D-I-TASSER results for P10645-D1

Input Sequence in FASTA format

>P10645 (457 residues)
MRSAAVLALLLCAGQVTALPVNSPMNKGDTEVMKCIVEVISDTLSKPSPMPVSQECFETL
RGDERILSILRHQNLLKELQDLALQGAKERAHQQKKHSGFEDELSEVLENQSSQAELKEA
VEEPSSKDVMEKREDSKEAEKSGEATDGARPQALPEPMQESKAEGNNQAPGEEEEEEEEA
TNTHPPASLPSQKYPGPQAEGDSEGLSQGLVDREKGLSAEPGWQAKREEEEEEEEEAEAG
EEAVPEEEGPTVVLNPHPSLGYKEIRKGESRSEALAVDGAGKPGAEEAQDPEGKGEQEHS
QQKEEEEEMAVVPQGLFRGGKSGELEQEEERLSKEWEDSKRWSKMDQLAKELTAEKRLEG
QEEEEDNRDSSMKLSFRARAYGFRGPGPQLRRGWRPSSREDSLEAGLPLQVRGYPEEKKE
EEGSANRRPEDQELESLSAIEAELEKVAHQLQALRRG

Predicted Secondary Structure

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Sequence
MRSAAVLALLLCAGQVTALPVNSPMNKGDTEVMKCIVEVISDTLSKPSPMPVSQECFETLRGDERILSILRHQNLLKELQDLALQGAKERAHQQKKHSGFEDELSEVLENQSSQAELKEAVEEPSSKDVMEKREDSKEAEKSGEATDGARPQALPEPMQESKAEGNNQAPGEEEEEEEEATNTHPPASLPSQKYPGPQAEGDSEGLSQGLVDREKGLSAEPGWQAKREEEEEEEEEAEAGEEAVPEEEGPTVVLNPHPSLGYKEIRKGESRSEALAVDGAGKPGAEEAQDPEGKGEQEHSQQKEEEEEMAVVPQGLFRGGKSGELEQEEERLSKEWEDSKRWSKMDQLAKELTAEKRLEGQEEEEDNRDSSMKLSFRARAYGFRGPGPQLRRGWRPSSREDSLEAGLPLQVRGYPEEKKEEEGSANRRPEDQELESLSAIEAELEKVAHQLQALRRG
Prediction
CCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHCCCHHHHHCCHHHCCCCCCCCCCCCCCCCHHHHCCCCCCCCHHHHHHHCCCCCCCCCCHHHCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHCCHHHHHHHHHCCCHHHCCCCCCCCCCCCCHHHHHHHCCCCHHHHCCCCCCCCCCCCCCCCCCCCHHHHCHHCCCHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCHHHCCCHHHHHCCCCCCCCHHHHHHHCHHHHCCCCCCCHHHHHCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
Confidence
9504899999999876313468866578612468999999764147888998978999873321356778777778888765420233221010024431122111110123210011101233310121111111221001121022110112221222201100112110000122100134432332122122111111100111022321011100011001111000011100110012010132112343322001111110010112101223442100012222221011001000112110243210113333331102222100034433244544443200101211012100123002101023420122345322332010102210111100123330330566655411223532122344777788899999888876339

