D-I-TASSER Q12767-D1

D-I-TASSER results for Q12767-D1

[Click result.zip to download all results on this page]

Input Sequence in FASTA format

>Q12767 (454 residues)
MDLKEKHLGEPPSALGLSTRKALSVLKEQLEAVLEGHLRERKKCLTALRPGQESFASLRG
IKDDEHIVLEPGDLFPPFSPPPSPRGEVERGPQSPQQHRLFRVLETPVIDNIRWCLDMAL
SRPVTALDNERFTVQSVMLHYAVPVVLAGFLITNALRFIFSAPGVTSWQYTLLQLQVNGV
LPILPLLFPVLWVLATACGEARVLAQMSKASPSSLLAKFSEDTLSSYTEAVSSQEMLRCI
WGHFLRVLGGTSPTLSHSSSLLHSLGSVTVLCCVDKQGILSWPNPSPETVLFFSGKVEPP
HSSHEDLTDGLSTRSFCHPEPHERDALLAGSLNNTLHLSNEQERGDWPGEAPKPPEPYSH
HKAHGRSKHPSGSNVSFSRDTEGGEEEPSKTQPGMESDPYEAEDFVCDYHLEMLSLSQDQ
QNPSCIQFDDSNWQLHLTSLKPLGLNVLLNLCDA

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MDLKEKHLGEPPSALGLSTRKALSVLKEQLEAVLEGHLRERKKCLTALRPGQESFASLRGIKDDEHIVLEPGDLFPPFSPPPSPRGEVERGPQSPQQHRLFRVLETPVIDNIRWCLDMALSRPVTALDNERFTVQSVMLHYAVPVVLAGFLITNALRFIFSAPGVTSWQYTLLQLQVNGVLPILPLLFPVLWVLATACGEARVLAQMSKASPSSLLAKFSEDTLSSYTEAVSSQEMLRCIWGHFLRVLGGTSPTLSHSSSLLHSLGSVTVLCCVDKQGILSWPNPSPETVLFFSGKVEPPHSSHEDLTDGLSTRSFCHPEPHERDALLAGSLNNTLHLSNEQERGDWPGEAPKPPEPYSHHKAHGRSKHPSGSNVSFSRDTEGGEEEPSKTQPGMESDPYEAEDFVCDYHLEMLSLSQDQQNPSCIQFDDSNWQLHLTSLKPLGLNVLLNLCDA
Prediction	CCHHHHHCCCCCCCCCCCCCSSSSSSSCCSSSSCCHHHSSCCCSSSSSCCCCSCCSSSSSSCCCCCSSSCCCCSCCCCCCCCCCCCCCCCCCCCCCCCSSSSSSCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHSSSCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCSSSSSSCCCCCCCCCCCCCCSSSSSCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCSSSSCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCSSSSSCCCCCCCCCCSSCCCCHHHHCCCCCCHHHHHHHHCCCC
Confidence	9624653268864468887515899978948970231144377389963982113467996489854525883416767898864321123457888727999817617899999998641898577889999999999999999999999998762033268877555678999999999988889999999999999999999863112111112211124565433445313578999999999817877675310188874012024676277410478998120897358988877764333456544446787764222334553112103433355667788888754332000244212577655335420466777764300024455543344333331110012013678886522047416664124661348988732589
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MDLKEKHLGEPPSALGLSTRKALSVLKEQLEAVLEGHLRERKKCLTALRPGQESFASLRGIKDDEHIVLEPGDLFPPFSPPPSPRGEVERGPQSPQQHRLFRVLETPVIDNIRWCLDMALSRPVTALDNERFTVQSVMLHYAVPVVLAGFLITNALRFIFSAPGVTSWQYTLLQLQVNGVLPILPLLFPVLWVLATACGEARVLAQMSKASPSSLLAKFSEDTLSSYTEAVSSQEMLRCIWGHFLRVLGGTSPTLSHSSSLLHSLGSVTVLCCVDKQGILSWPNPSPETVLFFSGKVEPPHSSHEDLTDGLSTRSFCHPEPHERDALLAGSLNNTLHLSNEQERGDWPGEAPKPPEPYSHHKAHGRSKHPSGSNVSFSRDTEGGEEEPSKTQPGMESDPYEAEDFVCDYHLEMLSLSQDQQNPSCIQFDDSNWQLHLTSLKPLGLNVLLNLCDA
Prediction	7634553264232213143320000034421130111012444100001143402030331357621303542314242424554432352234325410010031111520240043037313313430110000001200000000000100000000125433201100001101000011023301000001000102010204323545445524544354444424343203101310020024445204201200110000000000144100122221021000013555445444553444454453545534554344543333013022543445355641445533533534444344324302123244445644343444044442445322341202013033346343304142550451040010000000033158
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Contact, Hydrogen and Distance Map Used in D-I-TASSER simulation

