLQQKEGEELVLSKKLKNTIYPLTVDGTVFPKSPKELLKEKPFHSVPFLMGVNNHEINVPTVSFSRYLRDSGSPVFFYEFQHRPSSFAKIKPAWVKADHGAEGAFVFGGPFLMDESSRLAFPEATEEEKQLSLTMMAQWTHFARTGDPNSKALPPWPQFNQAEQYLEINPVPRAGQKF

2wqzA

0.36

0.33

9.85

1.50

DEthreader

---------------------------LAAAQYPVVNTNYGKIRGLRTPLPNILGPVEQYLGVPYASPPTGERRFQPPEPPSSWTGIRNTTQFAAVCPQHLDLFTANLDTLM--TYVQDQNEDCLYLNIYVPTEDDIHSKKPVMVYIHGGSYMEGTGNMIDGSILASYGNVIVITINYRLGILGFLSTGDQAAKGNYGLLDQIQALRWIEENVGAFGGDPKRVTIFGSGAGASCVSLLTLSHYSEGLFQKAIIQSGTALSSWAVNYQPAKYTRILADKVGCNMLDTTDMVECLRNKNYKELIQQTITPAIAFGPVIDGDVIPDDPQILMEQGEFLNYDIMLGVNQGEQWAPAVATADLHAQYGSPTYFYAFYHHCQS-EMKPSWADSAHG-DEVPYVFGIPMIGP--TELFSCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPEEVAWSRYNPDQLYLHIGLKPRVRDHA

1mx9D

0.50

0.46

13.41

3.12

SPARKS-K

------------------------------SSPPVVDTVHGKVLGKFVSLEGFAQPVAIFLGIPFAKPPLGPLRFTPPQPAEPWSFVKNATSYPPMCTQDAGQLLSELFTNRKENIPLKLSEDCLYLNIYTPADLTKKNRLPVMVWIHGGGLMVGAASTYDGLALAAHENVVVVTIQYRLGIWGFFSTGDEHSRGNWGHLDQVAALRWVQDNIASFGGNPGSVTIFGESAGGESVSVLVLSPLAKNLFHRAISESGVALTSVVKKGDVKPLAEQIAITAGCKTTTSAVMVHCLRQKTEEELLETTLKMQPLLGTVIDGMLLLKTPEELQAERNFHTVPYMVGINKQEFGVPSVIVARNHRDAGAPTYMYEFQYRPSFSSDMKPKTVIGDHGDELFSVFGAPFLKE--------GASEEEIRLSKMVMKFWANFARNGNPNGEGLPHWPEYNQKEGYLQIGANTQAAQKL

6cqtA

0.37

0.34

10.06

0.97

MapAlign

------------------------------DAELLVTVRGGRLRGIRLKT--PGGPVSAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPNRELSEDCLYLNVWTPYPR-PTSPTPVLVWIYGGGFYSGASSVYDGRFLVQAERTVLVSMNYRVGAFGFLALPSREAPGNVGLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASVGMHLLSPPSRGLFHRAVLQSGAPNGPWATVGMARRRATQLAHLVGC-PGNDTELVACLRTRPAQVLVNHEWHVLFSFVPVVDGDFLSDTPEALINAGDFHGLQVLVGVVKDEVVCPVAQLAGRLAAQGARVYAYVFEHRASTL--SWPLWMGVPHGYEIEFIFGIPLD-------PSRNYTAEEKIFAQRLMRYWANFARTGDPNE-PAPQWPPYTAAQQYVSLDLPLEVRRGL

3i6mA

0.37

0.33

9.95

0.74

CEthreader

-----------------------------DHSELLVNTKSGKVMGTRVPV--LSSHISAFLGIPFAEPPVGNMRFRRPEPKKPWSGVWNASTYPNNCQQYVDEQFPGFSGSEMWNPNREMSEDCLYLNIWVPS--PRPKSTTVMVWIYGGGFYSGSSTVYNGKYLAYTEEVVLVSLSYRVGAFGFLALHGSEAPGNVGLLDQRMALQWVHDNIQFFGGDPKTVTIFGESAGGASVGMHILSPGSRDLFRRAILQSGSPNCPWASVSEGRRRAVELGRNLNCNLNSDEELIHCLREKKPQELIDVEWNVLFSFVPVIDGEFFPTSLESMLNSGNFKKTQILLGVNKDEGSFPLMHFVNKYTKFGNGTYLYFFNHRASNLV--WPEWMGVIHGYEIEFVFGLPLV-------KELNYTAEEEALSRRIMHYWATFAKTGNPNEPHESKWPLFTTEQKFIDLNTEPMKVHQR