H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

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Sequence
MRSAAVLALLLCAGQVTALPVNSPMNKGDTEVMKCIVEVISDTLSKPSPMPVSQECFETLRGDERILSILRHQNLLKELQDLALQGAKERAHQQKKHSGFEDELSEVLENQSSQAELKEAVEEPSSKDVMEKREDSKEAEKSGEATDGARPQALPEPMQESKAEGNNQAPGEEEEEEEEATNTHPPASLPSQKYPGPQAEGDSEGLSQGLVDREKGLSAEPGWQAKREEEEEEEEEAEAGEEAVPEEEGPTVVLNPHPSLGYKEIRKGESRSEALAVDGAGKPGAEEAQDPEGKGEQEHSQQKEEEEEMAVVPQGLFRGGKSGELEQEEERLSKEWEDSKRWSKMDQLAKELTAEKRLEGQEEEEDNRDSSMKLSFRARAYGFRGPGPQLRRGWRPSSREDSLEAGLPLQVRGYPEEKKEEEGSANRRPEDQELESLSAIEAELEKVAHQLQALRRG
Prediction
6300000000000010100104343545333012000200120034464342364024204666531531544623543553456545654655656554655446445556565556645655556556565665565665655565555555656655565556654665555665555655556646665555665565655565545555654555655656555656656556566555655555655555565565555655654655454655555555564567555565565645556546556654565555555555656456446536545545545654555554555665565555645455555546465555555555545655555556455545644555455565565654555365155145425533543453568

Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Contact, Hydrogen and Distance Map Used in D-I-TASSER simulation

D-I-TASSER simulation is guided by the consensus contact map (left figure), distance map (middle figure) and Hydrogen bond network (right figure) derived based on confidence scores of AttentionPotential. In the contact, distance map and hydrogen bond networks, the axes mark the residue index along the sequence. For the contact map, each dot represents a residue pair with predicted contact, while for the distance map and hydrogen bond network, a color scale represents a distance of 1-20+ angstroms or a angle of 0-180 degree.

