D-I-TASSER Q13316-D1

D-I-TASSER results for Q13316-D1

[Click result.zip to download all results on this page]

Input Sequence in FASTA format

>Q13316 (513 residues)
MKISILLMFLWGLSCALPVTRYQNNESEDSEEWKGHLAQAPTPPLESSESSEGSKVSSEE
QANEDPSDSTQSEEGLGSDDHQYIYRLAGGFSRSTGKGGDDKDDDEDDSGDDTFGDDDSG
PGPKDRQEGGNSRLGSDEDSDDTIQASEESAPQGQDSAQDTTSESRELDNEDRVDSKPEG
GDSTQESESEEHWVGGGSDGESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSK
ESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSN
SRDTGLSQPRRDSKGDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSSESQEEVV
SESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEESPE
SPEDENSSSQEGLQSHSSSAESQSEESHSEEDDSDSQDSSRSKEDSNSTESKSSSEEDGQ
LKNIEIESRKLTVDAYHNKPIGDQDDNDCQDGY

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 480 500 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MKISILLMFLWGLSCALPVTRYQNNESEDSEEWKGHLAQAPTPPLESSESSEGSKVSSEEQANEDPSDSTQSEEGLGSDDHQYIYRLAGGFSRSTGKGGDDKDDDEDDSGDDTFGDDDSGPGPKDRQEGGNSRLGSDEDSDDTIQASEESAPQGQDSAQDTTSESRELDNEDRVDSKPEGGDSTQESESEEHWVGGGSDGESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKGDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEESPESPEDENSSSQEGLQSHSSSAESQSEESHSEEDDSDSQDSSRSKEDSNSTESKSSSEEDGQLKNIEIESRKLTVDAYHNKPIGDQDDNDCQDGY
Prediction	CCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCC
Confidence	972238999875220341111246766662002466667888765555443334665312367887766655445777777642367888666777665567654446777765556689887655567877667776667777766666655445666677644345656565556566776655555444567888776777776554666666788764456666666566775544456765556667777543445677543323456633467777766653212356666677666666667666665455676555676667777787654444567655554432233334556677877666666666555432245667876666654322234556655676556777765555432345555665333334333333333333433223355677666676555676654442000000110146657765543333479
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 480 500 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MKISILLMFLWGLSCALPVTRYQNNESEDSEEWKGHLAQAPTPPLESSESSEGSKVSSEEQANEDPSDSTQSEEGLGSDDHQYIYRLAGGFSRSTGKGGDDKDDDEDDSGDDTFGDDDSGPGPKDRQEGGNSRLGSDEDSDDTIQASEESAPQGQDSAQDTTSESRELDNEDRVDSKPEGGDSTQESESEEHWVGGGSDGESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKGDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEESPESPEDENSSSQEGLQSHSSSAESQSEESHSEEDDSDSQDSSRSKEDSNSTESKSSSEEDGQLKNIEIESRKLTVDAYHNKPIGDQDDNDCQDGY
Prediction	630000000001100000002235465544653555556345454554544555645555455645565553565345654433323443235543564556456546445344445762544564554654445454555544445654455555456544444454566554544566555455454445425454554445443353455534454454463654524465453545556555565446545444444444443345453455555544754444544555455545465564554545455555555765545654664754465346655566556545356544644554456655655555555545556546555555465555555465564555665566456655456555465645555565555556655555565454665665655534566555565454544434243342464456445436637
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Contact, Hydrogen and Distance Map Used in D-I-TASSER simulation

Contact Map

Distance Map

Hydrogen bond networks

D-I-TASSER simulation is guided by the consensus contact map (left figure), distance map (middle figure) and Hydrogen bond network (right figure) derived based on confidence scores of AttentionPotential. In the contact, distance map and hydrogen bond networks, the axes mark the residue index along the sequence. For the contact map, each dot represents a residue pair with predicted contact, while for the distance map and hydrogen bond network, a color scale represents a distance of 1-20+ angstroms or a angle of 0-180 degree.