Contact Map

Distance Map

Hydrogen bond networks

D-I-TASSER simulation is guided by the consensus contact map (left figure), distance map (middle figure) and Hydrogen bond network (right figure) derived based on confidence scores of AttentionPotential. In the contact, distance map and hydrogen bond networks, the axes mark the residue index along the sequence. For the contact map, each dot represents a residue pair with predicted contact, while for the distance map and hydrogen bond network, a color scale represents a distance of 1-20+ angstroms or a angle of 0-180 degree.

Top 10 threading templates used by D-I-TASSER

Rank

PDB
hit

ID1

ID2

Cov

Norm.
Zscore

Download
alignment

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420                 440

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

SS
Seq

CCHHHHHCCCCCCCCCCCCCSSSSSSSCCSSSSCCHHHSSCCCSSSSSCCCCSCCSSSSSSCCCCCSSSCCCCSCCCCCCCCCCCCCCCCCCCCCCCCSSSSSSCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHSSSCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCSSSSSSCCCCCCCCCCCCCCSSSSSCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCSSSSCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCSSSSSCCCCCCCCCCSSCCCCHHHHCCCCCCHHHHHHHHCCCC
MDLKEKHLGEPPSALGLSTRKALSVLKEQLEAVLEGHLRERKKCLTALRPGQESFASLRGIKDDEHIVLEPGDLFPPFSPPPSPRGEVERGPQSPQQHRLFRVLETPVIDNIRWCLDMALSRPVTALDNERFTVQSVMLHYAVPVVLAGFLITNALRFIFSAPGVTSWQYTLLQLQVNGVLPILPLLFPVLWVLATACGEARVLAQMSKASPSSLLAKFSEDTLSSYTEAVSSQEMLRCIWGHFLRVLGGTSPTLSHSSSLLHSLGSVTVLCCVDKQGILSWPNPSPETVLFFSGKVEPPHSSHEDLTDGLSTRSFCHPEPHERDALLAGSLNNTLHLSNEQERGDWPGEAPKPPEPYSHHKAHGRSKHPSGSNVSFSRDTEGGEEEPSKTQPGMESDPYEAEDFVCDYHLEMLSLSQDQQNPSCIQFDDSNWQLHLTSLKPLGLNVLLNLCDA

6lcpA

0.07

0.06

2.40

1.18

MapAlign

PIFGGVNPGLNSVPLIVIITVTAIKDAIEDYRRTILDIELNNDDELDIIILATGACYVETKNLDGETLKVRQARTLKGAIRWKEPREMSEPIGIDNLLLGCHLRNTTGHDTKIMMNAGITPSKRARIARELNFNVICNFGILLIMCLIAAIANGIAWGFEYGSIGGTPALTGFITFWAAVVIREEIAAAKVRAIRGLREYLTEHFMLALALCHTVVAEKQPGDPPKMIFKAQSPDEAALVAARDGFTGINVNVMGKDMHFPVNSSRKRMSTIVRMPDGRILLFCKGAVEGLRTLCIAERELSEEEY------------------------------------------------------------------REWRREHDLAATALENREEKLEEVADKIERDLTLLGGTAIENFIGDIQEADVGVGIQFRFLQRLVLVHVITINGYILINTYR