Top 10 threading templates used by D-I-TASSER

Rank	PDB hit	ID1	ID2	Cov	Norm. Zscore	Download alignment		20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420                 440                    |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |
							SS	CCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHCCCHHHHHCCHHHCCCCCCCCCCCCCCCCHHHHCCCCCCCCHHHHHHHCCCCCCCCCCHHHCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHCCHHHHHHHHHCCCHHHCCCCCCCCCCCCCHHHHHHHCCCCHHHHCCCCCCCCCCCCCCCCCCCCHHHHCHHCCCHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCHHHCCCHHHHHCCCCCCCCHHHHHHHCHHHHCCCCCCCHHHHHCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
							Seq	MRSAAVLALLLCAGQVTALPVNSPMNKGDTEVMKCIVEVISDTLSKPSPMPVSQECFETLRGDERILSILRHQNLLKELQDLALQGAKERAHQQKKHSGFEDELSEVLENQSSQAELKEAVEEPSSKDVMEKREDSKEAEKSGEATDGARPQALPEPMQESKAEGNNQAPGEEEEEEEEATNTHPPASLPSQKYPGPQAEGDSEGLSQGLVDREKGLSAEPGWQAKREEEEEEEEEAEAGEEAVPEEEGPTVVLNPHPSLGYKEIRKGESRSEALAVDGAGKPGAEEAQDPEGKGEQEHSQQKEEEEEMAVVPQGLFRGGKSGELEQEEERLSKEWEDSKRWSKMDQLAKELTAEKRLEGQEEEEDNRDSSMKLSFRARAYGFRGPGPQLRRGWRPSSREDSLEAGLPLQVRGYPEEKKEEEGSANRRPEDQELESLSAIEAELEKVAHQLQALRRG
1	5yfpE	0.07	0.07	2.72	1.33	SPARKS-K		TDNFLGGLTVNEFVQELSKDHRNDVLIDANT-----------KNLPTNEKDQDAIREAIWKQLDPKPYIRTFESTLKELKNLNEETLNKRQYFSEQVATQEVIHSENVIKLSKDLHTTLLTFDKLDDRLTNVTQVVSPLGDKLETAIKKKQNIQSVELIRRYNDFYSMGKSDIVEQLRLSKNWK---LNLKSVKLILSSKLETSSIPKTINTKLVIEKYSEMMENELLENFN---------SAYRENNFTKAIILNNFNINQHDYFIFIKNVKFKEQ-LIDFENHSVIIETSMQNDVETVIKNESKIVKRVFEEKVFAQKIEPRFEVLLRNSLSIRILHGLFTLFGKFTKSLIDYFQLLEIDDSNQILSTTLEQCFADLFSHYLYDRSKMTSKFTVNYDKEINKRVLLDKYKEKLSTNTASDIDNSPNSPANYLNDVDSMLKCVVESTARVMELIPN
2	1vt4I3	0.08	0.08	3.24	1.00	MapAlign		-LHRSIVDHYNIPKTFDSDDLIPPYLDQYFYSHIGHHLKNIMTLFRMVFLDFRFLEQKILQQLKFYKPYICDNDPKYERLVNAILDFLPKIALMAEDEAIFEEAHKQVQGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGG--
3	3ecpA	0.07	0.07	2.91	0.52	CEthreader		-------TSALHRAADWAKSVFSSAALGDPRRTARLVNVAAQLAKYSG-KSITISSEGSKAAQEGAYRFIRNPNVSAEAIRKAGAMQTVKLAQEFPELLAIEDTTSLSYRHQVAEELGKLGSIQDKSRGWWVHSVLLLEATTFRTVGLLHQEWWMRPDDPADADEKESGKWLAAAATSRLRMGSMMSNVKLAHNERFVVRSKHPRKDVESGLYLYDHLKNQPELGGYQISIPQKGVVDKRGKRKNRPARKASLSLRSGRITLKQGNITLNAVLAEEINPPKGETPLKWLLLTSEPVESLAQALRVIDIYTHRWRIEEFHKAWKTGAGAERQRMEEPDNLERMVSILSFVAVRLLQLRESFTPSQSAETVLTPDECQLLGYLDKGKRKRKEKAG--------SLQWAYMAIARLGGFMDSKRTGIASWGALWEGWEALQSKLDGFLAAKDLMAQGIKI
4	5o9zG	0.08	0.08	3.16	0.75	EigenThreader		HPPAWIASARLEEVTLIMKGTEMCPKSEDVWLEAARAVVAQAVRHLPQSVRIYIRAAELETDIRAKKRVLRKALEHLWKAAEDARIMLSRAVECCPTSVELWLALARL----ETLNKARENIPTDRHIWITAAKLEEAN----GNTQMVEKIIDRAITSLRANGVEINREQWIQDAEECDRAGSVATCQAVMRAVIGIGIEEEDRKHTWMEDADSCVAHNALECARAIYAYALQVSVWLRAAYFEKNHGTRESLEALLQRAVAHCPKAEVLWLMGAKSKWLAGDALAFQANPNSEEIWLAAVKLESENERARRLLAKARSSAPTARVFMKSVKLEWVQRAAQDLCEEALRHYKLWMMKGQIEEQKEMMEKAREAYNQGLKKCPHSTPLWLLLSRLEEKIGQ----LTRARAILEKSRLKNPKNPGLWLESVRLEYNTLMAKALQEILWSEAIFLEAR