1mx9D

0.50

0.46

13.35

2.25

MUSTER

------------------------------SSPPVVDTVHGKVLGKFVSLEGFAQPVAIFLGIPFAKPPLGPLRFTPPQPAEPWSFVKNATSYPPMCTQDPKAGQLLLFTNRKENIPLKLSEDCLYLNIYTPADLTKKNRLPVMVWIHGGGLMVGAASTYDGLALAAHENVVVVTIQYRLGIWGFFSTGDEHSRGNWGHLDQVAALRWVQDNIASFGGNPGSVTIFGESAGGESVSVLVLSPLAKNLFHRAISESGVALTSVLVKKDVKPLAEQIAITAGCKTTTSAVMVHCLRQKTEEELLETTLKMQPLLGTVIDGMLLLKTPEELQAERNFHTVPYMVGINKQEFGVPSVIVARNHRDAGAPTYMYEFQYRPSFSSDMKPKTVIGDHGDELFSVFGAPFLK--------EGASEEEIRLSKMVMKFWANFARNGNPNGEGLPHWPEYNQKEGYLQIGANTQAAQKL

1mx9D

0.50

0.46

13.30

2.38

HHsearch

------------------------------SSPPVVDTVHGKVLGKFVSLEGFAQPVAIFLGIPFAKPPLGPLRFTPPQPAEPWSFVKNATSYPPMCTQDPKAGQLLSELFTKENIPLKLSEDCLYLNIYTPADLTKKNRLPVMVWIHGGGLMVGAASTYDGLALAAHENVVVVTIQYRLGIWGFFSTGDEHSRGNWGHLDQVAALRWVQDNIASFGGNPGSVTIFGESAGGESVSVLVLSPLAKNLFHRAISESGVALTSVLVKKDVKPLAEQIAITAGCKTTTSAVMVHCLRQKTEEELLETTLKMQPLLGTVIDGMLLLKTPEELQAERNFHTVPYMVGINKQEFGVPSVIVARNHRDAGAPTYMYEFQYRPSFSSDMKPKTVIGDHGDELFSVFGAPFL--------KEGASEEEIRLSKMVMKFWANFARNGNPNGEGLPHWPEYNQKEGYLQIGANTQAAQKL

1qo9A

0.29

0.26

7.99

3.15

FFAS-3D

-------------------------------DRLVVQTSSGPVRGRSVTV--QGREVHVYTGIPYAKPPVEDLRFRKPVPAEPWHGVLDATGLSATCVQERYEYFPGFSGEEIWNPNTNVSEDCLYINVWAPAK-NTTNGLPILIWIYGGGFMTGSATLYNADIMAAVGNVIVASFQYRVGAFGFLHLAPEEAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLFGESAGSSSVNAQLMSPVTRGLVKRGMMQSGTMNAPWSHMTSEKAVEIGKALIASMLKTNPAHVMSCMRSVDAKTISVQQWNSSFPSAPTIDGAFLPADPMTLMKTADLKDYDILMGNVRDEGTYFLTNEYAQALAERGASVHYYYFTHRTSTSLWGEWMGVLHGDEIEYF--------FGQPLNNSLQYRPVERELGKRMLSAVIEFAKTGNPAQDG-EEWPNFSKEDPYYIFSTDDKIEK--