7ky5A

0.11

0.08

2.99

2.05

HHsearch

HNFILLILGAQIFVTNGFASVPLIVIITAIKDGIEDSRRTVVGDIVRVHNNDEIPADMILLSTSDVCYVEDGETNLKVRQGPHALLLRGC--TLRNTKAMGMVIFTGDDTKIMINAG-VTPTKKSRISRELNFSVI----LNFVLLFILCFTAGIVNGVYYKQKSTNGFVSFWV-AVILYQSLVPISLYISVEIIKTAQAIFIYTDVLLYNAK------------------------------------LDYPCTPKSWNISDDLGQIEYIFS-DKTGTLTQNVMEFKKCTINGVSYGRAYTEAL---AGLR-----------------------VDVESE-------G--------R----------REKEE---IAK---DRE---------------------TMIDELRSMSDNTQFCPEDLTFVSKEIVEDLKGSSGEHFLLALALCHS

7bgyB

0.10

0.09

3.23

0.66

CEthreader

EGRSKAQANSLKGVKKTAFARKLREPKYGAAADKVPADQLRKGDIVLVEAGDIIPCDGEVIEGGASVDESAGEAAPVIRESGGDFASVTGGTRILSDWLVIECSVNPGETFLDRMIAMVEGAQ-----RRKTPNEIALTILLIALTIVFLLATATLWPFSAWGGNAVSVTVLVALLVCLIP--------------------TTIGGLLSAIGVAGMSRMLGANVIATSGRAVEAAGD-------------------------------VDVLLLDKTGTITLGNRQASEFIPAQGVDEKTLADAAQLASLADE----TPEGRSIVILAKQRFNLRERDVQSLHATFVPFTAQSRMSGINIDNRMIRKGSVDAIRRHVEANGGHFPTDVDQKVDQVARQGATPLVVVEGSRVLGVIALKDIVKG--------GIKERFAQLRKMGIKTVMITGDN

1mhsA

0.06

2.49

0.78

EigenThreader

VVPEDMLQTDTRVGLTSEEVVQRRRKYGFVQEFQAGSIVDEPGDILQVEEGTIIPADGRIVD-AFLQVDQSALTGESLAVDKHKGDQVFASSAVKRGEAFVVITATGDNT------FVGRAAALVNAASGGSGHFTEVLNGIGTILLILVIFTLLIVWVSSFYRSNPIVQILEFTLAITIIGVFVLKTVEVDQAYKNKVAEFATDTYKTVCEAKTLG----LSI--KMLTGDAVGIARETSRQLGLGTNIYNAERLGLGGGPSLKKADTGIAVEGSSDAARSAAD-----IVFLAPGLGAIIDALKTSRQIFHRMYAYVVYRIALSIHLEIFLGLWIAILNRSLAYDNAPYSQTPVKWNLPKLWGMSVLLGVVLAVGTWITVTTMYAQGENGGIVQNFGLTENWLIFIT---------RANGPFWSSIPSWQLSGAIFLVDILATCFTIWGWFE

6a69A

0.11

0.09

3.35

0.74

FFAS-3D

----------------VVCVVLVTAFNDSKEKQFRGLQSRIEQDIAQVKYGDLLPADGILIQGNDLKIDESGES-DHVKKSLDKDPLLLSGTHVMEGSGRMVVTAVGVNSQTGIIFTLVLQGKLTKLAVQIGKAGLLMSAITVIILVLYFVIDTFWVQKRPWLAECTPIYKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKM----------------------------------------------MKDNNLVRHLDACETMGNATAICS-DKTGTLTMNRMTVVQAYINEKHYKKVPTSKILPPEKEGGLPRHVGNKTECALLGLLLDLKRDYQDVRNEIPYKVYTFNSVRKSMSTVLKYRIFSKGASEIILCFKILSANGEAKVFRPRDRDDIVKTVIEPMASEGLRTICLAFRDGLTCIVGIEDPEVPDAIKKCQRAGITVRMVTGD-