5	3jd8A3	0.07	0.07	2.83	0.68	FFAS-3D		--PLTLIVIEVIPFLVLAVGVDNIFRLQGETLDQQLGRVLGEVAPSMFLSSFSEHTFSLFAGLAVFIDFAEDGTSVQASESCLFRFFKNSYSPLLLKDWMRPIVIAIF----VGVLSFSIAVLNKVDIGLDQSLSMPDDSYMVDYFKSISQYLHAGPPVYFVLEEGHDYTSSKGQNMVCGGMGCNNDSLVQQIFNAAQLDNYTDDYFDWVKPQSSCCRVPEGKQRPQGGDFMRFLPMFLSDNPNPKCGKGGHAAYSSAVNILLGHGTRVGATYFMTYHTVLQTSADFID-----ALKKARLIASNVTETMGINGSAYRVFPYSVFYVFYEQYLTIIDDTIFNLGVSLGAIFLVT-------MVLLGCELWSAVIMCATIAMVLWGISLNAVSLVNLVMSCGSVEFCSHITRA-----FTVSMKGSRVERAEEALAHMSVFSGITLTKFGGIVVL---
6	7abiM	0.08	0.08	3.08	1.32	SPARKS-K		RALKLLPCSYKLWYRYLKARRAQVKHRCVTDPAYEDVNNCHERAFVFMHK-MPRLWLDYCQFLTHTRRTFDRARIWPLYLRFLRLPETAVRGYRRLSPESAEEYIEYLKSSDATVVNDERFVSKAGKSNYQLWHELCDLISQNPDKVQSLLTRFTDQLGKLWCSIRSGHFEKARDVYEEAIRTVMTVRDFTQDSYAQFEESMIAAKMETASELGREEEDDVDLELRLARFEQ-------LISRRPLLLNSVLLRQNPHHVHEWH-----KRVALHQGRPREIINTTEAVQTVDPFKATGKPHTLWVAFAKFYED-------NGQLDDARVILEKATKVNFKQVDDLASVWCQCGELELRHENYDEALRLLRKATALPARRAEYFDGSEPVQNRVYKSLKVWSMLADLEESLGTFQSTKAVYDRILDLRIATPQIINYAMFLEEFEESFKAYERGISL
7	2j68A	0.14	0.05	1.79	0.60	CNFpred		RAIAELRQVRTLARLACNHT---------REAVARRIPLLEQD---------VNELKKRIDSVEPEFNKLTRDEFQKEIINTRDTQARTISESFRS----VLNLGNTFENDFLRYQPELNLFDFLSSGKRE----------------------------------------------------AFNAALQKAFEQYITD--------------------------------------------------------------------------------------------------------------------------------------------KSAAWTLTAEKDINAAF--------------------------------------------------------------------------KELSRSASQYGASYNQITDQITEKLTG
8	6z2wE	0.08	0.06	2.35	0.67	DEthreader		-LLLKYRVNQLSPGFFQR--AG------NDFKLILNE-VILGRLACLESEKFSSTKPE-AGKSEIFRILHFGIFSLHRSSTRIIIAWTQLTLLLKLIDFNLVLLRQGQRYPNRQIFAYIYLPDLITNFEKDKRH----------------QEQAF-KKLQDNILFLIIYAPKKSIISAL--------K--GL-SESWDMNHKELY--AW-SSKTTIYLLSYLNHPLHVFFLLPYISLDII-LIIIEFDS-IFTCNLEGMNNLQV-------LRMCYEIFF-TT----L-----RSLETDSFSKNLQITYEISLDGVLRTFAT--------ELQYSE-WKKSMYDHQILEAVLQYNIAKALIASNEDPSMRKSFDQL------FLAARLDIA--S---------A-----YIYLEYPSHQNPH--SA-V-RPVV-SD---------S---IN--N---
9	3hizA	0.07	0.07	2.83	0.89	MapAlign		DCVPEQVIAEAIRKKVRTGIYHGGEPLCDNAARLCLSICSVKGRKGAKEPLAWGNINLFDYTDTLVSVVKFPDMSVIEEHANEQEKDFLWSHRHYCVTIPEILPKLLLSVKEVAQMYCLVKDWPPIKPEQAMELLDCNYPDPMVRGFAVRCLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTNQRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLWLNWENPDIMSELLFQNNEIIFKNGDDLTLQIIRIMENIWNSHTIMQIQCNSHTLHQWLKDKNKGEIYDAAIDLFTRSCAGYCVATFILGIGDRHNPFVLTQDFLIVISKGAQETKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIAYIRKTLALDKTEQEALEYFMKQMN
10	3tnfB	0.12	0.10	3.46	0.85	MUSTER		--------------------------------LDEYEQAIKRA----------QENIKKGEELEKKLDKLERQGKDLEDKYKTYEENLEGFEKLLTDSEELSEINEKMEAFSKDEKLTQLMEKHKGDEKTVQSLQREHHDIKAKLANLQVLHDAHTGKKSYVNEKGNPVSSLKDAHLAINKDQEV---VEHEGQFYLLQKGQWDAIKNNPAALEKAQKDYSQSKHDLATIKMEALIHKLSLEMEKQLETINNLIMSTDPKENEEATKLLHKHNGLNLKLANLQDMLAVHRKEEKGEEVTSLNDAHKDQQLFNLGGKFYPIHKEQKILEKDGKFYLLKQGEDWESIKDSPEKQKKAEHDFHKLQYET-----------------------------------------PMTVKKLVHHNKGLETTIHKERVEETKQQLEDNGKEKIEIANNISK----