1mx9D

0.47

0.43

12.61

1.28

EigenThreader

------------------------------SSPPVVDTVHGKVLGKFVSLEGFAQPVAIFLGIPFAKPPLGPLRFTPPQPAEPWSFVKNATSYPPMCTQDPKAGQLLSELFTNRKENIPLKEDCLYLNIYTPADLTKKNRLPVMVWIHGGGLMVGAASTYDGLALAAHENVVVVTIQYRLGIWGFFSTGDEHSRGNWGHLDQVAALRWVQDNIASFGGNPGSVTIFGESAGGESVSVLVLSPLAKNLFRAISESGVALTSVLVKKGDVKPLAEQIAITAGCKTTTSAVMVHCLRQKTEEELLETTLKMKFLLGTVIDGMLLLKTPEELQAERNFHTVPYMVGNKQEMFGVPSVIVARNHRDAGAPTYMYEFQYRPSFSSDMKPKTVIGDHGDELFSVFGAPFLKE--------GASEEEIRLSKMVMKFWANFARNGNPNGEGLPHWPEYNQKEGYLQIGNTQAAQKLK

1mx1A

0.50

0.46

13.41

4.26

CNFpred

------------------------------SSPPVVDTVHGKVLGKFVSLEGFAQPVAIFLGIPFAKPPLGPLRFTPPQPAEPWSFVKNATSYPPMCTQDPKAGQSELFTNRKENIPLKLSEDCLYLNIYTPADLTKKNRLPVMVWIHGGGLMVGAASTYDGLALAAHENVVVVTIQYRLGIWGFFSTGDEHSRGNWGHLDQVAALRWVQDNIASFGGNPGSVTIFGESAGGESVSVLVLSPLAKNLFHRAISESGVALTSVLVKKDVKPLAEQIAITAGCKTTTSAVMVHCLRQKTEEELLETTLKMKPLLGTVIDGMLLLKTPEELQAERNFHTVPYMVGINKQEFGVPSVIVARNHRDAGAPTYMYEFQYRPSFSSDMKPKTVIGDHGDELFSVFGAPFL--------KEGASEEEIRLSKMVMKFWANFARNGNPNGEGLPHWPEYNQKEGYLQIGANTQAAQKL

1mx9D

0.50

0.46

13.35

1.50

DEthreader

-----------------------------S-SPPVVDTVHGKVLGKFVSLEGFAQPVAIFLGIPFAKPPLGPLRFTPPQPAEPWSFVKNATSYPPMCTQDPKAGQLLSELT-KENIPLKLSEDCLYLNIYTPADLTKKNRLPVMVWIHGGGLMVGAASTYDGLALAAHENVVVVTIQYRLGIWGFFSTGDEHSRGNWGHLDQVAALRWVQDNIASFGGNPGSVTIFGESAGGESVSVLVLSPLAKNLFHRAISESGVALTSVLVKKDVKPLAEQIAITAGCKTTTSAVMVHCLRQKTEEELLETTLMKFPLLGTVIDGMLLLKTPEELQAERNFHTVPYMVGINKQEAGVPSVIVARNHRDAGAPTYMYEFQYRPSFSSDMKPKTVIGDHGDELFSVFGAPFLK--------EGASEEEIRLSKMVMKFWANFARNGNPNGEGLPHWPEYNQKEGYLQIGANTQAAQKL

(a)	ID1 is the number of template residues identical to query divided by number of aligned residues.
(b)	ID2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment and is highlighted in bold.
(e)	Download alignment lists the threading program used to identify the template, and provide the 3D structure of aligned regions of threading templates (threading[1-10].pdb.gz).
(f)	Template residues identical to query sequence are highlighted in color.

Top 1 final models from D-I-TASSER

Click to view	Rank^a	Download	Estimated TM-score^b
	1	model1.pdb.gz	0.7957

(a)

D-I-TASSER simulations generate a large ensemble of structural conformations, i.e. decoys. These decoys are clustered by SPICKER based on pairwise structure similarity to report up to five final models from the five largest clusters. Models are ranked in descending order of cluster size. If the simulations converge well, it is possible to have less than 5 models generated, which is usually an indication of good model quality.

(b)

The model confidence is quantitatified by estimated TM-score (eTM-score), calculated based on significance of threading template alignments, contact map satisfaction rate, mean absolute error between distance of model and distance of AttentionPotential, and convergence of D-I-TASSER simulations. eTM-score is typically in the range of [0, 1], with higher eTM-score signifies higher model confidence.