6a69A

0.10

0.09

3.30

0.83

SPARKS-K

GLSFYQPETGWIEGAAIVTAFNDWSKEKQFRGLQSRIEQEQKGDIAQVKYGDLLPADGILIQGND-------LKIDESSSDHVKKSLDKDPLLLSEGSGRMVVTAV--GVNSQTGIIFTLSVLQGKLTKLAVQIGKAGLLMSAITVIILVLYFVIDTFWVQKRPWLAE---------------CTPIYIQYFVKFFIIGVTVLVVAVPEGLP----------------------LAVTISLAYSVKKMM-KDNNLVRHLDACETMGNATA-ICSDKTGTLTMNRMTVVQAY---INEKHYKKVPPNILPEKEGGLPRHVGNKTECALLGLLLDLKRDYQDVR-------NEIPYKVYTFNSVRKSKYRILKKCFKILSANGEAKVFRPRDRDDIVKTVIEPMASEGLRTIC----LAFRDGLTCVVGIEDPEVPDAIKKCQRAGITVRMVTGDN

2zxeA

0.15

0.06

2.08

0.88

CNFpred

--------------------------------------------LVEVKGGDRIPADLRIISAH-GCKVDNPQTRSPEFSSENPLETRNIAF---EGTARGVVVYTTVMGRIATLASGLE-VGRTPIAIEIEHFIHIITGVAVFLGVSFFILSLIL---------GYSWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARK----------------------------------------------NCLVKNLEAVETLGSTSTICSDK-TGTLTQNRMTVAHMWFDN----------------------------------------------------------------------------------------------------------------------------------------------------------------

5xjcQ

0.08

0.05

1.90

0.67

DEthreader

ELICVAWEIFKFLDHCFNSL-V----------------------------------------------------------------------------------------------------------RREEDGHLFSQLLDMLKFYTGF-EINDQTGNAL----------LQFLTLHDYLLRNFNLFRLESTYEIRQDIEDSVSRMKPWFGGW-------------PYGTKFDRRPFIEQVGLVYVRVYTFNI-IMRR-KPKENNFKAVLTI-VPGLTM-----VTHSNLGSRRVYVLRIELLEVKRLQKSLGVP-------G--DASYTCETAGFFLQVMSRWEEYISVKN----------------------CFRHIKK--IFTQLEEFRASELLRSRSYL--EAKIIAMTCMEAAQ-LE--TFPLWIMIG----------LPPVIKNMFQ

2pffB

0.07

0.06

2.57

1.13

MapAlign

-EWLENPSNTPDKDYLLSIPISCPLIGVIQLAHYVVTAKLGVPSPMLSILPAGKQVEISLVNGAKNLVVSGPQSLAKAPSGLDQSRIPFSERKLKFSNRFLPFHSHLSDLINKDLVGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGG----------------------------------------GGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGG--GGGGGGGGGGGTQPALTLMEKAAFEDLKSKGLI

3ixzA

0.15

0.13

4.30

0.84

MUSTER

FGYQEFKSTNIIASFNLVPQQA-TVIRDGDKFQINADQLVVGD-LVEMKGGDRVPADIRILQAQGRKV-SPE---CTHESPLETRNIAFFSTMCLEGTAQGLVVNTGIIGRIASLASG-VENEKTPIAIEIEHFVDIIAGLAILFGATFFIV--------AMCIGYTFLRAMVFF-MAIVVAYVPEGLLATVTVCLSLTAKR----------------------------------------------LASKNCVVKNLEAVETLGSTSVICS-DKTGTLTQNRMTVSHLWF------DNHIHSADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIASETALLKFSELTLGNAMGYRERFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHVLVM-RVLERCSSILIKGQELPLDEQFQTAYLSLGGLGERVLGFCQLY

(a)	ID1 is the number of template residues identical to query divided by number of aligned residues.
(b)	ID2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment and is highlighted in bold.
(e)	Download alignment lists the threading program used to identify the template, and provide the 3D structure of aligned regions of threading templates (threading[1-10].pdb.gz).
(f)	Template residues identical to query sequence are highlighted in color.