Top 10 threading templates used by D-I-TASSER

Rank

PDB
hit

ID1

ID2

Cov

Norm.
Zscore

Download
alignment

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420                 440                 460                 480                 500

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

SS
Seq

CCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCC
MKISILLMFLWGLSCALPVTRYQNNESEDSEEWKGHLAQAPTPPLESSESSEGSKVSSEEQANEDPSDSTQSEEGLGSDDHQYIYRLAGGFSRSTGKGGDDKDDDEDDSGDDTFGDDDSGPGPKDRQEGGNSRLGSDEDSDDTIQASEESAPQGQDSAQDTTSESRELDNEDRVDSKPEGGDSTQESESEEHWVGGGSDGESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKGDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEESPESPEDENSSSQEGLQSHSSSAESQSEESHSEEDDSDSQDSSRSKEDSNSTESKSSSEEDGQLKNIEIESRKLTVDAYHNKPIGDQDDNDCQDGY

5jcss

0.08

3.03

2.15

SPARKS-K

GKTFLINELSKYMGCHDSIVKIHLGEQTDAKLLIGTYTSGDKPGTDIDKAPTDVLSILLSLLEKRELTIPSRGETVKAANGFQLIS-TVRINEDHQKDSSNKIYNLNMIGMRIWNVELEEPSEEDLTHILAQKFPILTNLIPKLIDKSIYMNTKFISLNKGAHTRRDLCERLDILFKNNGINKPDQLIQSSVYDSIFSEAADCFAGAIGEFKALE-----PIIQAIGESLDIASSR---ISLFLTQHVPTLENLDDSIKIGRAVLLKEKLNIQKKSMNSTLFAFTNHSLRLMEQISVCIQMTEPVVGETGTGKTTVVQQLA---KMLAKKLTVINVSQQT--ETGDPKTVAVPIQENFETLFNATFSLKKNEKFHKMHRCFNKNQWKNVVKLWNEAYKMAQSILKITNTENENENAKKKKRRLNTHEKKLLLDKWADFNDSVKKFEAQSSSIENSFVEGSLVKTDEVNLATADTLETEPDSRSILLSEKGDAEPIKHPDFRIFACMNPATDVG

5wlcLT

0.06

2.63

1.37

MapAlign

--FATGTLGSTFYIVTCVGKTFQIYDANTLHLLFVSEKETPSSIVALSAHFHYVYAAYENKVGIYKRGIEEHLLELETDANVEHLCIFGDYLCASTDDNSIFIYKKSQDKYPSEFYTKLTVTEIQGGEIVSLQHLATYLNKLTVVTKSNVLLFNVRTGKLVFTSNEFPDQITTAEPAPVLDIIALGTVTGEVIMFNMRKGKRIRTIKISSLSFRTDGSSHLSVGTSSGDLIFYDLVLKNIHRESYGGVTQATFLNGQPIIVTSGGDNSLKEYVFDPSLSQGSGDVVVQPPRYLRSRGGHSQPPSYIAFADSQSHFMLSASKDRSLWSFSLRKDAQSQEMSQRLHKKQDGGRVGGSTIKSKFPEIVALAIENARIGEWENIITARTWDMRNKRVGRWTFDTTDDGFVKSVAMSQCGNFGFIGSSNGSITIYNMQSGILRKKYKLHKRAVTGISLDGMNRKMVSCGLDGIVGFYDFNKSTLLGKLKLDAPITAMVYHRSSDLFALALDDLSIVVI

1e07A

0.11

3.81

1.21

MUSTER

FNVAVLLLV--NLPQHLFGYSYKGERVDGNRQIIGYVIGTQQATPGPAYSGREIIYPNAS-QNIIQNDTGFIKSDLVNEEATGQFRVYPELPKPSISSNNSKPVEDKDA---AFTCEPETQDATQSLPVSPRLQLSNGNRT-FNVTRNDTASETQNPVSARRSDSVILNVLYGPDAPTISPLNTSYRSGENLNLSCHAASNPPAQNGTFQQSTQELF--PNITVNNSGSYTCQAHNSDTGLNRTTVTTITVYAEPPKPFITSNNSNPVEDEDAVALTCEPEIQNTTYLWWVNNQSLPVSPRLQLSNDNRTLTLLSVTRNDVQNELSVDHSDPVILNVLYGPDDPTISPSYTYYRPGVNLS-HAASNPPAQYSWLIDGNIQQHTQE--FISNITEKNSQANNSASGHSRTTVKTITVSAELPKPSISSNNSKPVEDKDAVATCEPEAQNTTNGQSLPVSPRLQLSNGNRT--FNVTRNDAQNSVSANRSDPVTLDVLYDTPIISPPDSSYLSGA