(a) ID1 is the number of template residues identical to query divided by number of aligned residues.
(b) ID2 is the number of template residues identical to query divided by query sequence length.
(c) Cov is equal the number of aligned template residues divided by query sequence length.
(d) Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment and is highlighted in bold.
(e) Download alignment lists the threading program used to identify the template, and provide the 3D structure of aligned regions of threading templates (threading[1-10].pdb.gz).
(f) Template residues identical to query sequence are highlighted in color.

Top 1 final models from D-I-TASSER

Rank^a	Estimated TM-score^b
1	0.416


(a) D-I-TASSER simulations generate a large ensemble of structural conformations, i.e. decoys. These decoys are clustered by SPICKER based on pairwise structure similarity to report up to five final models from the five largest clusters. Models are ranked in descending order of cluster size. If the simulations converge well, it is possible to have less than 5 models generated, which is usually an indication of good model quality.
(b) The model confidence is quantitatified by estimated TM-score (eTM-score), calculated based on significance of threading template alignments, contact map satisfaction rate, mean absolute error between distance of model and distance of AttentionPotential, and convergence of D-I-TASSER simulations. eTM-score is typically in the range of [0, 1], with higher eTM-score signifies higher model confidence.

Proteins with similar structure

Top 10 structural analogs in PDB (as identified by TM-align)


Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov.
1	3qmzA	0.43	7.19	0.032	0.711
2	6z2wE	0.43	7.49	0.043	0.724
3	6vr4A	0.41	7.40	0.051	0.700
4	7dxjA	0.40	7.49	0.036	0.672
5	6g2dC	0.38	6.86	0.041	0.613
6	5i8iA	0.38	7.34	0.055	0.632
7	6sytA	0.37	7.58	0.041	0.654
8	5yz0A	0.37	6.91	0.052	0.597
9	6jxaA	0.37	7.83	0.032	0.652
10	4gfhA	0.37	7.60	0.069	0.637



(a) Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b) Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c) RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d) IDEN^a is the percentage sequence identity in the structurally aligned region.
(e) Cov. represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted Gene Ontology (GO) Terms

Molecular Function (MF)


GO term	Cscore^GO	Name
GO:1901363	0.57	heterocyclic compound binding
GO:0097159	0.57	organic cyclic compound binding
GO:0097367	0.52	carbohydrate derivative binding
GO:0000166	0.52	nucleotide binding
GO:0035639	0.51	purine ribonucleoside triphosphate binding
GO:0032555	0.51	purine ribonucleotide binding
GO:0032550	0.51	purine ribonucleoside binding
GO:0032559	0.50	adenyl ribonucleotide binding






(a) Cscore^GO is the confidence score of predicted GO terms. Cscore^GO values range in between [0-1]; where a higher value indicates a better confidence in predicting the function using the template.
(b) The graph shows the predicted terms within the Gene Ontology hierachy for Molecular Function. Confidently predicted terms are color coded by Cscore^GO:

Biological Process (BP)