Proteins with similar structure

Top 10 structural analogs in PDB (as identified by TM-align)

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov.	Download Alignment
1	2wqzA	0.90	2.07	0.357	0.942	model1_2wqzA.pdb.gz
2	1q83A	0.89	1.42	0.365	0.917	model1_1q83A.pdb.gz
3	1mx9D	0.89	1.75	0.499	0.919	model1_1mx9D.pdb.gz
4	3i6mA	0.89	1.33	0.368	0.910	model1_3i6mA.pdb.gz
5	5x61B	0.89	1.43	0.364	0.913	model1_5x61B.pdb.gz
6	6cqtA	0.89	1.40	0.372	0.910	model1_6cqtA.pdb.gz
7	4qwwA	0.88	1.37	0.373	0.904	model1_4qwwA.pdb.gz
8	2pm8A	0.88	1.25	0.365	0.900	model1_2pm8A.pdb.gz
9	1qo9A	0.87	1.60	0.320	0.902	model1_1qo9A.pdb.gz
10	2fj0A	0.85	2.36	0.270	0.904	model1_2fj0A.pdb.gz

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov. represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted Gene Ontology (GO) Terms

Molecular Function (MF)

GO term	Cscore^GO	Name
GO:0052689	1.00	carboxylic ester hydrolase activity

Download full result of the above consensus prediction.

Click the graph to show a high resolution version.

(a)

Cscore^GO is the confidence score of predicted GO terms. Cscore^GO values range in between [0-1]; where a higher value indicates a better confidence in predicting the function using the template.

(b)

The graph shows the predicted terms within the Gene Ontology hierachy for Molecular Function. Confidently predicted terms are color coded by Cscore^GO:

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Biological Process (BP)

GO term	Cscore^GO	Name
GO:0044699	0.99	single-organism process
GO:0009987	0.98	cellular process
GO:0044763	0.97	single-organism cellular process
GO:0065007	0.96	biological regulation
GO:0050789	0.87	regulation of biological process
GO:0022607	0.87	cellular component assembly
GO:0050804	0.86	modulation of synaptic transmission
GO:0007155	0.86	cell adhesion
GO:0007158	0.85	neuron cell-cell adhesion
GO:0065008	0.72	regulation of biological quality
GO:0001505	0.69	regulation of neurotransmitter levels
GO:0050808	0.65	synapse organization
GO:0032501	0.64	multicellular organismal process
GO:0007416	0.64	synapse assembly
GO:0051179	0.62	localization
GO:0003008	0.62	system process
GO:2000463	0.61	positive regulation of excitatory postsynaptic potential
GO:2000311	0.61	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
GO:1903530	0.61	regulation of secretion by cell
GO:1902578	0.61	single-organism localization
GO:0097104	0.61	postsynaptic membrane assembly
GO:0051968	0.61	positive regulation of synaptic transmission, glutamatergic
GO:0051965	0.61	positive regulation of synapse assembly
GO:0051050	0.61	positive regulation of transport
GO:0050877	0.61	neurological system process
GO:0050773	0.61	regulation of dendrite development
GO:0048523	0.61	negative regulation of cellular process
GO:0006810	0.61	transport
GO:2000809	0.60	positive regulation of synaptic vesicle clustering
GO:2000310	0.60	regulation of N-methyl-D-aspartate selective glutamate receptor activity
GO:2000302	0.60	positive regulation of synaptic vesicle exocytosis
GO:1902533	0.60	positive regulation of intracellular signal transduction
GO:1902474	0.60	positive regulation of protein localization to synapse
GO:1900244	0.60	positive regulation of synaptic vesicle endocytosis
GO:1900029	0.60	positive regulation of ruffle assembly
GO:0097120	0.60	receptor localization to synapse
GO:0097119	0.60	postsynaptic density protein 95 clustering
GO:0097115	0.60	neurexin clustering involved in presynaptic membrane assembly
GO:0097114	0.60	NMDA glutamate receptor clustering
GO:0097113	0.60	AMPA glutamate receptor clustering
GO:0072553	0.60	terminal button organization
GO:0061002	0.60	negative regulation of dendritic spine morphogenesis
GO:0060999	0.60	positive regulation of dendritic spine development
GO:0060291	0.60	long-term synaptic potentiation
GO:0060080	0.60	inhibitory postsynaptic potential
GO:0051491	0.60	positive regulation of filopodium assembly
GO:0051262	0.60	protein tetramerization
GO:0051260	0.60	protein homooligomerization
GO:0048789	0.60	cytoskeletal matrix organization at active zone
GO:0032230	0.60	positive regulation of synaptic transmission, GABAergic
GO:0016339	0.60	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
GO:0016080	0.60	synaptic vesicle targeting
GO:0010841	0.60	positive regulation of circadian sleep/wake cycle, wakefulness
GO:0007157	0.60	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
GO:0006605	0.60	protein targeting
GO:0002087	0.60	regulation of respiratory gaseous exchange by neurological system process
GO:0051290	0.59	protein heterotetramerization
GO:0045161	0.59	neuronal ion channel clustering
GO:0008152	0.54	metabolic process
GO:0071704	0.53	organic substance metabolic process
GO:0044237	0.53	cellular metabolic process
GO:0044710	0.52	single-organism metabolic process
GO:0009056	0.52	catabolic process
GO:1901575	0.51	organic substance catabolic process
GO:0044712	0.51	single-organism catabolic process
GO:0044248	0.51	cellular catabolic process
GO:0006807	0.50	nitrogen compound metabolic process