5wlcLT

0.08

3.01

0.64

CEthreader

------------------------KNSKIFSPFRIIGNVSNGVPFATGTLGSTFYIVTCVGKTFQIYDANTLHLLFVSETPSSIVALSAHFHYVYAAYENKVGIYKRGIEEHLLELETDANVEHLCIFGDYLCASTDDNSIFIYKKSDPQDKYPSEFYTKLTVTEIQGGEIVSLQHLATYLNKLTVVTKSNNVRTGKLVFTSNEFPDQITTAEPAPVLDIIALGTVTGEVIMFNMRKGKKIPQSRISSLSFRTDGSSHLSVGTSSGDLIFYDLDRRSRIHVLKNIHRESYGGVTQATFLNGQPIIVTSGGDNSLKEYVFDPSLSQGSGDVVVQPPRYLRSRGGHSQPPSYIAFADSQSHFMLSASKDRSLWSFSLRKDAQSQEMSQRLHKKQDGGRVGGSTIKSKFPEIVALAIENARIGEWENIITAHKDEKFARTWDMRNKRVGRWTFDTTDDGFVKSVAMSQCGNFGFIGSSNGSITIYNMQSGILRKKYKLHKRAVTGISLDGMNRKMV

5vkqA

0.06

2.67

0.67

EigenThreader

MDRMIELGADVGARNNDNMYSREDVVKLLLTKRGVD-----PFSTGGSRSQTAVHLVSSRQTGTATNILRALLAAAGKDIRLKA--DGRGKIPLLLAVESGNQSMCRELLAAQTAEQLKATTANGDTALHLAARRRDVDMVRILVDYGTNVDTQNGEGQTPLHIAAAEGDVRASASIADNQDRTPMHLAAENGHAHVIEILADKFKASIFERTKDGSTLMHIASLNGHAECATMLFKKGVYLHMPNKDGARSIHTAAAYGHTGIINTLLQKGEKVDVTTNDNYTALHIAVESAKPAVVETLLGFGADVHVRGGKLRETPLHIAARVK--DGDRCALMLLKSGASPNLTTDDCLTPVHVAARHGNTDDLGQKHPSLVNATSKDGNTSARNKLTDATPLQLAAEGGDVVKALVRAGASCTEENKAGFTAVHLAAQNGHGQVLDVLKSTNSLRINSKKLGLTPLHVAAYYGQADTVRELLTSVPATHLAAFSGNRLLLNSAGVQVDAATIENGYNP

6hwhX

0.20

0.03

0.87

0.33

FFAS-3D

MHIEARLFEILTAFFALAAVVYTAMFATGGVEWAGFFRFVARRLDTRPEDYEDA--EISDGAGELGFFAPHS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

6em5m

0.11

0.09

3.30

1.77

SPARKS-K

---------------------------------------------YSKYADGSDRIIKPEINPVYDSDDSDAETQNTIDEMPHIGYDINGMRPAKGSALDQLLDSIELP--------EGWTGLLDKNSGSSLNL-TKEELELISKIQRNEQTDDSINPYEPLIDWFTRHEEVMPLTVPEPKRRFVPSKNEAKRVGRIIPPKKLKEMKEK-------------EKIENYQYDLWGDSTETNDHVMHLRAPKLPPPTNEESYNPP-----------EEYLLSPEEKEAWENTEYSERERNFIPQKYSALRKVPGYGESIRERFERSLDLYLAPRVRKN----KLNIDPNSLIPELPSPKDLRP-----FPIRCSTIYAGHKGKVRTLSIDPSATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYHIECIEWNPDANNGILAVAVGENVPPIFGYDIENNGKTEDGFAQWNKPSQKQLEKDICITISCKKTVKKLSWHRK--GDYFVTVQPDSG

6g7eB

0.09

0.06

2.19

0.67

DEthreader

---------DVAT-V-------------D--QW-DDAYRLCVLDKFTDYSSDTSVAPIETVGQTLAVLRHISVESVHA--IY-LLYCVTQEGLVVKDLLQDGDIDGVVRCVQ---------TLIPAKEFVRR----------------SASTGKIDLLATL------------------L-PFLRHTITSVRLA-L-------QNIIVERDQ--------NSLELWLHAPLALHPIGVPRH----------------EVDGVLIRRIAAKAGLISFIPTPRLASYDTAVLQ-A-LSSPYASTQ------A--A-IDEYACSTPEVASRFIEPLQAALVAELQSRR---VGD--AT-VK------------LCDDGLGKTLQTVLRLILTGTPIQNNE-------DLSDLQRKLFEDTKGITEAGRDIFALQYRKLCNSPALELVTFVEHDWNPITLE--------------------------------------------------------