Top 1 final models from D-I-TASSER

script 1 started

FileManager.getAtomSetCollectionFromFile(model1.pdb.gz)

FileManager opening 1 https://zhanglab.comp.nus.edu.sg/HPmod/data/Q12767/Q12767-D1/model1.pdb.gz

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The Resolver thinks Pdb

/jmol//j2s/core/corebio.z.js

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Time for openFile(model1.pdb.gz): 2939 ms

reading 6992 atoms

ModelSet: haveSymmetry:false haveUnitcells:false haveFractionalCoord:false

1 model in this collection. Use getProperty "modelInfo" or getProperty "auxiliaryInfo" to inspect them.

Default Van der Waals type for model set to Babel

6992 atoms created

ModelSet: autobonding; use autobond=false to not generate bonds automatically

Jmol 14.2.13_2015.03.07 2015-03-07 10:45 DSSP analysis for model 1.1 - null

W. Kabsch and C. Sander, Biopolymers, vol 22, 1983, pp 2577-2637

We thank Wolfgang Kabsch and Chris Sander for writing the DSSP software,

and we thank the CMBI for maintaining it to the extent that it was easy to

re-engineer for our purposes. At this point in time, we make no guarantee

that this code gives precisely the same analysis as the code available via license

from CMBI at http://swift.cmbi.ru.nl/gv/dssp

All bioshapes have been deleted and must be regenerated.

NOTE: Backbone amide hydrogen positions are present and will be ignored. Their positions will be approximated, as in standard DSSP analysis.

Use SET dsspCalculateHydrogenAlways FALSE to not use this approximation.

null

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SpinHigh qualityWhite background

Click to view	Rank^a	Download	Estimated TM-score^b
	1	model1.pdb.gz	0.5817

(a)

D-I-TASSER simulations generate a large ensemble of structural conformations, i.e. decoys. These decoys are clustered by SPICKER based on pairwise structure similarity to report up to five final models from the five largest clusters. Models are ranked in descending order of cluster size. If the simulations converge well, it is possible to have less than 5 models generated, which is usually an indication of good model quality.

(b)

The model confidence is quantitatified by estimated TM-score (eTM-score), calculated based on significance of threading template alignments, contact map satisfaction rate, mean absolute error between distance of model and distance of AttentionPotential, and convergence of D-I-TASSER simulations. eTM-score is typically in the range of [0, 1], with higher eTM-score signifies higher model confidence.

Proteins with similar structure

SpinHigh qualityWhite background

Top 10 structural analogs in PDB (as identified by TM-align)

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov.	Download Alignment
1	5xjcQ	0.38	6.87	0.033	0.604	model1_5xjcQ.pdb.gz
2	3v0aB	0.37	7.02	0.043	0.577	model1_3v0aB.pdb.gz
3	6cgrE	0.37	7.13	0.043	0.593	model1_6cgrE.pdb.gz
4	6rw8A	0.36	7.25	0.060	0.597	model1_6rw8A.pdb.gz
5	4zktB	0.36	7.13	0.032	0.568	model1_4zktB.pdb.gz
6	3vuoA	0.36	6.53	0.039	0.533	model1_3vuoA.pdb.gz
7	7kiyA	0.36	7.43	0.047	0.608	model1_7kiyA.pdb.gz
8	6r9tA	0.36	7.18	0.040	0.586	model1_6r9tA.pdb.gz
9	6w2dJ	0.35	7.09	0.051	0.584	model1_6w2dJ.pdb.gz
10	6ar6A	0.35	7.08	0.041	0.566	model1_6ar6A.pdb.gz

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov. represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted Gene Ontology (GO) Terms

Molecular Function (MF)

GO term	Cscore^GO	Name
GO:0008324	0.88	cation transmembrane transporter activity
GO:0019829	0.70	cation-transporting ATPase activity

Download full result of the above consensus prediction.