Download full result of the above consensus prediction.

Click the graph to show a high resolution version.

(a)

Cscore^GO is the confidence score of predicted GO terms. Cscore^GO values range in between [0-1]; where a higher value indicates a better confidence in predicting the function using the template.

(b)

The graph shows the predicted terms within the Gene Ontology hierachy for Biological Process. Confidently predicted terms are color coded by Cscore^GO:

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Cellular Component (CC)

GO term	Cscore^GO	Name
GO:0005615	0.99	extracellular space
GO:0044464	0.66	cell part
GO:0045202	0.50	synapse

Download full result of the above consensus prediction.

Click the graph to show a high resolution version.

(a)

Cscore^GO is the confidence score of predicted GO terms. Cscore^GO values range in between [0-1]; where a higher value indicates a better confidence in predicting the function using the template.

(b)

The graph shows the predicted terms within the Gene Ontology hierachy for Cellular Component. Confidently predicted terms are color coded by Cscore^GO:

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted Enzyme Commission (EC) Numbers

Top 5 enzyme homologs in PDB

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov.	EC Number	Predicted Active Site Residues
1	0.183	1mx9D	0.889	1.75	0.499	0.919	3.1.1.1	NA
2	0.176	1b41A	0.884	1.33	0.374	0.906	3.1.1.7	NA
3	0.175	1maaD	0.888	1.40	0.367	0.913	3.1.1.7	NA
4	0.173	2pm8A	0.880	1.25	0.365	0.900	3.1.1.8	NA
5	0.171	1k4yA	0.850	1.77	0.473	0.878	3.1.1.1	NA

	Click on the radio buttons to visualize predicted active site residues.
(a)	Cscore^EC is the confidence score for the Enzyme Commission (EC) number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov. represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted Ligand Binding Sites

Template proteins with similar binding site:

Click to view	Rank	Cscore^LB	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov.	BS-score	Lig. Name	Download Complex	Predicted binding site residues
	1	0.07	1ku60	0.890	1.42	0.366	0.915	0.41	III	complex1.pdb.gz	98,100,101,120
	2	0.07	2y2vA	0.886	1.41	0.365	0.910	0.40	P15	complex2.pdb.gz	73,74,182,186

	Click on the radio buttons to visualize predicted binding site and residues.
(a)	Cscore^LB is the confidence score of predicted binding site. Cscore^LB values range in between [0-1]; where a higher score indicates a more reliable ligand-binding site prediction.
(b)	BS-score is a measure of local similarity (sequence & structure) between template binding site and predicted binding site in the query structure. Based on large scale benchmarking analysis, we have observed that a BS-score >1 reflects a significant local match between the predicted and template binding site.
(c)	TM-score is a measure of global structural similarity between query and template protein.
(d)	RMSD^a the RMSD between residues that are structurally aligned by TM-align.
(e)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(f)	Cov. represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

[Click result.zip to download all results on this page]

References:
1.	Wei Zheng, Chengxin Zhang, Yang Li, Robin Pearce, Eric W. Bell, Yang Zhang. Folding non-homology proteins by coupling deep-learning contact maps with I-TASSER assembly simulations. In preparation, 2020.