5wyjBE

0.05

2.35

1.34

MapAlign

---FATGTLGSTFYIVTCGKTFQIYDANTLHLLFVSEKETPSSIVALSAHFHYVYAAYENKVGIYKRGIEEHLLELETDANVEHLCIFGDYLCASTDDNSIFIYKQGGEIVSLQHLATYLNKLTVVTKSNVLLFNVRTGKLVFTSNEFPDQITTAEPAPVLDIIALGTVTGEVIFRTDGSSHLSVGTSSGDLIFYDLDRRSRIHVLKNIHRESYGGVTQATFLNGQPIIVTSGGDNSLKEY---------VFDPQPPRYLRSRGGHSQPPSYIAFADSQSHFMLSASKDRSLWSFSLRKDAQSQEMSQRSKFPEIVALAIENARIGEWENIITAHKDEKFARTWDMRNKRVGRWTFDTTDDGFVKSVAMSQCGNFGFIGSSNGSITIYNMQSGILRKKYKLHKRAVTGISLDGMNRKMVSCGLDGIVGFYDFNKSTLLGKLKLDAPITAMVYHRSSDLFALALDDLSIVVIDAVTQRVVRQLWGHSNRITAFDFSPEGRWIVSASLDSTIRTW

1zvoC

0.10

0.09

3.20

1.21

MUSTER

--------------------RLQLQESGPGLVKPSEIVSGGPIRRTGYYQPPGKGLEWIGGVYYTGSIYYNPSLRGRVTISVDTSRNQFSLNLRSMSAADTAM-----GNPPPYYDIGTGSDDGIDVWGQGTTVHVSSAPTKAPDVFPIISGCRHPKDNSPVVLITGYHPTSYMGTQSQPQRTFPEIQRRDSYYMTSS-TPLQQWRQGEYK---VVQHTASKSKKEIFRWPESPKAQASSVPTAQPQAEGSLAKATTAPATTRNTGRGGEEKKKEKEKEEQEERETKTPECPSHTQPLGVYLLTPAVQDWLRDKATVGSDLKDAHEVAGKVPTGGVEEGLLERHSNGSQSQHSRLTLPRSLWNAGNHPSLPPQRLMALREPAAQAPVKLSLNLLASSDPPEASGFSPPNILLMWLEDQREVNTSGFAPARPPPQPGSTTFWAWSVPAPPSPQPATSHEDSRTLLNASRSLEVSYVTDHGPM--------------------------------

(a)	ID1 is the number of template residues identical to query divided by number of aligned residues.
(b)	ID2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment and is highlighted in bold.
(e)	Download alignment lists the threading program used to identify the template, and provide the 3D structure of aligned regions of threading templates (threading[1-10].pdb.gz).
(f)	Template residues identical to query sequence are highlighted in color.

Top 1 final models from D-I-TASSER

Click to view	Rank^a	Download	Estimated TM-score^b
	1	model1.pdb.gz	0.4951

(a)

D-I-TASSER simulations generate a large ensemble of structural conformations, i.e. decoys. These decoys are clustered by SPICKER based on pairwise structure similarity to report up to five final models from the five largest clusters. Models are ranked in descending order of cluster size. If the simulations converge well, it is possible to have less than 5 models generated, which is usually an indication of good model quality.

(b)

The model confidence is quantitatified by estimated TM-score (eTM-score), calculated based on significance of threading template alignments, contact map satisfaction rate, mean absolute error between distance of model and distance of AttentionPotential, and convergence of D-I-TASSER simulations. eTM-score is typically in the range of [0, 1], with higher eTM-score signifies higher model confidence.

Proteins with similar structure

Top 10 structural analogs in PDB (as identified by TM-align)

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov.	Download Alignment
1	5wlcLT	0.95	2.09	0.062	1.000	model1_5wlcLT.pdb.gz
2	5oqlO	0.88	2.67	0.058	0.957	model1_5oqlO.pdb.gz
3	5wyjBE	0.87	2.64	0.058	0.947	model1_5wyjBE.pdb.gz
4	4nsxA	0.86	2.78	0.058	0.947	model1_4nsxA.pdb.gz
5	5oqlA	0.77	3.73	0.053	0.912	model1_5oqlA.pdb.gz
6	6n8pA	0.72	4.60	0.042	0.918	model1_6n8pA.pdb.gz
7	2oajA	0.71	4.96	0.055	0.924	model1_2oajA.pdb.gz
8	5i2tA	0.70	4.60	0.081	0.891	model1_5i2tA.pdb.gz
9	6jp6A	0.68	5.08	0.071	0.891	model1_6jp6A.pdb.gz
10	1pevA	0.68	5.09	0.073	0.885	model1_1pevA.pdb.gz

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov. represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted Gene Ontology (GO) Terms

Molecular Function (MF)

GO term	Cscore^GO	Name
GO:0046872	0.57	metal ion binding
GO:0044877	0.54	macromolecular complex binding
GO:0005509	0.53	calcium ion binding
GO:0005102	0.53	receptor binding
GO:0005178	0.52	integrin binding

Download full result of the above consensus prediction.