Click the graph to show a high resolution version.

(a)

Cscore^GO is the confidence score of predicted GO terms. Cscore^GO values range in between [0-1]; where a higher value indicates a better confidence in predicting the function using the template.

(b)

The graph shows the predicted terms within the Gene Ontology hierachy for Molecular Function. Confidently predicted terms are color coded by Cscore^GO:

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Biological Process (BP)

GO term	Cscore^GO	Name
GO:0006812	0.93	cation transport
GO:0009987	0.64	cellular process

Download full result of the above consensus prediction.

Click the graph to show a high resolution version.

(a)

Cscore^GO is the confidence score of predicted GO terms. Cscore^GO values range in between [0-1]; where a higher value indicates a better confidence in predicting the function using the template.

(b)

The graph shows the predicted terms within the Gene Ontology hierachy for Biological Process. Confidently predicted terms are color coded by Cscore^GO:

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Cellular Component (CC)

GO term	Cscore^GO	Name
GO:0005654	1.00	nucleoplasm

Download full result of the above consensus prediction.

Click the graph to show a high resolution version.

(a)

Cscore^GO is the confidence score of predicted GO terms. Cscore^GO values range in between [0-1]; where a higher value indicates a better confidence in predicting the function using the template.

(b)

The graph shows the predicted terms within the Gene Ontology hierachy for Cellular Component. Confidently predicted terms are color coded by Cscore^GO:

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted Enzyme Commission (EC) Numbers

SpinHigh qualityWhite background

Top 5 enzyme homologs in PDB

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov.	EC Number	Predicted Active Site Residues
1	0.060	3ixzA	0.323	5.96	0.053	0.469	3.6.3.10	275
2	0.060	3b8cA	0.313	7.14	0.040	0.511	3.6.3.6	NA
3	0.060	2vumA	0.318	7.39	0.032	0.540	2.7.7.6	NA
4	0.060	1dmrA	0.299	7.22	0.019	0.498	1.7.2.3	NA
5	0.060	3eqlD	0.302	8.05	0.050	0.551	2.7.7.6	NA

	Click on the radio buttons to visualize predicted active site residues.
(a)	Cscore^EC is the confidence score for the Enzyme Commission (EC) number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov. represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted Ligand Binding Sites

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Template proteins with similar binding site:

Rank	Cscore^LB	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov.	BS-score	Lig. Name	Download Complex	Predicted binding site residues
1	0.01	3ir5A	0.335	7.50	0.052	0.571	0.15	SF4	complex1.pdb.gz	54,55,57
2	0.01	3ir6A	0.214	7.71	0.029	0.368	0.11	GDP	complex2.pdb.gz	48,49,50,51,53
3	0.01	1g9aA	0.304	7.30	0.040	0.509	0.11	BAB	complex3.pdb.gz	47,50,51,52,53,54
4	0.01	2o01A	0.278	7.39	0.025	0.458	0.33	SF4	complex4.pdb.gz	49,52,75

	Click on the radio buttons to visualize predicted binding site and residues.
(a)	Cscore^LB is the confidence score of predicted binding site. Cscore^LB values range in between [0-1]; where a higher score indicates a more reliable ligand-binding site prediction.
(b)	BS-score is a measure of local similarity (sequence & structure) between template binding site and predicted binding site in the query structure. Based on large scale benchmarking analysis, we have observed that a BS-score >1 reflects a significant local match between the predicted and template binding site.
(c)	TM-score is a measure of global structural similarity between query and template protein.
(d)	RMSD^a the RMSD between residues that are structurally aligned by TM-align.
(e)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(f)	Cov. represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

[Click result.zip to download all results on this page]

References:
1.	Wei Zheng, Chengxin Zhang, Yang Li, Robin Pearce, Eric W. Bell, Yang Zhang. Folding non-homology proteins by coupling deep-learning contact maps with I-TASSER assembly simulations. In preparation, 2020.