GO term	Cscore^GO	Name
GO:0006887	1.00	exocytosis
GO:2000707	0.99	positive regulation of dense core granule biogenesis
GO:0050830	0.99	defense response to Gram-positive bacterium
GO:0050829	0.99	defense response to Gram-negative bacterium
GO:0043303	0.99	mast cell degranulation
GO:0033604	0.99	negative regulation of catecholamine secretion
GO:0032762	0.99	mast cell cytokine production
GO:0002551	0.99	mast cell chemotaxis
GO:0065008	0.69	regulation of biological quality
GO:0051239	0.68	regulation of multicellular organismal process
GO:0003008	0.68	system process
GO:0051241	0.67	negative regulation of multicellular organismal process
GO:0023051	0.67	regulation of signaling
GO:0010646	0.67	regulation of cell communication
GO:0080090	0.55	regulation of primary metabolic process
GO:0048522	0.55	positive regulation of cellular process
GO:0031323	0.55	regulation of cellular metabolic process
GO:0031325	0.53	positive regulation of cellular metabolic process
GO:0007165	0.53	signal transduction
GO:0019219	0.52	regulation of nucleobase-containing compound metabolic process
GO:0016043	0.52	cellular component organization
GO:0048583	0.51	regulation of response to stimulus
GO:0045935	0.51	positive regulation of nucleobase-containing compound metabolic process
GO:0019220	0.51	regulation of phosphate metabolic process
GO:0007186	0.51	G-protein coupled receptor signaling pathway
GO:0051240	0.50	positive regulation of multicellular organismal process
GO:0045937	0.50	positive regulation of phosphate metabolic process
GO:0009967	0.50	positive regulation of signal transduction
GO:0007187	0.50	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0006996	0.50	organelle organization






(a) Cscore^GO is the confidence score of predicted GO terms. Cscore^GO values range in between [0-1]; where a higher value indicates a better confidence in predicting the function using the template.
(b) The graph shows the predicted terms within the Gene Ontology hierachy for Biological Process. Confidently predicted terms are color coded by Cscore^GO:

Cellular Component (CC)


GO term	Cscore^GO	Name
GO:0044464	0.98	cell part
GO:0044424	0.97	intracellular part
GO:0044444	0.96	cytoplasmic part
GO:0043231	0.96	intracellular membrane-bounded organelle
GO:0030141	0.95	secretory granule
GO:0044421	0.72	extracellular region part
GO:0042583	0.70	chromaffin granule
GO:0005615	0.70	extracellular space
GO:0048471	0.50	perinuclear region of cytoplasm






(a) Cscore^GO is the confidence score of predicted GO terms. Cscore^GO values range in between [0-1]; where a higher value indicates a better confidence in predicting the function using the template.
(b) The graph shows the predicted terms within the Gene Ontology hierachy for Cellular Component. Confidently predicted terms are color coded by Cscore^GO:

Predicted Enzyme Commission (EC) Numbers

Top 5 enzyme homologs in PDB


Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov.	EC Number	Predicted Active Site Residues
1	0.060	1b0pA	0.241	7.62	0.031	0.420	1.2.7.1	NA
2	0.060	3hkzJ	0.276	7.49	0.039	0.457	2.7.7.6	NA
3	0.060	2uv8G	0.333	7.41	0.026	0.558	2.3.1.86	NA
4	0.060	2vz9B	0.320	8.03	0.061	0.580	2.3.1.85	NA
5	0.060	2qtcB	0.279	6.97	0.031	0.444	1.2.4.1	NA



(a) Cscore^EC is the confidence score for the Enzyme Commission (EC) number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b) TM-score is a measure of global structural similarity between query and template protein.
(c) RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d) IDEN^a is the percentage sequence identity in the structurally aligned region.
(e) Cov. represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted Ligand Binding Sites

Template proteins with similar binding site:

No Binding sites was predicted

References:
1. Wei Zheng, Chengxin Zhang, Yang Li, Robin Pearce, Eric W. Bell, Yang Zhang. Folding non-homology proteins by coupling deep-learning contact maps with I-TASSER assembly simulations. In preparation, 2020.