Click the graph to show a high resolution version.

(a)

Cscore^GO is the confidence score of predicted GO terms. Cscore^GO values range in between [0-1]; where a higher value indicates a better confidence in predicting the function using the template.

(b)

The graph shows the predicted terms within the Gene Ontology hierachy for Molecular Function. Confidently predicted terms are color coded by Cscore^GO:

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Biological Process (BP)

GO term	Cscore^GO	Name
GO:0009987	0.88	cellular process
GO:0044699	0.76	single-organism process
GO:0044763	0.72	single-organism cellular process
GO:0016043	0.69	cellular component organization
GO:0030198	0.66	extracellular matrix organization
GO:0065007	0.63	biological regulation
GO:0050789	0.61	regulation of biological process
GO:0070167	0.50	regulation of biomineral tissue development

Download full result of the above consensus prediction.

Click the graph to show a high resolution version.

(a)

Cscore^GO is the confidence score of predicted GO terms. Cscore^GO values range in between [0-1]; where a higher value indicates a better confidence in predicting the function using the template.

(b)

The graph shows the predicted terms within the Gene Ontology hierachy for Biological Process. Confidently predicted terms are color coded by Cscore^GO:

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Cellular Component (CC)

GO term	Cscore^GO	Name
GO:0044464	0.94	cell part
GO:0044424	0.91	intracellular part
GO:0044446	0.78	intracellular organelle part
GO:0043226	0.78	organelle
GO:0043229	0.77	intracellular organelle
GO:0044428	0.75	nuclear part
GO:0043227	0.75	membrane-bounded organelle
GO:0043231	0.74	intracellular membrane-bounded organelle
GO:0005634	0.72	nucleus
GO:0005730	0.67	nucleolus
GO:0044421	0.66	extracellular region part
GO:0005578	0.65	proteinaceous extracellular matrix

Download full result of the above consensus prediction.

Click the graph to show a high resolution version.

(a)

Cscore^GO is the confidence score of predicted GO terms. Cscore^GO values range in between [0-1]; where a higher value indicates a better confidence in predicting the function using the template.

(b)

The graph shows the predicted terms within the Gene Ontology hierachy for Cellular Component. Confidently predicted terms are color coded by Cscore^GO:

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted Enzyme Commission (EC) Numbers

Top 5 enzyme homologs in PDB

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov.	EC Number	Predicted Active Site Residues
1	0.066	2h47H	0.460	3.29	0.060	0.520	1.4.99.4	NA
2	0.060	1eurA	0.347	4.71	0.044	0.441	3.2.1.18	NA
3	0.060	1lrwA	0.461	4.63	0.050	0.577	1.1.99.8	366
4	0.060	1r9mB	0.435	6.54	0.034	0.632	3.4.14.5	NA
5	0.060	1w6sC	0.458	4.85	0.048	0.581	1.1.99.8	366

	Click on the radio buttons to visualize predicted active site residues.
(a)	Cscore^EC is the confidence score for the Enzyme Commission (EC) number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov. represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted Ligand Binding Sites

Template proteins with similar binding site:

Rank	Cscore^LB	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov.	BS-score	Lig. Name	Download Complex	Predicted binding site residues
1	0.01	1sqj0	0.641	5.38	0.059	0.850	0.40	III	complex1.pdb.gz	196,197,198,199,200
2	0.01	3gvkA	0.469	5.61	0.057	0.633	0.40	UUU	complex2.pdb.gz	84,94,96,97,99,127,145,250
3	0.01	2c25A	0.468	4.27	0.052	0.577	0.60	SIA	complex3.pdb.gz	77,82,96,97,98,101

	Click on the radio buttons to visualize predicted binding site and residues.
(a)	Cscore^LB is the confidence score of predicted binding site. Cscore^LB values range in between [0-1]; where a higher score indicates a more reliable ligand-binding site prediction.
(b)	BS-score is a measure of local similarity (sequence & structure) between template binding site and predicted binding site in the query structure. Based on large scale benchmarking analysis, we have observed that a BS-score >1 reflects a significant local match between the predicted and template binding site.
(c)	TM-score is a measure of global structural similarity between query and template protein.
(d)	RMSD^a the RMSD between residues that are structurally aligned by TM-align.
(e)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(f)	Cov. represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

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References:
1.	Wei Zheng, Chengxin Zhang, Yang Li, Robin Pearce, Eric W. Bell, Yang Zhang. Folding non-homology proteins by coupling deep-learning contact maps with I-TASSER assembly simulations. In preparation, 2020.